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- W4386837447 abstract "Anti-glomerular basement membrane (GBM) disease is a rare but life-threatening autoimmune disorder characterized by rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Renal biopsies of anti-GBM patients predominantly show linear deposition of IgG and complement component 3 (C3), indicating a close association between antigen-antibody reactions and subsequent complement activation in the pathogenesis of the disease. All three major pathways of complement activation, including the classical, lectin, and alternative pathways, are involved in human anti-GBM disease. Several complement factors, such as C3, C5b-9, and factor B, show a positive correlation with the severity of the renal injury and act as risk factors for renal outcomes. Furthermore, compared to patients with single positivity for anti-GBM antibodies, individuals who are double-seropositive for anti-neutrophil cytoplasmic antibody (ANCA) and anti-GBM antibodies exhibit a unique clinical phenotype that lies between ANCA-associated vasculitis (AAV) and anti-GBM disease. Complement activation may serve as a potential bridge for triggering both AAV and anti-GBM conditions. The aim of this article is to provide a comprehensive review of the latest clinical evidence regarding the role of complement activation in anti-GBM disease. Furthermore, potential therapeutic strategies targeting complement components and associated precautions are discussed, to establish a theoretical basis for complement-targeted therapies." @default.
- W4386837447 created "2023-09-19" @default.
- W4386837447 creator A5015186220 @default.
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- W4386837447 creator A5087684871 @default.
- W4386837447 date "2023-09-15" @default.
- W4386837447 modified "2023-10-05" @default.
- W4386837447 title "Unleashing the power of complement activation: unraveling renal damage in human anti-glomerular basement membrane disease" @default.
- W4386837447 cites W125031658 @default.
- W4386837447 cites W1748526476 @default.
- W4386837447 cites W1964890027 @default.
- W4386837447 cites W1967801774 @default.
- W4386837447 cites W1970345179 @default.
- W4386837447 cites W1973893419 @default.
- W4386837447 cites W1990281400 @default.
- W4386837447 cites W2005746644 @default.
- W4386837447 cites W2014403312 @default.
- W4386837447 cites W2019530336 @default.
- W4386837447 cites W2021140156 @default.
- W4386837447 cites W2021733158 @default.
- W4386837447 cites W2021959887 @default.
- W4386837447 cites W2023277595 @default.
- W4386837447 cites W2038889007 @default.
- W4386837447 cites W2039674319 @default.
- W4386837447 cites W2041326076 @default.
- W4386837447 cites W2043859733 @default.
- W4386837447 cites W2046950665 @default.
- W4386837447 cites W2047080292 @default.
- W4386837447 cites W2056041744 @default.
- W4386837447 cites W2060987046 @default.
- W4386837447 cites W2065400099 @default.
- W4386837447 cites W2081308292 @default.
- W4386837447 cites W2085892570 @default.
- W4386837447 cites W2090772115 @default.
- W4386837447 cites W2099244772 @default.
- W4386837447 cites W2105732749 @default.
- W4386837447 cites W2106047038 @default.
- W4386837447 cites W2109310276 @default.
- W4386837447 cites W2116367050 @default.
- W4386837447 cites W2122321307 @default.
- W4386837447 cites W2133890245 @default.
- W4386837447 cites W2137701578 @default.
- W4386837447 cites W2138046831 @default.
- W4386837447 cites W2140297546 @default.
- W4386837447 cites W2142060864 @default.
- W4386837447 cites W2142805987 @default.
- W4386837447 cites W2143255095 @default.
- W4386837447 cites W2155682255 @default.
- W4386837447 cites W2156303340 @default.
- W4386837447 cites W2157745361 @default.
- W4386837447 cites W2158595140 @default.
- W4386837447 cites W2164703730 @default.
- W4386837447 cites W2165083304 @default.
- W4386837447 cites W2304984140 @default.
- W4386837447 cites W2397512299 @default.
- W4386837447 cites W2407051589 @default.
- W4386837447 cites W2428836550 @default.
- W4386837447 cites W2467831176 @default.
- W4386837447 cites W2472545716 @default.
- W4386837447 cites W2513418653 @default.
- W4386837447 cites W2541821639 @default.
- W4386837447 cites W2542867039 @default.
- W4386837447 cites W2587049291 @default.
- W4386837447 cites W2590412695 @default.
- W4386837447 cites W2603618866 @default.
- W4386837447 cites W2613744835 @default.
- W4386837447 cites W2614646425 @default.
- W4386837447 cites W2705109811 @default.
- W4386837447 cites W2736872201 @default.
- W4386837447 cites W2769849869 @default.
- W4386837447 cites W2775288206 @default.
- W4386837447 cites W2789927285 @default.
- W4386837447 cites W2888692684 @default.
- W4386837447 cites W2901128710 @default.
- W4386837447 cites W2901284057 @default.
- W4386837447 cites W2912032993 @default.
- W4386837447 cites W2914604561 @default.
- W4386837447 cites W2937567764 @default.
- W4386837447 cites W2952273776 @default.
- W4386837447 cites W2964012416 @default.
- W4386837447 cites W2972127807 @default.
- W4386837447 cites W3010216446 @default.
- W4386837447 cites W3083666150 @default.
- W4386837447 cites W3106878201 @default.
- W4386837447 cites W3111539722 @default.
- W4386837447 cites W3120936814 @default.
- W4386837447 cites W3126344636 @default.
- W4386837447 cites W3126921515 @default.
- W4386837447 cites W3127629321 @default.
- W4386837447 cites W3131777419 @default.
- W4386837447 cites W3139465119 @default.
- W4386837447 cites W3148748347 @default.
- W4386837447 cites W3168935157 @default.
- W4386837447 cites W3178506823 @default.
- W4386837447 cites W3200553460 @default.
- W4386837447 cites W3203644875 @default.