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• W4386840876 endingPage "102810" @default.
• W4386840876 startingPage "102810" @default.
• W4386840876 abstract "Trichinosis spiralis is a global disease with significant economic impact. Albendazole is the current-treatment. Yet, the world-widely emerging antimicrobial resistance necessitates search for therapeutic substitutes. Curcumin is a natural compound with abundant therapeutic benefits. This study aimed to evaluate the potential of crude-curcumin, chitosan and for the first time curcumin-nano-emulsion and curcumin-loaded-chitosan-nanoparticles against Trichinella spiralis adults and larvae in acute and chronic trichinosis models. Trichinosis spiralis was induced in 96 Swiss-albino mice. Infected mice were divided into 2 groups. Group I constituted the acute model, where treatment started 2 h after infection for 5 successive days. Group II constituted the chronic model, where treatment started at the 30th day-post-infection and continued for 10 successive days (Refer to graphical abstract). Each group contained 8 subgroups that were designated Ia-Ih and IIa-IIh and included; a; Untreated-control, b; Albendazole-treated (Alb-treated), c; Crude-curcumin-treated (Cur-treated), d; Curcumin-nanoemulsion-treated (Cur-NE-treated), e; Albendazole and crude-curcumin-treated (Alb-Cur-treated), f; Albendazole and curcumin-nanoemulsion-treated (Alb-Cur-NE-treated), g; Chitosan-nanoparticles-treated (CS-NPs-treated) and h; Curcumin-loaded-chitosan-nanoparticles-treated (Cur-CS-NPs-treated). Additionally, six mice constituted control-uninfected group III. The effects of the used compounds on the parasite tegument, in-vivo parasitic load-worm burden, local pathology and MDA concentration in small intestines of acutely-infected and skeletal muscle of chronically-infected mice were studied. Results showed that albendazole was effective, yet, its combination with Cur-NE showed significant potentiation against adult worms and muscle larvae and alleviated the pathology in both models. Cur-CS-NPs exhibited promising results in both models. Crude-curcumin showed encouraging results especially against muscle larvae on long-term use. Treatments effectively reduced parasite load, local MDA level and CD31 expression with anti-inflammatory effect in intestine and muscle sections." @default.
• W4386840876 created "2023-09-19" @default.
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• W4386840876 date "2024-02-01" @default.
• W4386840876 modified "2023-09-30" @default.
• W4386840876 title "Trichinella spiralis: A new parasitic target for curcumin nanoformulas in mice models" @default.
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• W4386840876 cites W1972751633 @default.
• W4386840876 cites W1979920999 @default.
• W4386840876 cites W1981965679 @default.
• W4386840876 cites W1983310681 @default.
• W4386840876 cites W1986913983 @default.
• W4386840876 cites W1987300778 @default.
• W4386840876 cites W1987551832 @default.
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• W4386840876 cites W1993915524 @default.
• W4386840876 cites W1997108743 @default.
• W4386840876 cites W2000438184 @default.
• W4386840876 cites W2002293448 @default.
• W4386840876 cites W2011337131 @default.
• W4386840876 cites W2019524924 @default.
• W4386840876 cites W2019949517 @default.
• W4386840876 cites W2022467626 @default.
• W4386840876 cites W2025305236 @default.
• W4386840876 cites W2037222034 @default.
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• W4386840876 cites W2059363683 @default.
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• W4386840876 cites W2105715022 @default.
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• W4386840876 cites W2126823935 @default.
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• W4386840876 cites W2213103346 @default.
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• W4386840876 cites W2554209253 @default.
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• W4386840876 cites W2564113516 @default.
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• W4386840876 cites W2753802610 @default.
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• W4386840876 cites W2792969494 @default.
• W4386840876 cites W2803673699 @default.
• W4386840876 cites W2885611979 @default.
• W4386840876 cites W2899979523 @default.
• W4386840876 cites W2914423772 @default.
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• W4386840876 doi "https://doi.org/10.1016/j.parint.2023.102810" @default.
• W4386840876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37730195" @default.
• W4386840876 hasPublicationYear "2024" @default.
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