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- W4386840907 abstract "Optimal dietary intake of omega-3 long-chain polyunsaturated fatty acids (n3-LCPUFA) is critical to human health across the lifespan. However, omega-3 index (O3I) determination is not routinely assessed due to complicated procedures for n3-LCPUFA analysis from the phospholipid (PL) fraction of erythrocytes. Herein, a high-throughput method for lipidomics based on multisegment injection-nonaqueous capillary electrophoresis-mass spectrometry was applied to identify circulating PLs as surrogate biomarkers of O3I in two randomized placebo-controlled trials. An untargeted lipidomic data workflow using a sub-group analysis of serum extracts from sunflower oil versus high-dose fish oil (FO) supplemented participants revealed that ingested n3-LCPUFAs were primarily distributed as their phosphatidylcholines (PCs) relative to other PL classes. In both high-dose FO (5.0 g/day), and eicosapentaenoic acid (EPA) only trials (3.0 g/day), PC (16:0_20:5) was the most responsive PL, whereas PC (16:0_22:6) was selective to docosahexaenoic acid (DHA) only supplementation. We also demonstrated that the sum concentration of both these PCs in fasting serum or plasma samples was positively correlated to the O3I following FO (r = 0.708, p = 1.02 × 10-11, n=69), and EPA or DHA only supplementation (r = 0.768, p = 1.01 × 10-33, n=167). Overall, DHA was more effective in improving the O3I (ΔO3I = 4.90 ± 1.33%) compared to EPA (ΔO3I = 2.99 ± 1.19%) in young Canadian adults who had a poor nutritional status with a O3I (3.50 ± 0.68%) at baseline. Our method enables the rapid assessment of the O3I by directly measuring two circulating PC species in small volumes of blood." @default.
- W4386840907 created "2023-09-19" @default.
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- W4386840907 date "2023-09-01" @default.
- W4386840907 modified "2023-09-27" @default.
- W4386840907 title "Lipidomic Studies Reveal Specific Circulating Phosphatidylcholines as Surrogate Biomarkers of Omega-3 Index" @default.
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- W4386840907 doi "https://doi.org/10.1016/j.jlr.2023.100445" @default.
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