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- W4386844892 abstract "The γG-158 (C-T) polymorphism plays important function in the disease severity of sickle cell anemia.The XmnI restriction site at -158 position of the γG-gene is associated with increased expression of the γG-globin gene and higher production of HbF. This study aims to determine the frequency of the different genotypes of the γG Xmn I polymorphism in sickle cell anemia and sickle cell trait patients in Chhattisgarh and its association with high HbFlevel. The Xmn1 polymorphic site was determined by PCR-RFLP procedure. XmnI polymorphism were studied in 100 sickle cell patients (SS), 50 sickle cell trait(AS) and 50 controls individuals (AA). The presence of XmnI (+/+) site in SS and AS patients associated with the increase of HbF (P<0.0001) synthesis. we also find that presence of one XmnI (+/-) site in SS patients compared with XmnI-/- site had not shows difference in HbF level.Polymorphic association is foundbetween presence and absence of XmnI site with HbF level, in AS and AA individuals." @default.
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- W4386844892 date "2012-03-15" @default.
- W4386844892 modified "2023-10-11" @default.
- W4386844892 title "Association between XmnI Polymorphism and HbF Level in Sickle Cell Disease Patients from Chhattisgarh" @default.
- W4386844892 doi "https://doi.org/10.59566/ijbs.2012.8036" @default.
- W4386844892 hasPublicationYear "2012" @default.
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