FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386845260> ?p ?o ?g. }

• W4386845260 abstract "Development of validated biomarkers to detect early Alzheimer disease (AD) neuropathology is needed for therapeutic AD trials. Abnormal concentrations of core AD biomarkers, cerebrospinal fluid (CSF) amyloid beta1-42, total tau, and phosphorylated tau correlate well with neuroimaging biomarkers and autopsy findings. Nevertheless, given the limitations of established CSF and neuroimaging biomarkers, accelerated development of blood-based AD biomarkers is underway.Here we describe the clinical significance of CSF and plasma AD biomarkers to detect disease pathology throughout the Alzheimer continuum and correlate with imaging biomarkers. Use of the AT(N) classification by CSF and imaging biomarkers provides a more objective biologically based diagnosis of AD than clinical diagnosis alone. Significant progress in measuring CSF AD biomarkers using extensively validated highly automated assay systems has facilitated their transition from research use only to approved in vitro diagnostics tests for clinical use. We summarize development of plasma AD biomarkers as screening tools for enrollment and monitoring participants in therapeutic trials and ultimately in clinical care. Finally, we discuss the challenges for AD biomarkers use in clinical trials and precision medicine, emphasizing the possible ethnocultural differences in the levels of AD biomarkers.CSF AD biomarker measurements using fully automated analytical platforms is possible. Building on this experience, validated blood-based biomarker tests are being implemented on highly automated immunoassay and mass spectrometry platforms. The progress made developing analytically and clinically validated plasma AD biomarkers within the AT(N) classification scheme can accelerate use of AD biomarkers in therapeutic trials and routine clinical practice." @default.
• W4386845260 created "2023-09-20" @default.
• W4386845260 creator A5006541290 @default.
• W4386845260 creator A5023136222 @default.
• W4386845260 creator A5027124985 @default.
• W4386845260 creator A5028577106 @default.
• W4386845260 creator A5029739306 @default.
• W4386845260 creator A5041387594 @default.
• W4386845260 creator A5044127793 @default.
• W4386845260 creator A5047764067 @default.
• W4386845260 creator A5061968243 @default.
• W4386845260 creator A5076949942 @default.
• W4386845260 creator A5081337965 @default.
• W4386845260 date "2023-09-19" @default.
• W4386845260 modified "2023-09-27" @default.
• W4386845260 title "Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology" @default.
• W4386845260 cites W1031095229 @default.
• W4386845260 cites W1208364757 @default.
• W4386845260 cites W1870043354 @default.
• W4386845260 cites W1964472291 @default.
• W4386845260 cites W1974300727 @default.
• W4386845260 cites W1986400971 @default.
• W4386845260 cites W1992165389 @default.
• W4386845260 cites W2007044705 @default.
• W4386845260 cites W2008301592 @default.
• W4386845260 cites W2041004450 @default.
• W4386845260 cites W2046059051 @default.
• W4386845260 cites W2060446879 @default.
• W4386845260 cites W2065338300 @default.
• W4386845260 cites W2103861278 @default.
• W4386845260 cites W2106156541 @default.
• W4386845260 cites W2111951761 @default.
• W4386845260 cites W2130983640 @default.
• W4386845260 cites W2144647267 @default.
• W4386845260 cites W2151384687 @default.
• W4386845260 cites W2161737267 @default.
• W4386845260 cites W2167840686 @default.
• W4386845260 cites W2173601762 @default.
• W4386845260 cites W2266863819 @default.
• W4386845260 cites W2397701197 @default.
• W4386845260 cites W2410020047 @default.
• W4386845260 cites W2414917913 @default.
• W4386845260 cites W2473313434 @default.
• W4386845260 cites W2511591175 @default.
• W4386845260 cites W2525940741 @default.
• W4386845260 cites W2600914407 @default.
• W4386845260 cites W267135921 @default.
• W4386845260 cites W2727929522 @default.
• W4386845260 cites W2736031396 @default.
• W4386845260 cites W2736518852 @default.
• W4386845260 cites W2767595531 @default.
• W4386845260 cites W2785757836 @default.
• W4386845260 cites W2789976306 @default.
• W4386845260 cites W2794074331 @default.
• W4386845260 cites W2794653302 @default.
• W4386845260 cites W2798054687 @default.
• W4386845260 cites W2811128719 @default.
• W4386845260 cites W2883286350 @default.
• W4386845260 cites W2884982789 @default.
• W4386845260 cites W2890854685 @default.
• W4386845260 cites W2900969253 @default.
• W4386845260 cites W2903592416 @default.
• W4386845260 cites W2906702113 @default.
• W4386845260 cites W2910313823 @default.
• W4386845260 cites W2912031262 @default.
• W4386845260 cites W2938221890 @default.
• W4386845260 cites W2966365568 @default.
• W4386845260 cites W2990953582 @default.
• W4386845260 cites W2996205525 @default.
• W4386845260 cites W3011286447 @default.
• W4386845260 cites W3014879687 @default.
• W4386845260 cites W3045987239 @default.
• W4386845260 cites W3047014868 @default.
• W4386845260 cites W3093943691 @default.
• W4386845260 cites W3106880531 @default.
• W4386845260 cites W3111672229 @default.
• W4386845260 cites W3112532374 @default.
• W4386845260 cites W3133740925 @default.
• W4386845260 cites W3135276443 @default.
• W4386845260 cites W3137826907 @default.
• W4386845260 cites W3158280019 @default.
• W4386845260 cites W3174265554 @default.
• W4386845260 cites W3182927843 @default.
• W4386845260 cites W3214993261 @default.
• W4386845260 cites W4200312217 @default.
• W4386845260 cites W4200531219 @default.
• W4386845260 cites W4220941214 @default.
• W4386845260 cites W4224321671 @default.
• W4386845260 cites W4280490458 @default.
• W4386845260 cites W4281564421 @default.
• W4386845260 cites W4283717411 @default.
• W4386845260 cites W4292791024 @default.
• W4386845260 cites W4295107480 @default.
• W4386845260 cites W4302306887 @default.
• W4386845260 cites W4303859604 @default.
• W4386845260 cites W4308890634 @default.
• W4386845260 cites W4310461604 @default.
• W4386845260 doi "https://doi.org/10.1093/clinchem/hvad139" @default.
• W4386845260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37725909" @default.
• W4386845260 hasPublicationYear "2023" @default.

• next