Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386845361> ?p ?o ?g. }
- W4386845361 abstract "Functions of protein SUMOylation remain incompletely understood in different cell types. Via forward genetics, here we identified ubaBQ247*, a loss-of-function mutation in a SUMO-activation enzyme UbaB in the filamentous fugus Aspergillus nidulans. The ubaBQ247*, ΔubaB and ΔsumO mutants all produce abnormal chromatin bridges, indicating the importance of SUMOylation in the completion of chromosome segregation. The bridges are enclosed by nuclear membrane containing peripheral nuclear-pore-complex proteins that normally get dispersed during mitosis, and the bridges are also surrounded by cytoplasmic microtubules typical of interphase cells. Time-lapse sequences further indicate that most bridges persist through interphase prior to the next mitosis, and anaphase chromosome segregation can produce new bridges that persist into the next interphase. When the first mitosis happens at a higher temperature of 42°C, SUMOylation deficiency produces not only chromatin bridges but also many abnormally shaped single nuclei that fail to divide. UbaB-GFP localizes to interphase nuclei just like the previously studied SumO-GFP, but the nuclear signals disappear during mitosis when the nuclear pores are partially open, and the signals reappear after mitosis. The nuclear localization is consistent with many SUMO-targets being nuclear proteins. Finally, although the budding yeast SUMOylation machinery interacts with LIS1, a protein critical for dynein activation, loss of SUMOylation does not cause any obvious defect in dynein-mediated transport of nuclei and early endosomes, indicating that SUMOylation is unnecessary for dynein activation in A. nidulans." @default.
- W4386845361 created "2023-09-20" @default.
- W4386845361 creator A5004179698 @default.
- W4386845361 creator A5047268930 @default.
- W4386845361 creator A5071672663 @default.
- W4386845361 creator A5079938686 @default.
- W4386845361 creator A5080382205 @default.
- W4386845361 creator A5085016805 @default.
- W4386845361 creator A5086853276 @default.
- W4386845361 date "2023-09-19" @default.
- W4386845361 modified "2023-10-15" @default.
- W4386845361 title "Aspergillus SUMOylation mutants exhibit chromosome-segregation defects including chromatin bridges" @default.
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