FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386849568> ?p ?o ?g. }

• W4386849568 endingPage "20" @default.
• W4386849568 startingPage "8" @default.
• W4386849568 abstract "Purpose. To study the efficacy and safety of total neoadjuvant chemotherapy (NACT) with the FOLFIRINOX regimen for locally advanced gastric (GC) and cardioesophageal junction (CEJ) cancer. Patients and methods . Patients with histologically confirmed locally advanced gastric adenocarcinoma and CEJ, clinical stage cT3 or higher and/or regional lymph node involvement (cN+), without evidence of distant metastasis were included in our open-label, single-centre, non-randomised study. In the FLOT control group, patients received 4 courses preoperatively and 4 postoperatively with follow-up. I In the FOLFIRINOX group 8 courses of chemotherapy were administered in neoadjuvant mode, followed by surgery and observation. The tumor regression grade was assessed in accordance with Becker, Mandard and G. A. Lavnikova scales. Results. The study included 136 patients, 119 of whom started treatment according to the protocol (ITT population). Fiſty-nine patients were enrolled into the FLOT group and 60 into the FOLFIRINOX group. One-year progression-free survival (PFS) was 67,5 % in the FLOT group and 90,4 % in the FOLFIRINOX group (p = 0,29). The estimated 2-year PFS in the FLOT group was 61,4 % [95 % CI, 48,4–77,9 %]. Median PFS and overall survival (OS) were not reached. The incidence of events (progression or death) was lower in the FOLFIRINOX group (odds ratio [OR] 0,40 [95 % CI 0,16–0,97, p = 0,047]). Adverse prognostic factors regardless of treatment were lymphatic (L1), vascular (V1) and perineural invasion (Pn1), and regional lymph node involvement aſter chemotherapy (ypN+) [p = 0,046; p = 0,014; p = 0,0021; p = 0,04, respectively]. There was no correlation between pathological complete response and survival rates. Conclusion . Total neoadjuvant chemotherapy with the FOLFIRINOX regimen for locally advanced GC/ CEJ demonstrated comparable to the perioperative FLOT one-year PFS rate. No association was found between tumor regression grade and survival outcomes." @default.
• W4386849568 created "2023-09-20" @default.
• W4386849568 creator A5027172893 @default.
• W4386849568 creator A5052911447 @default.
• W4386849568 creator A5057444889 @default.
• W4386849568 creator A5059852112 @default.
• W4386849568 creator A5059965880 @default.
• W4386849568 creator A5072427891 @default.
• W4386849568 date "2023-08-23" @default.
• W4386849568 modified "2023-09-27" @default.
• W4386849568 title "Total neoadjuvant chemotherapy according to the FOLFIRINOX regimen for locally advanced adenocarcinoma of the stomach and cardioesophageal junction: interim results" @default.
• W4386849568 cites W1921454671 @default.
• W4386849568 cites W1988439088 @default.
• W4386849568 cites W1999815205 @default.
• W4386849568 cites W2030430663 @default.
• W4386849568 cites W2058070181 @default.
• W4386849568 cites W2071272359 @default.
• W4386849568 cites W2113947048 @default.
• W4386849568 cites W2115072149 @default.
• W4386849568 cites W2146834306 @default.
• W4386849568 cites W2157127974 @default.
• W4386849568 cites W2537321298 @default.
• W4386849568 cites W2610524145 @default.
• W4386849568 cites W2898137004 @default.
• W4386849568 cites W2938774982 @default.
• W4386849568 cites W2946036719 @default.
• W4386849568 cites W2980050728 @default.
• W4386849568 cites W2998629541 @default.
• W4386849568 cites W3029901399 @default.
• W4386849568 cites W3134169204 @default.
• W4386849568 cites W4211130279 @default.
• W4386849568 cites W4214855277 @default.
• W4386849568 cites W4321788579 @default.
• W4386849568 doi "https://doi.org/10.17709//2410-1893-2023-10-3-1" @default.
• W4386849568 hasPublicationYear "2023" @default.
• W4386849568 type Work @default.
• W4386849568 citedByCount "0" @default.
• W4386849568 crossrefType "journal-article" @default.
• W4386849568 hasAuthorship W4386849568A5027172893 @default.
• W4386849568 hasAuthorship W4386849568A5052911447 @default.
• W4386849568 hasAuthorship W4386849568A5057444889 @default.
• W4386849568 hasAuthorship W4386849568A5059852112 @default.
• W4386849568 hasAuthorship W4386849568A5059965880 @default.
• W4386849568 hasAuthorship W4386849568A5072427891 @default.
• W4386849568 hasBestOaLocation W43868495681 @default.
• W4386849568 hasConcept C121608353 @default.
• W4386849568 hasConcept C126322002 @default.
• W4386849568 hasConcept C141071460 @default.
• W4386849568 hasConcept C143998085 @default.
• W4386849568 hasConcept C2776694085 @default.
• W4386849568 hasConcept C2777148230 @default.
• W4386849568 hasConcept C2778292576 @default.
• W4386849568 hasConcept C2780962732 @default.
• W4386849568 hasConcept C2781413609 @default.
• W4386849568 hasConcept C2908647359 @default.
• W4386849568 hasConcept C526805850 @default.
• W4386849568 hasConcept C530470458 @default.
• W4386849568 hasConcept C71924100 @default.
• W4386849568 hasConcept C99454951 @default.
• W4386849568 hasConceptScore W4386849568C121608353 @default.
• W4386849568 hasConceptScore W4386849568C126322002 @default.
• W4386849568 hasConceptScore W4386849568C141071460 @default.
• W4386849568 hasConceptScore W4386849568C143998085 @default.
• W4386849568 hasConceptScore W4386849568C2776694085 @default.
• W4386849568 hasConceptScore W4386849568C2777148230 @default.
• W4386849568 hasConceptScore W4386849568C2778292576 @default.
• W4386849568 hasConceptScore W4386849568C2780962732 @default.
• W4386849568 hasConceptScore W4386849568C2781413609 @default.
• W4386849568 hasConceptScore W4386849568C2908647359 @default.
• W4386849568 hasConceptScore W4386849568C526805850 @default.
• W4386849568 hasConceptScore W4386849568C530470458 @default.
• W4386849568 hasConceptScore W4386849568C71924100 @default.
• W4386849568 hasConceptScore W4386849568C99454951 @default.
• W4386849568 hasIssue "3" @default.
• W4386849568 hasLocation W43868495681 @default.
• W4386849568 hasOpenAccess W4386849568 @default.
• W4386849568 hasPrimaryLocation W43868495681 @default.
• W4386849568 hasRelatedWork W1985988050 @default.
• W4386849568 hasRelatedWork W2206740068 @default.
• W4386849568 hasRelatedWork W2799331799 @default.
• W4386849568 hasRelatedWork W2910998150 @default.
• W4386849568 hasRelatedWork W3030047436 @default.
• W4386849568 hasRelatedWork W3041068603 @default.
• W4386849568 hasRelatedWork W3159642080 @default.
• W4386849568 hasRelatedWork W4226078215 @default.
• W4386849568 hasRelatedWork W4380150473 @default.
• W4386849568 hasRelatedWork W757206253 @default.
• W4386849568 hasVolume "10" @default.
• W4386849568 isParatext "false" @default.
• W4386849568 isRetracted "false" @default.
• W4386849568 workType "article" @default.