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- W4386850660 abstract "This research focused on the identification of herbal compounds as potential anti-cancer drugs, especially for breast cancer, that involved the recognition of Notch downstream targets NOTCH proteins (1-4) specifically expressed in breast tumours as biomarkers for prognosis, along with P53 tumour antigens, that were used as comparisons to check the sensitivity of the herbal bio-compounds.After investigating phytochemical candidates, we employed an approach for computer-aided drug design and analysis to find strong breast cancer inhibitors. The present study utilized in silico analyses and protein docking techniques to characterize and rank selected bio-compounds for their efficiency in oncogenic inhibition for use in precise carcinomic cell growth control.Several of the identified phytocompounds found in herbs followed Lipinski's Rule of Five and could be further investigated as potential medicinal molecules. Based on the Vina score obtained after the docking process, the active compound Epigallocatechin gallate in green tea with NOTCH (1-4) and P53 proteins showed promising results for future drug repurposing. The stiffness and binding stability of green tea pharmacological complexes were further elucidated by the molecular dynamic simulations carried out for the highest scoring phytochemical ligand complex.The target-ligand complex of green tea active compound Epigallocatechin gallate with NOTCH (1-4) had the potential to become potent anti-breast cancer therapeutic candidates following further research involving wet-lab experiments." @default.
- W4386850660 created "2023-09-20" @default.
- W4386850660 creator A5028726869 @default.
- W4386850660 creator A5064595614 @default.
- W4386850660 creator A5086512872 @default.
- W4386850660 date "2023-09-20" @default.
- W4386850660 modified "2023-09-27" @default.
- W4386850660 title "Analysing potent biomarkers along phytochemicals for breast cancer therapy: an in silico approach" @default.
- W4386850660 cites W1485232676 @default.
- W4386850660 cites W1969335165 @default.
- W4386850660 cites W1983876698 @default.
- W4386850660 cites W1997801717 @default.
- W4386850660 cites W2008489675 @default.
- W4386850660 cites W2010460880 @default.
- W4386850660 cites W2029470195 @default.
- W4386850660 cites W2047074552 @default.
- W4386850660 cites W2054244815 @default.
- W4386850660 cites W2061996746 @default.
- W4386850660 cites W2067266295 @default.
- W4386850660 cites W2073915362 @default.
- W4386850660 cites W2087386747 @default.
- W4386850660 cites W2089153118 @default.
- W4386850660 cites W2094169904 @default.
- W4386850660 cites W2102078552 @default.
- W4386850660 cites W2102428199 @default.
- W4386850660 cites W2103267380 @default.
- W4386850660 cites W2109401430 @default.
- W4386850660 cites W2112411768 @default.
- W4386850660 cites W2113342764 @default.
- W4386850660 cites W2122665497 @default.
- W4386850660 cites W2133943800 @default.
- W4386850660 cites W2134967712 @default.
- W4386850660 cites W2142279282 @default.
- W4386850660 cites W2147598859 @default.
- W4386850660 cites W2147842136 @default.
- W4386850660 cites W2152630148 @default.
- W4386850660 cites W2152725741 @default.
- W4386850660 cites W2153781246 @default.
- W4386850660 cites W2153936226 @default.
- W4386850660 cites W2156235307 @default.
- W4386850660 cites W2166150927 @default.
- W4386850660 cites W2171462836 @default.
- W4386850660 cites W2193806089 @default.
- W4386850660 cites W2326077896 @default.
- W4386850660 cites W2343614482 @default.
- W4386850660 cites W2417516190 @default.
- W4386850660 cites W2419558864 @default.
- W4386850660 cites W2508173956 @default.
- W4386850660 cites W2520938304 @default.
- W4386850660 cites W2547330766 @default.
- W4386850660 cites W2612650514 @default.
- W4386850660 cites W2744829308 @default.
- W4386850660 cites W2791370644 @default.
- W4386850660 cites W2792290541 @default.
- W4386850660 cites W2792951836 @default.
- W4386850660 cites W2794491987 @default.
- W4386850660 cites W2796127234 @default.
- W4386850660 cites W2888628722 @default.
- W4386850660 cites W2892210443 @default.
- W4386850660 cites W2901399105 @default.
- W4386850660 cites W2902225381 @default.
- W4386850660 cites W2903318135 @default.
- W4386850660 cites W2913190706 @default.
- W4386850660 cites W2944466104 @default.
- W4386850660 cites W2954433278 @default.
- W4386850660 cites W2959248466 @default.
- W4386850660 cites W2966787352 @default.
- W4386850660 cites W2968731587 @default.
- W4386850660 cites W2998868057 @default.
- W4386850660 cites W3000302655 @default.
- W4386850660 cites W3006865792 @default.
- W4386850660 cites W3033833760 @default.
- W4386850660 cites W3036287249 @default.
- W4386850660 cites W3038922487 @default.
- W4386850660 cites W3040580588 @default.
- W4386850660 cites W3049421282 @default.
- W4386850660 cites W3079840747 @default.
- W4386850660 cites W3083935156 @default.
- W4386850660 cites W3086050244 @default.
- W4386850660 cites W3092480329 @default.
- W4386850660 cites W3119005666 @default.
- W4386850660 cites W3132907717 @default.
- W4386850660 cites W3136390108 @default.
- W4386850660 cites W3136974273 @default.
- W4386850660 cites W3161328024 @default.
- W4386850660 cites W3162232665 @default.
- W4386850660 cites W3167845759 @default.
- W4386850660 cites W3170122359 @default.
- W4386850660 cites W3177828909 @default.
- W4386850660 cites W3179495039 @default.
- W4386850660 cites W3197832424 @default.
- W4386850660 cites W3215732879 @default.
- W4386850660 cites W3217487980 @default.
- W4386850660 cites W4200044556 @default.
- W4386850660 cites W4200141876 @default.
- W4386850660 cites W4200249660 @default.
- W4386850660 cites W4205210192 @default.
- W4386850660 cites W4206841660 @default.
- W4386850660 cites W4213038553 @default.
- W4386850660 cites W4220889808 @default.