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• W4386851215 endingPage "100648" @default.
• W4386851215 startingPage "100648" @default.
• W4386851215 abstract "The evaluation of biopsied solid organ tissue has long relied on visual examination using a microscope. Immunohistochemistry is critical in this process, labeling and detecting cell lineage markers and therapeutic targets. However, while the practice of immunohistochemistry has reshaped diagnostic pathology and facilitated improvements in cancer treatment, it has also been subject to pervasive challenges with respect to standardization and reproducibility. Efforts are ongoing to improve immunohistochemistry, but for some applications, the benefit of such initiatives could be impeded by its reliance on monospecific antibody-protein reagents and limited multiplexing capacity. This perspective surveys the relevant challenges facing traditional immunohistochemistry and describes how mass spectrometry, particularly liquid chromatography-tandem mass spectrometry could help alleviate problems. In particular, targeted mass spectrometry assays could facilitate measurements of individual proteins or analyte panels, using internal standards for more robust quantification and improved interlaboratory reproducibility. Meanwhile, untargeted mass spectrometry, showcased to date clinically in the form of amyloid typing, is inherently multiplexed, facilitating the detection and crude quantification of 100s to 1000s of proteins in a single analysis. Further, data-independent acquisition has yet to be applied in clinical practice, but offers particular strengths that could appeal to clinical users. Finally, we discuss the guidance that is needed to facilitate broader utilization in clinical environments and achieve standardization." @default.
• W4386851215 created "2023-09-20" @default.
• W4386851215 creator A5022925020 @default.
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• W4386851215 creator A5055624776 @default.
• W4386851215 creator A5060215035 @default.
• W4386851215 creator A5072278856 @default.
• W4386851215 date "2023-09-01" @default.
• W4386851215 modified "2023-09-27" @default.
• W4386851215 title "Clinical Proteomics for Solid Organ Tissues" @default.
• W4386851215 cites W1487623397 @default.
• W4386851215 cites W1511299470 @default.
• W4386851215 cites W1592986776 @default.
• W4386851215 cites W177945679 @default.
• W4386851215 cites W1796636701 @default.
• W4386851215 cites W1867967459 @default.
• W4386851215 cites W1956163040 @default.
• W4386851215 cites W1968063944 @default.
• W4386851215 cites W1972955523 @default.
• W4386851215 cites W1978083401 @default.
• W4386851215 cites W1981738763 @default.
• W4386851215 cites W1983735838 @default.
• W4386851215 cites W1983882607 @default.
• W4386851215 cites W1984831472 @default.
• W4386851215 cites W1997241015 @default.
• W4386851215 cites W1998474909 @default.
• W4386851215 cites W2004856662 @default.
• W4386851215 cites W2005568246 @default.
• W4386851215 cites W2008691121 @default.
• W4386851215 cites W2012074084 @default.
• W4386851215 cites W2013164988 @default.
• W4386851215 cites W2014433399 @default.
• W4386851215 cites W2016995421 @default.
• W4386851215 cites W2017553956 @default.
• W4386851215 cites W2020632674 @default.
• W4386851215 cites W2020958122 @default.
• W4386851215 cites W2024087792 @default.
• W4386851215 cites W2029230372 @default.
• W4386851215 cites W2030435142 @default.
• W4386851215 cites W2032323655 @default.
• W4386851215 cites W2033453797 @default.
• W4386851215 cites W2039946906 @default.
• W4386851215 cites W204213534 @default.
• W4386851215 cites W2043565262 @default.
• W4386851215 cites W2044712639 @default.
• W4386851215 cites W2045585908 @default.
• W4386851215 cites W2050664701 @default.
• W4386851215 cites W2053129129 @default.
• W4386851215 cites W2053894359 @default.
• W4386851215 cites W2057399242 @default.
• W4386851215 cites W2059674294 @default.
• W4386851215 cites W2060937867 @default.
• W4386851215 cites W2061981862 @default.
• W4386851215 cites W2062859898 @default.
• W4386851215 cites W2063123407 @default.
• W4386851215 cites W2069114336 @default.
• W4386851215 cites W2076138205 @default.
• W4386851215 cites W2079843936 @default.
• W4386851215 cites W2089243059 @default.
• W4386851215 cites W2090842981 @default.
• W4386851215 cites W2094133020 @default.
• W4386851215 cites W2104155372 @default.
• W4386851215 cites W2106156541 @default.
• W4386851215 cites W2109874651 @default.
• W4386851215 cites W2117080547 @default.
• W4386851215 cites W2117942877 @default.
• W4386851215 cites W2122360935 @default.
• W4386851215 cites W2126925889 @default.
• W4386851215 cites W2127237559 @default.
• W4386851215 cites W2130012686 @default.
• W4386851215 cites W2130075881 @default.
• W4386851215 cites W2130154577 @default.
• W4386851215 cites W2134247833 @default.
• W4386851215 cites W2134898483 @default.
• W4386851215 cites W2142256955 @default.
• W4386851215 cites W2145310592 @default.
• W4386851215 cites W2148197707 @default.
• W4386851215 cites W2156394972 @default.
• W4386851215 cites W2156953005 @default.
• W4386851215 cites W2165208460 @default.
• W4386851215 cites W2167728354 @default.
• W4386851215 cites W2168110569 @default.
• W4386851215 cites W2178051497 @default.
• W4386851215 cites W2196002378 @default.
• W4386851215 cites W2216452883 @default.
• W4386851215 cites W2313734891 @default.
• W4386851215 cites W2328648438 @default.
• W4386851215 cites W2328762559 @default.
• W4386851215 cites W2406757460 @default.
• W4386851215 cites W2433894808 @default.
• W4386851215 cites W2436516455 @default.
• W4386851215 cites W2486429036 @default.
• W4386851215 cites W2510102084 @default.
• W4386851215 cites W2511375217 @default.
• W4386851215 cites W2518302135 @default.
• W4386851215 cites W2525616756 @default.
• W4386851215 cites W2545403780 @default.

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