FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386852170> ?p ?o ?g. }

• W4386852170 endingPage "31" @default.
• W4386852170 startingPage "27" @default.
• W4386852170 abstract "Smoking, alcohol use, and non-prescription drug use are associated with worsened COVID-19 outcomes in hospitalized patients. Whether there is an association between substance use and outcomes in patients with COVID-19 who visited the Emergency Department (ED) but did not require hospitalization has not been well established. We investigated whether smoking, alcohol, and non-prescription drug use were associated with worsened COVID-19 outcomes among such patients presenting to the ED. We conducted a secondary analysis of a clinical trial which sought to determine the effect of early convalescent plasma administration in patients presenting to the ED within 7 days of onset of mild COVID-19 symptoms. The study recruited 511 participants who were aged 50 years or older or had one or more risk factors for severe COVID-19. The primary outcome was disease progression within 15 days after randomization, which was defined as a composite of hospital admission for any reason, seeking emergency or urgent care, or death without hospitalization. Secondary outcomes included: no hospitalization within 30 days post-randomization, symptom worsening on the 5-category COVID-19 outpatient ordinal scale within 15 days post-randomization, and all-cause mortality. Substance use was categorized into either use or never use based on participant self-report. Logistic regression models were used to determine the association between substance use and outcomes. The mean age of the 511 patients enrolled was 52 years and the majority were females (274, 54%). Approximately 213 (42%) were non-Hispanic Whites, 156 (30%) Hispanics, 100 (20%) non-Hispanic Blacks, 18 (4%) non-Hispanic Asian, 8 (1%) American Indian Alaskan, and 16 (3%) unknown race. Tobacco 152 (30%) was the most common substance use reported. Alcohol use 36 (7%) and non-prescription drug use 33 (6%) were less common. Tobacco use and non-prescription drug use were associated with an increased risk for meeting the primary outcome ((tobacco: adjusted odds ratio [aOR] =2.08; 95% confidence interval [CI]: 1.37–3.15) and (drug: aOR =2.41; 95%CI: 1.17–5.00)) and increased risk for symptom worsening on the 5-category COVID-19 outpatient scale ((tobacco: aOR = 1.62; 95%CI: 1.09–2.42) and (drug: aOR = 2.32 95% CI: 1.10–4.87)) compared to non-use after adjusting for age, sex, plasma administration, and comorbidity. Tobacco and non-prescription drug use but not alcohol use were associated with worsened COVID-19 outcomes in patients who did not require hospitalization on their initial presentation. Future studies should determine the quantity, duration, and type of drug/tobacco use that may worsen COVID-19." @default.
• W4386852170 created "2023-09-20" @default.
• W4386852170 creator A5001626092 @default.
• W4386852170 creator A5008873543 @default.
• W4386852170 creator A5018180596 @default.
• W4386852170 creator A5022068495 @default.
• W4386852170 creator A5028491207 @default.
• W4386852170 creator A5058710409 @default.
• W4386852170 creator A5087484208 @default.
• W4386852170 creator A5089320680 @default.
• W4386852170 date "2023-12-01" @default.
• W4386852170 modified "2023-10-18" @default.
• W4386852170 title "Association of substance use with outcomes in mildly ill COVID-19 outpatients" @default.
• W4386852170 cites W1968449615 @default.
• W4386852170 cites W1970948379 @default.
• W4386852170 cites W1993551530 @default.
• W4386852170 cites W2048351247 @default.
• W4386852170 cites W2108654808 @default.
• W4386852170 cites W2141249815 @default.
• W4386852170 cites W2518262606 @default.
• W4386852170 cites W2759338004 @default.
• W4386852170 cites W2775976478 @default.
• W4386852170 cites W3015890581 @default.
• W4386852170 cites W3020646040 @default.
• W4386852170 cites W3024894164 @default.
• W4386852170 cites W3034858522 @default.
• W4386852170 cites W3036134447 @default.
• W4386852170 cites W3042978485 @default.
• W4386852170 cites W3046383044 @default.
• W4386852170 cites W3086642606 @default.
• W4386852170 cites W3090386622 @default.
• W4386852170 cites W3094123667 @default.
• W4386852170 cites W3095229830 @default.
• W4386852170 cites W3111018792 @default.
• W4386852170 cites W3126259727 @default.
• W4386852170 cites W3195430468 @default.
• W4386852170 cites W4226523125 @default.
• W4386852170 doi "https://doi.org/10.1016/j.ajem.2023.09.017" @default.
• W4386852170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37748266" @default.
• W4386852170 hasPublicationYear "2023" @default.
• W4386852170 type Work @default.
• W4386852170 citedByCount "0" @default.
• W4386852170 crossrefType "journal-article" @default.
• W4386852170 hasAuthorship W4386852170A5001626092 @default.
• W4386852170 hasAuthorship W4386852170A5008873543 @default.
• W4386852170 hasAuthorship W4386852170A5018180596 @default.
• W4386852170 hasAuthorship W4386852170A5022068495 @default.
• W4386852170 hasAuthorship W4386852170A5028491207 @default.
• W4386852170 hasAuthorship W4386852170A5058710409 @default.
• W4386852170 hasAuthorship W4386852170A5087484208 @default.
• W4386852170 hasAuthorship W4386852170A5089320680 @default.
• W4386852170 hasConcept C118552586 @default.
• W4386852170 hasConcept C126322002 @default.
• W4386852170 hasConcept C151956035 @default.
• W4386852170 hasConcept C194828623 @default.
• W4386852170 hasConcept C204243189 @default.
• W4386852170 hasConcept C2426938 @default.
• W4386852170 hasConcept C2780724011 @default.
• W4386852170 hasConcept C30036603 @default.
• W4386852170 hasConcept C535046627 @default.
• W4386852170 hasConcept C71924100 @default.
• W4386852170 hasConcept C98274493 @default.
• W4386852170 hasConceptScore W4386852170C118552586 @default.
• W4386852170 hasConceptScore W4386852170C126322002 @default.
• W4386852170 hasConceptScore W4386852170C151956035 @default.
• W4386852170 hasConceptScore W4386852170C194828623 @default.
• W4386852170 hasConceptScore W4386852170C204243189 @default.
• W4386852170 hasConceptScore W4386852170C2426938 @default.
• W4386852170 hasConceptScore W4386852170C2780724011 @default.
• W4386852170 hasConceptScore W4386852170C30036603 @default.
• W4386852170 hasConceptScore W4386852170C535046627 @default.
• W4386852170 hasConceptScore W4386852170C71924100 @default.
• W4386852170 hasConceptScore W4386852170C98274493 @default.
• W4386852170 hasFunder F4320332161 @default.
• W4386852170 hasFunder F4320337338 @default.
• W4386852170 hasLocation W43868521701 @default.
• W4386852170 hasLocation W43868521702 @default.
• W4386852170 hasOpenAccess W4386852170 @default.
• W4386852170 hasPrimaryLocation W43868521701 @default.
• W4386852170 hasRelatedWork W1982297906 @default.
• W4386852170 hasRelatedWork W2026095104 @default.
• W4386852170 hasRelatedWork W2285736578 @default.
• W4386852170 hasRelatedWork W2375684481 @default.
• W4386852170 hasRelatedWork W2741993019 @default.
• W4386852170 hasRelatedWork W2986237400 @default.
• W4386852170 hasRelatedWork W3128428782 @default.
• W4386852170 hasRelatedWork W3210863890 @default.
• W4386852170 hasRelatedWork W3211229485 @default.
• W4386852170 hasRelatedWork W4225911821 @default.
• W4386852170 hasVolume "74" @default.
• W4386852170 isParatext "false" @default.
• W4386852170 isRetracted "false" @default.
• W4386852170 workType "article" @default.