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- W4386853645 abstract "ABSTRACT Adenosine-to-inosine (A-to-I) RNA editing plays an important role in the post-transcriptional regulation of eukaryotic cell physiology. However, our understanding of the occurrence, function and regulation of A-to-I editing in bacteria remains limited. Bacterial mRNA editing is catalysed by the deaminase TadA, which was originally described to modify a single tRNA in E. coli . Intriguingly, several bacterial species appear to perform A-to-I editing on more than one tRNA. Here, we provide evidence that in the human pathogen Streptococcus pyogenes , tRNA editing has expanded to an additional tRNA substrate. Using RNA sequencing, we identified more than 27 editing sites in the transcriptome of S. pyogenes SF370 and demonstrate that the adaptation of S. pyogenes TadA to a second tRNA substrate has also diversified the sequence context and recoding scope of mRNA editing. Based on the observation that editing is dynamically regulated in response to several infection-relevant stimuli, such as oxidative stress, we further investigated the underlying determinants of editing dynamics and identified mRNA stability as a key modulator of A-to-I editing. Overall, our findings reveal the presence and diversification of A-to-I editing in S. pyogenes and provide novel insights into the plasticity of the editome and its regulation in bacteria. GRAPHICAL ABSTRACT" @default.
- W4386853645 created "2023-09-20" @default.
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- W4386853645 date "2023-09-19" @default.
- W4386853645 modified "2023-09-29" @default.
- W4386853645 title "Dynamics of diversified A-to-I editing in<i>Streptococcus pyogenes</i>is governed by changes in mRNA stability" @default.
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- W4386853645 doi "https://doi.org/10.1101/2023.09.19.555891" @default.
- W4386853645 hasPublicationYear "2023" @default.
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