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- W4386858001 abstract "Abstract Antibiotics are increasingly recognized as causing neuropsychiatric side effects including depression and anxiety. Alterations in central serotonin and 5-HT receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with gastrointestinal disorders. Nevertheless, it is still unclear how antibiotics can cause anxiety and depression. In this study, oral administration of cefaclor, a second-generation cephalosporin antibiotic, induced anxiety- and depression-like behaviors and colitis with gut microbiota alteration in mice. Cefaclor reduced serotonin levels and fluctuated 5-HT receptor mRNA expressions such as Htr1a , Htr1b , and Htr6 in the hippocampus. Vagotomy attenuated the cefaclor-induced anxiety- and depression-like symptoms, while the cefaclor-induced changes in gut bacteria alteration and colitis were not affected. Fluoxetine attenuated cefaclor-induced anxiety- and depression-like behaviors. Furthermore, fluoxetine decreased cefaclor-resistant Enterobacteriaceae and Enterococcaceae . Taken together, our findings suggest that the use of antibiotics, particularly, cefaclor may cause gut dysbiosis-dependent anxiety and depression through the microbiota-gut-blood–brain and microbiota-gut-vagus nerve-brain pathway. Targeting antibiotics-resistant pathogenic bacteria may be a promising therapeutic strategy for the treatment of anxiety and depression." @default.
- W4386858001 created "2023-09-20" @default.
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- W4386858001 creator A5062339640 @default.
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- W4386858001 date "2023-09-19" @default.
- W4386858001 modified "2023-10-14" @default.
- W4386858001 title "Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice" @default.
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- W4386858001 doi "https://doi.org/10.1038/s41598-023-42690-1" @default.
- W4386858001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37726354" @default.
- W4386858001 hasPublicationYear "2023" @default.
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