FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386859742> ?p ?o ?g. }

• W4386859742 abstract "Evidence is needed on the risks and benefits of combination therapy with Levothyroxine (LT4) + Liothyronine (LT3) for treatment of hypothyroidism.We performed a randomized double-blind placebo-controlled study to assess the effects of LT4 + LT3 therapy vs LT4 + placebo in a homogenous group of athyreotic patients, without cardiovascular risk factors during long-term replacement monotherapy with LT4. The primary objective of the study was to assess the effects of combination LT4 + LT3 therapy on heart rate, cardiac rhythm and sensitive cardiovascular parameters of cardiac morphology and function by means of electrocardiography and Doppler echocardiography. The secondary objective of the study was to evaluate patient compliance, tolerability, and potential adverse events.Thirty-eight patients with post-surgical hypothyroidism satisfying the inclusion criteria were selected form a group of three hundred patients with low-risk thyroid cancer followed for a routine follow-up; they were randomized to receive LT4 + LT3 or LT4 + placebo. Twenty-four patients were evaluated after one year of treatment. All clinical and laboratory parameters were compared to the results obtained in fifty healthy euthyroid volunteers without comorbidities, matched for gender, age, physical activity and lifestyle. Participants and clinicians remained blinded to the treatment allocation. After one year of combination therapy, a significant improvement in the diastolic function, evidenced by a significant reduction in the E/e' ratio (p =0.046) and its positive trend over time, was observed in the LT4 + LT3 group vs. the LT4 + placebo group. In addition, the univariate analyses showed a significant relationship between F-T3 levels (pg/ml) with Δ of variation of E/e' ratio in LT4 + LT3 group. (Standardized ß coefficient = 0.603 (CI 95%: 0.001 - 1.248), p-value = 0.050) after combination therapy. No adverse events including tachycardia, arrhythmias, atrial fibrillation, or other important events occurred between the first administration and the end of the study.In this preliminary report, combination treatment with LT4 + LT3 induced favorable changes in cardiovascular parameters of diastolic function without any adverse cardiovascular events.EUDRACT n: 2017-001261-25." @default.
• W4386859742 created "2023-09-20" @default.
• W4386859742 creator A5032851558 @default.
• W4386859742 creator A5052295592 @default.
• W4386859742 creator A5064261053 @default.
• W4386859742 creator A5067992701 @default.
• W4386859742 creator A5073036953 @default.
• W4386859742 date "2023-09-19" @default.
• W4386859742 modified "2023-09-27" @default.
• W4386859742 title "PRELIMINARY RESULTS OF A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL EVALUATING THE CARDIO-METABOLIC EFFECTS OF LEVOTHYROXINE AND LIOTHYRONINE COMPARED TO LEVOTHYROXINE WITH PLACEBO IN ATHYREOTIC LOW RISK THYROID CANCER PATIENTS" @default.
• W4386859742 cites W1747119434 @default.
• W4386859742 cites W1964205598 @default.
• W4386859742 cites W2004525296 @default.
• W4386859742 cites W2046186891 @default.
• W4386859742 cites W2049954330 @default.
• W4386859742 cites W2054161925 @default.
• W4386859742 cites W2059487357 @default.
• W4386859742 cites W2074798205 @default.
• W4386859742 cites W2096560123 @default.
• W4386859742 cites W2099614776 @default.
• W4386859742 cites W2108263652 @default.
• W4386859742 cites W2120985321 @default.
• W4386859742 cites W2145150141 @default.
• W4386859742 cites W2151671899 @default.
• W4386859742 cites W2163820892 @default.
• W4386859742 cites W2165188459 @default.
• W4386859742 cites W2289684156 @default.
• W4386859742 cites W2313186535 @default.
• W4386859742 cites W2490875036 @default.
• W4386859742 cites W2527838986 @default.
• W4386859742 cites W2611024120 @default.
• W4386859742 cites W2787201390 @default.
• W4386859742 cites W2792411929 @default.
• W4386859742 cites W2797362459 @default.
• W4386859742 cites W2900160102 @default.
• W4386859742 cites W2902292705 @default.
• W4386859742 cites W3106666427 @default.
• W4386859742 cites W3175268859 @default.
• W4386859742 cites W3191235977 @default.
• W4386859742 cites W4249896096 @default.
• W4386859742 cites W4280501309 @default.
• W4386859742 cites W4295078740 @default.
• W4386859742 doi "https://doi.org/10.1089/thy.2023.0135" @default.
• W4386859742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37725587" @default.
• W4386859742 hasPublicationYear "2023" @default.
• W4386859742 type Work @default.
• W4386859742 citedByCount "0" @default.
• W4386859742 crossrefType "journal-article" @default.
• W4386859742 hasAuthorship W4386859742A5032851558 @default.
• W4386859742 hasAuthorship W4386859742A5052295592 @default.
• W4386859742 hasAuthorship W4386859742A5064261053 @default.
• W4386859742 hasAuthorship W4386859742A5067992701 @default.
• W4386859742 hasAuthorship W4386859742A5073036953 @default.
• W4386859742 hasConcept C126322002 @default.
• W4386859742 hasConcept C142724271 @default.
• W4386859742 hasConcept C168563851 @default.
• W4386859742 hasConcept C197934379 @default.
• W4386859742 hasConcept C204787440 @default.
• W4386859742 hasConcept C27081682 @default.
• W4386859742 hasConcept C2775883008 @default.
• W4386859742 hasConcept C2777195454 @default.
• W4386859742 hasConcept C2778375690 @default.
• W4386859742 hasConcept C2778840127 @default.
• W4386859742 hasConcept C2993291352 @default.
• W4386859742 hasConcept C526584372 @default.
• W4386859742 hasConcept C71924100 @default.
• W4386859742 hasConceptScore W4386859742C126322002 @default.
• W4386859742 hasConceptScore W4386859742C142724271 @default.
• W4386859742 hasConceptScore W4386859742C168563851 @default.
• W4386859742 hasConceptScore W4386859742C197934379 @default.
• W4386859742 hasConceptScore W4386859742C204787440 @default.
• W4386859742 hasConceptScore W4386859742C27081682 @default.
• W4386859742 hasConceptScore W4386859742C2775883008 @default.
• W4386859742 hasConceptScore W4386859742C2777195454 @default.
• W4386859742 hasConceptScore W4386859742C2778375690 @default.
• W4386859742 hasConceptScore W4386859742C2778840127 @default.
• W4386859742 hasConceptScore W4386859742C2993291352 @default.
• W4386859742 hasConceptScore W4386859742C526584372 @default.
• W4386859742 hasConceptScore W4386859742C71924100 @default.
• W4386859742 hasLocation W43868597421 @default.
• W4386859742 hasLocation W43868597422 @default.
• W4386859742 hasOpenAccess W4386859742 @default.
• W4386859742 hasPrimaryLocation W43868597421 @default.
• W4386859742 hasRelatedWork W1976558907 @default.
• W4386859742 hasRelatedWork W2000019451 @default.
• W4386859742 hasRelatedWork W2041009905 @default.
• W4386859742 hasRelatedWork W2059668444 @default.
• W4386859742 hasRelatedWork W2076605774 @default.
• W4386859742 hasRelatedWork W2110436471 @default.
• W4386859742 hasRelatedWork W2140359240 @default.
• W4386859742 hasRelatedWork W2606414032 @default.
• W4386859742 hasRelatedWork W2900787230 @default.
• W4386859742 hasRelatedWork W1510293505 @default.
• W4386859742 isParatext "false" @default.
• W4386859742 isRetracted "false" @default.
• W4386859742 workType "article" @default.