FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386860232> ?p ?o ?g. }

• W4386860232 endingPage "14241" @default.
• W4386860232 startingPage "14241" @default.
• W4386860232 abstract "Telomeres play pivotal roles in processes closely related to somatic senescence and aging, making them a compelling target for interventions aimed at combating aging and age-related pathologies. Ginsenoside, a natural compound, has emerged as a potential remedy for promoting healthy aging, yet how it protects telomeres remains incompletely understood. Here, we show that treatment of F1 can effectively restore the level of TRF2, thereby preserving telomere integrity. This restoration leads to inhibition of the DNA damage response and improvements in mitochondrial function and, ultimately, delays in cellular senescence. Conversely, depletion of TRF2 causes mitochondrial dysfunction, accompanied by increased oxidative stress, autophagy inhibition, insufficient energy metabolism, and the onset of cellular senescence. These observations underscore the critical role of TRF2 in maintaining telomere integrity and direct association with the initiation of cellular senescence. We conduct a further analysis, suggesting F1 could bind in proximity to the TRF2 heterodimer interface, potentially enhancing dimerization stability. These findings suggest that F1 may be a promising natural remedy for anti-aging, and restoring TRF2 could potentially prevent telomere-dependent diseases commonly associated with the aging process." @default.
• W4386860232 created "2023-09-20" @default.
• W4386860232 creator A5017735053 @default.
• W4386860232 creator A5017950579 @default.
• W4386860232 creator A5062201297 @default.
• W4386860232 creator A5071120386 @default.
• W4386860232 creator A5071537667 @default.
• W4386860232 date "2023-09-19" @default.
• W4386860232 modified "2023-10-14" @default.
• W4386860232 title "Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence" @default.
• W4386860232 cites W1594652218 @default.
• W4386860232 cites W1653749976 @default.
• W4386860232 cites W1973483964 @default.
• W4386860232 cites W1989273717 @default.
• W4386860232 cites W2005083925 @default.
• W4386860232 cites W2012099961 @default.
• W4386860232 cites W2014320780 @default.
• W4386860232 cites W2024733002 @default.
• W4386860232 cites W2026180657 @default.
• W4386860232 cites W2049680139 @default.
• W4386860232 cites W2062643118 @default.
• W4386860232 cites W2124098526 @default.
• W4386860232 cites W2126525177 @default.
• W4386860232 cites W2127175247 @default.
• W4386860232 cites W2141926462 @default.
• W4386860232 cites W2152460540 @default.
• W4386860232 cites W2157771740 @default.
• W4386860232 cites W2167285829 @default.
• W4386860232 cites W2279382765 @default.
• W4386860232 cites W2465907273 @default.
• W4386860232 cites W2568069475 @default.
• W4386860232 cites W2749713157 @default.
• W4386860232 cites W2765122346 @default.
• W4386860232 cites W2793474173 @default.
• W4386860232 cites W2971360118 @default.
• W4386860232 cites W2971858513 @default.
• W4386860232 cites W2986734872 @default.
• W4386860232 cites W3087623478 @default.
• W4386860232 cites W3105869237 @default.
• W4386860232 cites W3109939438 @default.
• W4386860232 cites W3119985674 @default.
• W4386860232 cites W3155695786 @default.
• W4386860232 cites W3191815975 @default.
• W4386860232 cites W4206506537 @default.
• W4386860232 cites W4211238779 @default.
• W4386860232 cites W4306941894 @default.
• W4386860232 doi "https://doi.org/10.3390/ijms241814241" @default.
• W4386860232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37762556" @default.
• W4386860232 hasPublicationYear "2023" @default.
• W4386860232 type Work @default.
• W4386860232 citedByCount "0" @default.
• W4386860232 crossrefType "journal-article" @default.
• W4386860232 hasAuthorship W4386860232A5017735053 @default.
• W4386860232 hasAuthorship W4386860232A5017950579 @default.
• W4386860232 hasAuthorship W4386860232A5062201297 @default.
• W4386860232 hasAuthorship W4386860232A5071120386 @default.
• W4386860232 hasAuthorship W4386860232A5071537667 @default.
• W4386860232 hasBestOaLocation W43868602321 @default.
• W4386860232 hasConcept C104317684 @default.
• W4386860232 hasConcept C134305767 @default.
• W4386860232 hasConcept C143425029 @default.
• W4386860232 hasConcept C177336024 @default.
• W4386860232 hasConcept C190283241 @default.
• W4386860232 hasConcept C203522944 @default.
• W4386860232 hasConcept C2776151105 @default.
• W4386860232 hasConcept C2776759703 @default.
• W4386860232 hasConcept C28859421 @default.
• W4386860232 hasConcept C500499127 @default.
• W4386860232 hasConcept C522857546 @default.
• W4386860232 hasConcept C54355233 @default.
• W4386860232 hasConcept C552990157 @default.
• W4386860232 hasConcept C55493867 @default.
• W4386860232 hasConcept C86803240 @default.
• W4386860232 hasConcept C94581717 @default.
• W4386860232 hasConcept C95444343 @default.
• W4386860232 hasConceptScore W4386860232C104317684 @default.
• W4386860232 hasConceptScore W4386860232C134305767 @default.
• W4386860232 hasConceptScore W4386860232C143425029 @default.
• W4386860232 hasConceptScore W4386860232C177336024 @default.
• W4386860232 hasConceptScore W4386860232C190283241 @default.
• W4386860232 hasConceptScore W4386860232C203522944 @default.
• W4386860232 hasConceptScore W4386860232C2776151105 @default.
• W4386860232 hasConceptScore W4386860232C2776759703 @default.
• W4386860232 hasConceptScore W4386860232C28859421 @default.
• W4386860232 hasConceptScore W4386860232C500499127 @default.
• W4386860232 hasConceptScore W4386860232C522857546 @default.
• W4386860232 hasConceptScore W4386860232C54355233 @default.
• W4386860232 hasConceptScore W4386860232C552990157 @default.
• W4386860232 hasConceptScore W4386860232C55493867 @default.
• W4386860232 hasConceptScore W4386860232C86803240 @default.
• W4386860232 hasConceptScore W4386860232C94581717 @default.
• W4386860232 hasConceptScore W4386860232C95444343 @default.
• W4386860232 hasIssue "18" @default.
• W4386860232 hasLocation W43868602321 @default.
• W4386860232 hasLocation W43868602322 @default.
• W4386860232 hasOpenAccess W4386860232 @default.
• W4386860232 hasPrimaryLocation W43868602321 @default.
• W4386860232 hasRelatedWork W1549945502 @default.

• next