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• W4386860345 endingPage "103774" @default.
• W4386860345 startingPage "103774" @default.
• W4386860345 abstract "Regulated induced proximity targeting chimeras (RIPTACs), a new class of heterobifunctional molecules, show promise in specifically targeting and eliminating cancer cells while leaving healthy cells unharmed. As a groundbreaking drug discovery approach, RIPTACs work by forming a stable complex with two proteins, one specifically found in cancer cells (target protein, TP) and the other pan-essential for cell survival (effector protein, EP), selectively disrupting the function of the EP in cancer cells and causing cell death. Interestingly, the TPs need not be linked to disease progression, broadening the spectrum of potential drug targets. This review summarizes the discovery and recent advances of the RIPTAC strategy. Additionally, it discusses the associated opportunities and challenges as well as future perspectives in this field." @default.
• W4386860345 created "2023-09-20" @default.
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• W4386860345 date "2023-11-01" @default.
• W4386860345 modified "2023-10-06" @default.
• W4386860345 title "RIPTACs: A groundbreaking approach to drug discovery" @default.
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• W4386860345 doi "https://doi.org/10.1016/j.drudis.2023.103774" @default.
• W4386860345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37734702" @default.
• W4386860345 hasPublicationYear "2023" @default.
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