Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386861011> ?p ?o ?g. }
- W4386861011 abstract "The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals not only have nine morphologically described cell types and no neurons but also show coordinated behaviors triggered by peptide-secreting cells. We investigated possible neuronal affinities of these peptidergic cells using phylogenetics, chromatin profiling, and comparative single-cell genomics in four placozoans. We found conserved cell type expression programs across placozoans, including populations of transdifferentiating and cycling cells, suggestive of active cell type homeostasis. We also uncovered fourteen peptidergic cell types expressing neuronal-associated components like the pre-synaptic scaffold that derive from progenitor cells with neurogenesis signatures. In contrast, earlier-branching animals like sponges and ctenophores lacked this conserved expression. Our findings indicate that key neuronal developmental and effector gene modules evolved before the advent of cnidarian/bilaterian neurons in the context of paracrine cell signaling." @default.
- W4386861011 created "2023-09-20" @default.
- W4386861011 creator A5004697708 @default.
- W4386861011 creator A5013227387 @default.
- W4386861011 creator A5026423295 @default.
- W4386861011 creator A5031956025 @default.
- W4386861011 creator A5037226224 @default.
- W4386861011 creator A5037810228 @default.
- W4386861011 creator A5052227464 @default.
- W4386861011 creator A5052488118 @default.
- W4386861011 creator A5067759777 @default.
- W4386861011 creator A5071122911 @default.
- W4386861011 creator A5080707475 @default.
- W4386861011 creator A5083938084 @default.
- W4386861011 creator A5086902445 @default.
- W4386861011 creator A5092902103 @default.
- W4386861011 date "2023-09-01" @default.
- W4386861011 modified "2023-10-13" @default.
- W4386861011 title "Stepwise emergence of the neuronal gene expression program in early animal evolution" @default.
- W4386861011 cites W1664750859 @default.
- W4386861011 cites W1966327575 @default.
- W4386861011 cites W1981593008 @default.
- W4386861011 cites W1984048199 @default.
- W4386861011 cites W1984520680 @default.
- W4386861011 cites W1987301268 @default.
- W4386861011 cites W2001936817 @default.
- W4386861011 cites W2002093986 @default.
- W4386861011 cites W2005412859 @default.
- W4386861011 cites W2006387377 @default.
- W4386861011 cites W2010238279 @default.
- W4386861011 cites W2013410948 @default.
- W4386861011 cites W2014677321 @default.
- W4386861011 cites W2020680099 @default.
- W4386861011 cites W2026775160 @default.
- W4386861011 cites W2027035529 @default.
- W4386861011 cites W2027906967 @default.
- W4386861011 cites W2030148675 @default.
- W4386861011 cites W2033169664 @default.
- W4386861011 cites W2041612616 @default.
- W4386861011 cites W2044120209 @default.
- W4386861011 cites W2049017883 @default.
- W4386861011 cites W2079614890 @default.
- W4386861011 cites W2097705657 @default.
- W4386861011 cites W2100886237 @default.
- W4386861011 cites W2102652793 @default.
- W4386861011 cites W2103441770 @default.
- W4386861011 cites W2114416522 @default.
- W4386861011 cites W2117801354 @default.
- W4386861011 cites W2120024428 @default.
- W4386861011 cites W2124166542 @default.
- W4386861011 cites W2124772083 @default.
- W4386861011 cites W2131478115 @default.
- W4386861011 cites W2141287548 @default.
- W4386861011 cites W2146127418 @default.
- W4386861011 cites W2147307434 @default.
- W4386861011 cites W2147373929 @default.
- W4386861011 cites W2152298208 @default.
- W4386861011 cites W2152770371 @default.
- W4386861011 cites W2153796465 @default.
- W4386861011 cites W2156247618 @default.
- W4386861011 cites W2158723722 @default.
- W4386861011 cites W2160378127 @default.
- W4386861011 cites W2160586365 @default.
- W4386861011 cites W2163627198 @default.
- W4386861011 cites W2165102934 @default.
- W4386861011 cites W2167852161 @default.
- W4386861011 cites W2168570965 @default.
- W4386861011 cites W2168573791 @default.
- W4386861011 cites W2169456326 @default.
- W4386861011 cites W2171808845 @default.
- W4386861011 cites W2177494588 @default.
- W4386861011 cites W2255210411 @default.
- W4386861011 cites W2323326409 @default.
- W4386861011 cites W2329988967 @default.
- W4386861011 cites W2341539131 @default.
- W4386861011 cites W2406250479 @default.
- W4386861011 cites W2460791617 @default.
- W4386861011 cites W2481000200 @default.
- W4386861011 cites W2553676377 @default.
- W4386861011 cites W2561512859 @default.
- W4386861011 cites W2597136739 @default.
- W4386861011 cites W2614029615 @default.
- W4386861011 cites W2614081736 @default.
- W4386861011 cites W2616922646 @default.
- W4386861011 cites W2735451764 @default.
- W4386861011 cites W2738668379 @default.
- W4386861011 cites W2750416916 @default.
- W4386861011 cites W2754832607 @default.
- W4386861011 cites W2775427740 @default.
- W4386861011 cites W2784155653 @default.
- W4386861011 cites W2785792383 @default.
- W4386861011 cites W2800301968 @default.
- W4386861011 cites W2800580754 @default.
- W4386861011 cites W2807587036 @default.
- W4386861011 cites W2809507176 @default.
- W4386861011 cites W2883251903 @default.
- W4386861011 cites W2894687190 @default.
- W4386861011 cites W2898892386 @default.
- W4386861011 cites W2908903363 @default.
- W4386861011 cites W2911108160 @default.