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• W4386863810 abstract "Abstract Background : Disconjugate eye movements play a crucial role in depth perception for frontal-eyed species. Midbrain lesions cause disconjugate eye movement deficits, such as skew deviation and hemi-seesaw nystagmus in the vertical plane or esodeviation and convergence-retraction nystagmus in the horizontal plane. While the former have been linked to defective visuo-vestibular interaction, the pathophysiology of the latter remains elusive. Methods & Results: We report a patient with a solitary focal midbrain lesion, presenting with both vertically and horizontally disconjugate eye movement disorders. Videooculography showed a strong correlation of vertical and horizontal oscillations during fixation but not in darkness. Oscillation intensities and waveforms were modulated by fixation, illumination and gaze position, hinting at shared visual- and vestibular-related mechanisms. Diffusion MRI, combined with co-registration to a cytoarchitectonic MR-atlas, pinpointed the lesion to a functionally ill-defined area of the dorsal midbrain, adjacent to the posterior commissure and nuclei with known roles in vertical gaze control. Conclusion : A circumscribed region in the dorsal midbrain is a key node for disconjugate eye movements across both vertical and horizontal planes. Lesioning this area produces a unique ocular motor syndrome that mirrors hallmark patterns of developmental strabismus. Further circuit-level studies could offer pivotal insights into shared pathomechanisms." @default.
• W4386863810 created "2023-09-20" @default.
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• W4386863810 date "2023-09-19" @default.
• W4386863810 modified "2023-09-27" @default.
• W4386863810 title "Midbrain lesion-induced disconjugate gaze: a unifying circuit mechanism of ocular misalignment?" @default.
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• W4386863810 doi "https://doi.org/10.21203/rs.3.rs-3356074/v1" @default.
• W4386863810 hasPublicationYear "2023" @default.
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