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- W4386865231 abstract "The modern taxonomy of disease builds a framework for precision medicine, by which traditional pathological criteria are integrated with clinical and genomic features to define disease entities. Two of the most common subtypes of lymphoma on a worldwide basis are follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). While the BCL2 translocation is the signature lesion of most nodal FL, recent studies have identified significant diversity among follicle-center derived lesions. BCL2-negative FL is a genetically heterogeneous disease that occurs in both nodal and extranodal sites. Several distinct entities have been recognized in the pediatric age group including pediatric-type FL, testicular FL, and IRF4-rearranged large B-cell lymphoma. DLBCL is a family of aggressive B-cell neoplasms with marked variation in pathogenesis and clinical features. Gene expression profiling (GEP) more than 20 years ago identified the cell of origin (COO) as a key discriminator, but more recently high throughput sequencing has identified highly varied mutational profiles that should point the way in the future towards improvements in targeted therapy and patient outcome." @default.
- W4386865231 created "2023-09-20" @default.
- W4386865231 creator A5089779163 @default.
- W4386865231 date "2023-09-01" @default.
- W4386865231 modified "2023-10-18" @default.
- W4386865231 title "Evolution of Lymphoma Diagnosis in the Era of Personalized Medicine – A Marriage of Pathology and Genomics for Clinical Practice" @default.
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- W4386865231 doi "https://doi.org/10.1016/j.ajpath.2023.08.012" @default.
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