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- W4386865487 endingPage "132575" @default.
- W4386865487 startingPage "132575" @default.
- W4386865487 abstract "Zinc pyrithione (ZPT) is widely recognized for its beneficial properties as an antifouling, antibacterial, and antifungal agent. Despite its positive industrial contributions, ZPT has been proven to exhibit toxicity towards various ecosystems, particularly affecting marine life. However, there is still a dearth of comprehensive research on ZPT toxicity and its toxicological mechanism in reproductive systems of aquatic organisms. In our study, we conducted a thorough analysis and unveiled a multitude of abnormalities in zebrafish sperm and testicular tissue caused by ZPT exposure, including a dose-dependent diminishing of testosterone levels, various sperm deformities, decreased sperm concentration and motility, and ROS-induced testicular tissue DNA damage. In addition, our study suggested that ZPT-induced testicular damage is associated with heightened oxidative stress, apoptosis, and possible hyperpolarization of the mitochondrial membrane. Through RNA-seq analysis, a total of 409 DEGs associated with ZPT-induced testicular injury were identified, and the hub gene was determined using a protein-protein interaction network (PPI). The genes and pathways uncovered in this study point to potential mechanisms of ZPT exposure on sperm and testicular injury in zebrafish." @default.
- W4386865487 created "2023-09-20" @default.
- W4386865487 creator A5003037647 @default.
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- W4386865487 date "2024-01-01" @default.
- W4386865487 modified "2023-09-30" @default.
- W4386865487 title "Toxic effects and potential mechanisms of zinc pyrithione (ZPT) exposure on sperm and testicular injury in zebrafish" @default.
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- W4386865487 doi "https://doi.org/10.1016/j.jhazmat.2023.132575" @default.
- W4386865487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37741212" @default.
- W4386865487 hasPublicationYear "2024" @default.
- W4386865487 type Work @default.