Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386868075> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4386868075 endingPage "27" @default.
- W4386868075 startingPage "18" @default.
- W4386868075 abstract "Introduction: Biocides are commonly used for disinfection in a variety of contexts. They are generally used to avoid infection by controlling biofilm on medical equipment. However, the literature lacks information on the effect of biocide on efflux pump gene expression. Objective: To determine the influence of biocide on biofilm development and efflux pump acrA and ramA gene expression. Methodology: The microtiter plate method was used to identify biofilm development in 80 isolates of K. pneumoniae. The minimal inhibitory concentrations (MIC) of three biocides (quaternary ammonium compound (QAC), chlorohexidine digluconate, and chloroxylenol) were estimated. The effect of QAC on the intensity and viability of biofilms was investigated as well. Its influence on biofilm was evaluated using scanning electron microscopy. For each isolate, gene expression of the acrA and ramA was evaluated before and after treatment with the biocide (at ½MIC). Results: The study revealed that 60% of isolates formed moderate biofilms. Biofilms of all isolates were inhibited by QAC at high concentrations. Moreover, QAC at ½MIC downregulated the gene expression of the efflux pump gene (acrA) and its regulator (ramA). Conclusion: Biofilms of all isolates were prevented by QAC at high doses. Furthermore, QAC at ½MIC decreased the expression of the efflux pump gene (acrA) and its regulator (ramA). How to cite this article:Odaa FH, Al-Mathkhury HJF. Downregulation of the Gene Expression of Efflux Pump Gene (acrA) and its Regulator (ramA) in Klebsiella pneumoniae by Quaternary Ammonium Compounds. J Commun Dis. 2023;55(2):18-27. DOI: https://doi.org/10.24321/0019.5138.202320" @default.
- W4386868075 created "2023-09-20" @default.
- W4386868075 creator A5092903643 @default.
- W4386868075 date "2023-06-23" @default.
- W4386868075 modified "2023-09-27" @default.
- W4386868075 title "Downregulation of the Gene Expression of Efflux Pump Gene (acrA) and its Regulator (ramA) in Klebsiella pneumoniae by Quaternary Ammonium Compounds" @default.
- W4386868075 doi "https://doi.org/10.24321/0019.5138.202320" @default.
- W4386868075 hasPublicationYear "2023" @default.
- W4386868075 type Work @default.
- W4386868075 citedByCount "0" @default.
- W4386868075 crossrefType "journal-article" @default.
- W4386868075 hasAuthorship W4386868075A5092903643 @default.
- W4386868075 hasBestOaLocation W43868680751 @default.
- W4386868075 hasConcept C104317684 @default.
- W4386868075 hasConcept C150194340 @default.
- W4386868075 hasConcept C178790620 @default.
- W4386868075 hasConcept C185592680 @default.
- W4386868075 hasConcept C197471484 @default.
- W4386868075 hasConcept C200082930 @default.
- W4386868075 hasConcept C2777058267 @default.
- W4386868075 hasConcept C2779870022 @default.
- W4386868075 hasConcept C523546767 @default.
- W4386868075 hasConcept C54355233 @default.
- W4386868075 hasConcept C547475151 @default.
- W4386868075 hasConcept C55493867 @default.
- W4386868075 hasConcept C58123911 @default.
- W4386868075 hasConcept C6929976 @default.
- W4386868075 hasConcept C86803240 @default.
- W4386868075 hasConcept C89423630 @default.
- W4386868075 hasConceptScore W4386868075C104317684 @default.
- W4386868075 hasConceptScore W4386868075C150194340 @default.
- W4386868075 hasConceptScore W4386868075C178790620 @default.
- W4386868075 hasConceptScore W4386868075C185592680 @default.
- W4386868075 hasConceptScore W4386868075C197471484 @default.
- W4386868075 hasConceptScore W4386868075C200082930 @default.
- W4386868075 hasConceptScore W4386868075C2777058267 @default.
- W4386868075 hasConceptScore W4386868075C2779870022 @default.
- W4386868075 hasConceptScore W4386868075C523546767 @default.
- W4386868075 hasConceptScore W4386868075C54355233 @default.
- W4386868075 hasConceptScore W4386868075C547475151 @default.
- W4386868075 hasConceptScore W4386868075C55493867 @default.
- W4386868075 hasConceptScore W4386868075C58123911 @default.
- W4386868075 hasConceptScore W4386868075C6929976 @default.
- W4386868075 hasConceptScore W4386868075C86803240 @default.
- W4386868075 hasConceptScore W4386868075C89423630 @default.
- W4386868075 hasIssue "02" @default.
- W4386868075 hasLocation W43868680751 @default.
- W4386868075 hasOpenAccess W4386868075 @default.
- W4386868075 hasPrimaryLocation W43868680751 @default.
- W4386868075 hasRelatedWork W2014090893 @default.
- W4386868075 hasRelatedWork W2139663729 @default.
- W4386868075 hasRelatedWork W2140477812 @default.
- W4386868075 hasRelatedWork W2325031717 @default.
- W4386868075 hasRelatedWork W2337769708 @default.
- W4386868075 hasRelatedWork W2401291924 @default.
- W4386868075 hasRelatedWork W2911633514 @default.
- W4386868075 hasRelatedWork W3005886271 @default.
- W4386868075 hasRelatedWork W3096215692 @default.
- W4386868075 hasRelatedWork W3165375548 @default.
- W4386868075 hasVolume "55" @default.
- W4386868075 isParatext "false" @default.
- W4386868075 isRetracted "false" @default.
- W4386868075 workType "article" @default.