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- W4386871676 abstract "Abstract Background Previous studies suggest there is an association between levels of lipoprotein a [Lp (a)] and increased cardiovascular risk in general population and familial hypercholesterolaemia patients. The purpose of this study was to define the exact relationship between the levels of Lp (a) and cardiovascular risk in a Familial Combined Hyperlipidaemia (FCH) population. Methods We enrolled 1094 (615 males, mean age 49 years old) patients who fulfilled the FCH criteria, from the outpatient lipid clinic of our hospital. Lp (a) levels were measured and information were obtained regarding demographic characteristics, the presence of coronary artery disease (CAD) and CAD risk factors. Patients were categorized initially according to baseline Lp (a) levels to quintile 1 (≤30mg/dl) (N=769), quintile 2 (>30 mg/dl, ≤50mg/dl) (N=149), quintile 3 (>50mg/dl, ≤100mg/dl) (N=124), quintile 4 (>100mg/dl, ≤150mg/dl) (N=31), and quintile 5 (>150mg/dl) (N=21). We calculated the percentage of patients with CAD in each quintile. Additionally, we performed logistic regression analysis to predict the presence of CAD based on the levels of Lp (a) and other CAD risk factors, age, sex, the presence of diabetes mellitus, hypertension and smoking. Results Mean value for Lp (a) in the whole population was 29.67mg/dl. The percentages of CAD were 13.1%, 16.8%, 15.3%, 22.6%, and 23.8% respectively for quintiles 1–5 (Figure 1). The number of CAD patients increases as baseline Lp (a) levels increase. To further support the finding, regression analysis revealed that age, gender and Lp (a) added significantly to the model. Lp (a) could predict CAD, independently of other factors. Conclusions The correlation between Lp (a) and Familial Combined Hyperlipidaemia is unclear. There is an increasing trend for the presence of CAD in higher Lp (a) levels and a positive relationship, indicating a straightforward correlation between these two parameters. Funding Acknowledgement Type of funding sources: None." @default.
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- W4386871676 date "2021-10-01" @default.
- W4386871676 modified "2023-09-27" @default.
- W4386871676 title "Lipoprotein (a) and cardiovascular risk in familial combined hyperlipidaemia: does it exist?" @default.
- W4386871676 doi "https://doi.org/10.1093/eurheartj/ehab724.2579" @default.
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