FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386873886> ?p ?o ?g. }

• W4386873886 endingPage "104803" @default.
• W4386873886 startingPage "104803" @default.
• W4386873886 abstract "Metformin shows beneficial effects on cardiometabolic health in diabetic individuals. However, the beneficial effects in the general population, especially in non-diabetic individuals are unclear. We aim to estimate the effects of perturbation of seven metformin targets on cardiometabolic health using Mendelian randomization (MR).Genetic variants close to metformin-targeted genes associated with expression of the corresponding genes and glycated haemoglobin (HbA1c) level were used to proxy therapeutic effects of seven metformin-related drug targets. Eight cardiometabolic phenotypes under metformin trials were selected as outcomes (average N = 466,947). MR estimates representing the weighted average effects of the seven effects of metformin targets on the eight outcomes were generated. One-sample MR was applied to estimate the averaged and target-specific effects in 338,425 non-diabetic individuals in UK Biobank.Genetically proxied averaged effects of five metformin targets, equivalent to a 0.62% reduction of HbA1c level, was associated with 37.8% lower risk of coronary artery disease (CAD) (odds ratio [OR] = 0.62, 95% confidence interval [CI] = 0.46-0.84), lower levels of body mass index (BMI) (β = -0.22, 95% CI = -0.35 to -0.09), systolic blood pressure (SBP) (β = -0.19, 95% CI = -0.28 to -0.09) and diastolic blood pressure (DBP) levels (β = -0.29, 95% CI = -0.39 to -0.19). One-sample MR suggested that the seven metformin targets showed averaged and target-specific beneficial effects on BMI, SBP and DBP in non-diabetic individuals.This study showed that perturbation of seven metformin targets has beneficial effects on BMI and blood pressure in non-diabetic individuals. Clinical trials are needed to investigate whether similar effects can be achieved with metformin medications.Funding information is provided in the Acknowledgements." @default.
• W4386873886 created "2023-09-20" @default.
• W4386873886 creator A5002816552 @default.
• W4386873886 creator A5008232243 @default.
• W4386873886 creator A5009102741 @default.
• W4386873886 creator A5013184354 @default.
• W4386873886 creator A5028631305 @default.
• W4386873886 creator A5034127226 @default.
• W4386873886 creator A5036589831 @default.
• W4386873886 creator A5046394904 @default.
• W4386873886 creator A5049775946 @default.
• W4386873886 creator A5050423533 @default.
• W4386873886 creator A5053235446 @default.
• W4386873886 creator A5054215561 @default.
• W4386873886 creator A5055374455 @default.
• W4386873886 creator A5066215764 @default.
• W4386873886 creator A5066907464 @default.
• W4386873886 creator A5068101221 @default.
• W4386873886 creator A5069611208 @default.
• W4386873886 creator A5080760043 @default.
• W4386873886 creator A5083595315 @default.
• W4386873886 creator A5087372897 @default.
• W4386873886 creator A5087932701 @default.
• W4386873886 date "2023-10-01" @default.
• W4386873886 modified "2023-10-15" @default.
• W4386873886 title "Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study" @default.
• W4386873886 cites W1966706887 @default.
• W4386873886 cites W1969222185 @default.
• W4386873886 cites W2002413871 @default.
• W4386873886 cites W2026413615 @default.
• W4386873886 cites W2047516613 @default.
• W4386873886 cites W2054530178 @default.
• W4386873886 cites W2073836327 @default.
• W4386873886 cites W2096559770 @default.
• W4386873886 cites W2106036991 @default.
• W4386873886 cites W2122315101 @default.
• W4386873886 cites W2140307562 @default.
• W4386873886 cites W2161310510 @default.
• W4386873886 cites W2171294019 @default.
• W4386873886 cites W2188846692 @default.
• W4386873886 cites W2324962257 @default.
• W4386873886 cites W2475125285 @default.
• W4386873886 cites W2493389217 @default.
• W4386873886 cites W2511649479 @default.
• W4386873886 cites W2528389922 @default.
• W4386873886 cites W2558443339 @default.
• W4386873886 cites W2561702225 @default.
• W4386873886 cites W2593611359 @default.
• W4386873886 cites W2740802742 @default.
• W4386873886 cites W2742200852 @default.
• W4386873886 cites W2746853643 @default.
• W4386873886 cites W2748135921 @default.
• W4386873886 cites W2750180661 @default.
• W4386873886 cites W2759628183 @default.
• W4386873886 cites W2794128897 @default.
• W4386873886 cites W2805983714 @default.
• W4386873886 cites W2809991789 @default.
• W4386873886 cites W2883415719 @default.
• W4386873886 cites W2888330909 @default.
• W4386873886 cites W2894662039 @default.
• W4386873886 cites W2900090807 @default.
• W4386873886 cites W2948412754 @default.
• W4386873886 cites W2955177623 @default.
• W4386873886 cites W2997621205 @default.
• W4386873886 cites W3003537357 @default.
• W4386873886 cites W3017015779 @default.
• W4386873886 cites W3028534533 @default.
• W4386873886 cites W3035249131 @default.
• W4386873886 cites W3047126227 @default.
• W4386873886 cites W3080477490 @default.
• W4386873886 cites W3083496521 @default.
• W4386873886 cites W3093084901 @default.
• W4386873886 cites W3093279792 @default.
• W4386873886 cites W3133859624 @default.
• W4386873886 cites W3157971051 @default.
• W4386873886 cites W3164845562 @default.
• W4386873886 cites W3193150046 @default.
• W4386873886 cites W3210570897 @default.
• W4386873886 cites W3211912548 @default.
• W4386873886 cites W4288713697 @default.
• W4386873886 doi "https://doi.org/10.1016/j.ebiom.2023.104803" @default.
• W4386873886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37734206" @default.
• W4386873886 hasPublicationYear "2023" @default.
• W4386873886 type Work @default.
• W4386873886 citedByCount "0" @default.
• W4386873886 crossrefType "journal-article" @default.
• W4386873886 hasAuthorship W4386873886A5002816552 @default.
• W4386873886 hasAuthorship W4386873886A5008232243 @default.
• W4386873886 hasAuthorship W4386873886A5009102741 @default.
• W4386873886 hasAuthorship W4386873886A5013184354 @default.
• W4386873886 hasAuthorship W4386873886A5028631305 @default.
• W4386873886 hasAuthorship W4386873886A5034127226 @default.
• W4386873886 hasAuthorship W4386873886A5036589831 @default.
• W4386873886 hasAuthorship W4386873886A5046394904 @default.
• W4386873886 hasAuthorship W4386873886A5049775946 @default.
• W4386873886 hasAuthorship W4386873886A5050423533 @default.
• W4386873886 hasAuthorship W4386873886A5053235446 @default.
• W4386873886 hasAuthorship W4386873886A5054215561 @default.

• next