Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386874154> ?p ?o ?g. }
- W4386874154 endingPage "113146" @default.
- W4386874154 startingPage "113146" @default.
- W4386874154 abstract "The retinoblastoma family proteins (RBs) and E2F transcription factors are cell-autonomous regulators of cell-cycle progression, but they also impact fate choice in addition to tumor suppression. The range of mechanisms involved remains to be uncovered. Here, we show that RBs, particularly RBL2/p130, repress WNT ligands such as WNT4 and WNT8A, thereby directing ectoderm specification between neural crest to neuroepithelium. RBL2 achieves this function through cell-cycle-dependent cooperation with E2Fs and GCN5 on the regulatory regions of WNT loci, which direct neuroepithelial versus neural crest specification by temporal fluctuations of WNT/β-catenin and DLL/NOTCH signaling activity. Thus, the RB-E2F bona fide cell-autonomous axis controls cell fate decisions, and RBL2 regulates field effects via WNT ligands. This reveals a non-cell-autonomous function of RBL2-E2F in stem cell and tissue progenitor differentiation that has broader implications for cell-cycle-dependent cell fate specification in organogenesis, adult stem cells, tissue homeostasis, and tumorigenesis." @default.
- W4386874154 created "2023-09-20" @default.
- W4386874154 creator A5000749022 @default.
- W4386874154 creator A5025529880 @default.
- W4386874154 creator A5041155406 @default.
- W4386874154 creator A5077222290 @default.
- W4386874154 date "2023-09-01" @default.
- W4386874154 modified "2023-10-15" @default.
- W4386874154 title "RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling" @default.
- W4386874154 cites W1916253178 @default.
- W4386874154 cites W1963985319 @default.
- W4386874154 cites W1965516033 @default.
- W4386874154 cites W1966276188 @default.
- W4386874154 cites W1968614642 @default.
- W4386874154 cites W1969717239 @default.
- W4386874154 cites W1972208492 @default.
- W4386874154 cites W1972741966 @default.
- W4386874154 cites W1977265727 @default.
- W4386874154 cites W1978116091 @default.
- W4386874154 cites W1978285772 @default.
- W4386874154 cites W1978914404 @default.
- W4386874154 cites W1979755285 @default.
- W4386874154 cites W1980890490 @default.
- W4386874154 cites W1981335003 @default.
- W4386874154 cites W1983318575 @default.
- W4386874154 cites W1983585255 @default.
- W4386874154 cites W1986336605 @default.
- W4386874154 cites W1986960362 @default.
- W4386874154 cites W1995869358 @default.
- W4386874154 cites W1997823361 @default.
- W4386874154 cites W2001004678 @default.
- W4386874154 cites W2011341845 @default.
- W4386874154 cites W2014677321 @default.
- W4386874154 cites W2017599618 @default.
- W4386874154 cites W2018286352 @default.
- W4386874154 cites W2022329296 @default.
- W4386874154 cites W2024047179 @default.
- W4386874154 cites W2025493456 @default.
- W4386874154 cites W2029824360 @default.
- W4386874154 cites W2030924655 @default.
- W4386874154 cites W2035975217 @default.
- W4386874154 cites W2036233315 @default.
- W4386874154 cites W2039980882 @default.
- W4386874154 cites W2042198997 @default.
- W4386874154 cites W2044484847 @default.
- W4386874154 cites W2045056792 @default.
- W4386874154 cites W2047578520 @default.
- W4386874154 cites W2050126783 @default.
- W4386874154 cites W2051445779 @default.
- W4386874154 cites W2051541258 @default.
- W4386874154 cites W2055998880 @default.
- W4386874154 cites W2061665609 @default.
- W4386874154 cites W2062265555 @default.
- W4386874154 cites W2063367127 @default.
- W4386874154 cites W2063409224 @default.
- W4386874154 cites W2068715807 @default.
- W4386874154 cites W2071427066 @default.
- W4386874154 cites W2073377349 @default.
- W4386874154 cites W2073449129 @default.
- W4386874154 cites W2076223721 @default.
- W4386874154 cites W2079883339 @default.
- W4386874154 cites W2080077392 @default.
- W4386874154 cites W2081098333 @default.
- W4386874154 cites W2085823054 @default.
- W4386874154 cites W2086082161 @default.
- W4386874154 cites W2086322317 @default.
- W4386874154 cites W2086327775 @default.
- W4386874154 cites W2086943348 @default.
- W4386874154 cites W2087057208 @default.
- W4386874154 cites W2087786585 @default.
- W4386874154 cites W2088969512 @default.
- W4386874154 cites W2090807626 @default.
- W4386874154 cites W2091159534 @default.
- W4386874154 cites W2091891304 @default.
- W4386874154 cites W2092543937 @default.
- W4386874154 cites W2095885501 @default.
- W4386874154 cites W2098268993 @default.
- W4386874154 cites W2098955488 @default.
- W4386874154 cites W2102619694 @default.
- W4386874154 cites W2103441770 @default.
- W4386874154 cites W2104660346 @default.
- W4386874154 cites W2104775085 @default.
- W4386874154 cites W2105666596 @default.
- W4386874154 cites W2106608030 @default.
- W4386874154 cites W2109829350 @default.
- W4386874154 cites W2112194595 @default.
- W4386874154 cites W2114104545 @default.
- W4386874154 cites W2115478217 @default.
- W4386874154 cites W2117131162 @default.
- W4386874154 cites W2118109822 @default.
- W4386874154 cites W2122986552 @default.
- W4386874154 cites W2131271579 @default.
- W4386874154 cites W2133465414 @default.
- W4386874154 cites W2136792748 @default.
- W4386874154 cites W2137742613 @default.
- W4386874154 cites W2140834174 @default.
- W4386874154 cites W2142370020 @default.
- W4386874154 cites W2144172863 @default.