Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386877650> ?p ?o ?g. }
- W4386877650 abstract "Abstract In eukaryotic cells, the membraneless organelles (MLOs) formed via liquid‐liquid phase separation (LLPS) are found to interact intimately with membranous organelles (MOs). One major mode is the clustering of MOs by MLOs, such as the formation of clusters of synaptic vesicles at nerve terminals mediated by the synapsin‐rich MLOs. Aqueous droplets, including complex coacervates and aqueous two‐phase systems, have been plausible MLO‐mimics to emulate or elucidate biological processes. However, neither of them can cluster lipid vesicles (LVs) like MLOs. In this work, we develop a synthetic droplet assembled from a combination of two different interactions underlying the formation of these two droplets, namely, associative and segregative interactions, which we call segregative‐associative (SA) droplets. The SA droplets cluster and disperse LVs recapitulating the key functional features of synapsin condensates, which can be attributed to the weak electrostatic interaction environment provided by SA droplets. This work suggests LLPS with combined segregative and associative interactions as a possible route for synaptic clustering of lipid vesicles and highlights SA droplets as plausible MLO‐mimics and models for studying and mimicking related cellular dynamics." @default.
- W4386877650 created "2023-09-21" @default.
- W4386877650 creator A5011705324 @default.
- W4386877650 creator A5012813068 @default.
- W4386877650 creator A5013804346 @default.
- W4386877650 creator A5031530533 @default.
- W4386877650 creator A5051158759 @default.
- W4386877650 creator A5072207899 @default.
- W4386877650 creator A5086546808 @default.
- W4386877650 date "2023-10-06" @default.
- W4386877650 modified "2023-10-09" @default.
- W4386877650 title "Synthetic Membraneless Droplets for Synaptic‐Like Clustering of Lipid Vesicles" @default.
- W4386877650 cites W117864132 @default.
- W4386877650 cites W1992230424 @default.
- W4386877650 cites W2013243958 @default.
- W4386877650 cites W2072014193 @default.
- W4386877650 cites W2082423911 @default.
- W4386877650 cites W2084781504 @default.
- W4386877650 cites W2085978470 @default.
- W4386877650 cites W2104838697 @default.
- W4386877650 cites W2268103735 @default.
- W4386877650 cites W2292279843 @default.
- W4386877650 cites W2331593876 @default.
- W4386877650 cites W2336024963 @default.
- W4386877650 cites W2408322376 @default.
- W4386877650 cites W2501424458 @default.
- W4386877650 cites W2590568317 @default.
- W4386877650 cites W2593853897 @default.
- W4386877650 cites W2760207683 @default.
- W4386877650 cites W2801978547 @default.
- W4386877650 cites W2838851331 @default.
- W4386877650 cites W2886607570 @default.
- W4386877650 cites W2888141287 @default.
- W4386877650 cites W2908663603 @default.
- W4386877650 cites W2912644423 @default.
- W4386877650 cites W2945466661 @default.
- W4386877650 cites W2952564407 @default.
- W4386877650 cites W2953495991 @default.
- W4386877650 cites W2973356406 @default.
- W4386877650 cites W2979943021 @default.
- W4386877650 cites W2988915271 @default.
- W4386877650 cites W2990596485 @default.
- W4386877650 cites W3003552173 @default.
- W4386877650 cites W3004042481 @default.
- W4386877650 cites W3004533093 @default.
- W4386877650 cites W3006964366 @default.
- W4386877650 cites W3014155975 @default.
- W4386877650 cites W3020961372 @default.
- W4386877650 cites W3033581997 @default.
- W4386877650 cites W3046158099 @default.
- W4386877650 cites W3049249652 @default.
- W4386877650 cites W3099323319 @default.
- W4386877650 cites W3104099683 @default.
- W4386877650 cites W3110145803 @default.
- W4386877650 cites W3110291084 @default.
- W4386877650 cites W3117500204 @default.
- W4386877650 cites W3118681762 @default.
- W4386877650 cites W3119560706 @default.
- W4386877650 cites W3131479422 @default.
- W4386877650 cites W3134076312 @default.
- W4386877650 cites W3146975508 @default.
- W4386877650 cites W3157262848 @default.
- W4386877650 cites W3172359530 @default.
- W4386877650 cites W3193736530 @default.
- W4386877650 cites W3205791798 @default.
- W4386877650 cites W3210490168 @default.
- W4386877650 cites W4212888384 @default.
- W4386877650 cites W4213019686 @default.
- W4386877650 cites W4290215691 @default.
- W4386877650 cites W4308834658 @default.
- W4386877650 cites W4318919118 @default.
- W4386877650 cites W4323350303 @default.
- W4386877650 doi "https://doi.org/10.1002/anie.202313096" @default.
- W4386877650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37728515" @default.
- W4386877650 hasPublicationYear "2023" @default.
- W4386877650 type Work @default.
- W4386877650 citedByCount "0" @default.
- W4386877650 crossrefType "journal-article" @default.
- W4386877650 hasAuthorship W4386877650A5011705324 @default.
- W4386877650 hasAuthorship W4386877650A5012813068 @default.
- W4386877650 hasAuthorship W4386877650A5013804346 @default.
- W4386877650 hasAuthorship W4386877650A5031530533 @default.
- W4386877650 hasAuthorship W4386877650A5051158759 @default.
- W4386877650 hasAuthorship W4386877650A5072207899 @default.
- W4386877650 hasAuthorship W4386877650A5086546808 @default.
- W4386877650 hasBestOaLocation W43868776501 @default.
- W4386877650 hasConcept C12554922 @default.
- W4386877650 hasConcept C130316041 @default.
- W4386877650 hasConcept C148785051 @default.
- W4386877650 hasConcept C164866538 @default.
- W4386877650 hasConcept C168240541 @default.
- W4386877650 hasConcept C171250308 @default.
- W4386877650 hasConcept C185592680 @default.
- W4386877650 hasConcept C192562407 @default.
- W4386877650 hasConcept C199360897 @default.
- W4386877650 hasConcept C3018040386 @default.
- W4386877650 hasConcept C41008148 @default.
- W4386877650 hasConcept C41625074 @default.
- W4386877650 hasConcept C55493867 @default.
- W4386877650 hasConcept C83029808 @default.