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- W4386877963 abstract "The combined activity of epigenetic features, which include histone post-translational modifications, DNA methylation, and nucleosome positioning, regulates gene expression independently from changes in the DNA sequence, defining how the shared genetic information of an organism is used to generate different cell phenotypes. Alterations in epigenetic processes have been linked with a multitude of diseases, including cancer, fueling interest in the discovery of drugs targeting the proteins responsible for writing, erasing, or reading histone and DNA modifications. Mass spectrometry (MS)-based proteomics has emerged as a versatile tool that can assist drug discovery pipelines from target validation, through target deconvolution, to monitoring drug efficacy in vivo. Here, we provide an overview of the contributions of MS-based proteomics to epigenetic drug discovery, describing the main approaches that can be used to support different drug discovery pipelines and highlighting how they contributed to the development and characterization of epigenetic drugs." @default.
- W4386877963 created "2023-09-21" @default.
- W4386877963 creator A5059227149 @default.
- W4386877963 creator A5069934756 @default.
- W4386877963 date "2023-09-19" @default.
- W4386877963 modified "2023-09-27" @default.
- W4386877963 title "Proteomics contributions to epigenetic drug discovery" @default.
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