FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386879440> ?p ?o ?g. }

• W4386879440 endingPage "2354" @default.
• W4386879440 startingPage "2354" @default.
• W4386879440 abstract "Tuberculosis (TB) is an infectious disease resulting in millions of deaths annually worldwide. TB treatment is challenging due to a huge number of global latent infections and due to multidrug-resistant forms of TB. Inhaled administration of anti-TB drugs using dry powder inhalers has various advantages over oral administration due to its direct drug delivery and minimization of systemic side effects. Pretomanid (PA-824, PA) is a relatively new drug with potent activity against both active and latent forms of Mycobacterium tuberculosis (Mtb). It is also known for its synergistic effects in combination with pyrazinamide (PYR) and moxifloxacin (MOX). Fixed-dose combination powder formulations of either PYR and PA or PYR and MOX were prepared for inhaled delivery to the deep lung regions where the Mtb habitats were located. Powder formulations were prepared by spray drying using L-leucine as the aerosolization enhancer and were characterized by their particle size, morphology and solid-state properties. In vitro aerosolization behaviour was studied using a Next Generation Impactor, and stability was assessed after storage at room temperature and 30% relative humidity for three months. Spray drying with L-leucine resulted in spherical dimpled particles, 1.9 and 2.4 µm in size for PYR-PA and PYR-MOX combinations, respectively. The powder formulations had an emitted dose of >83% and a fine particle fraction of >65%. PA and MOX showed better stability in the combination powders compared to PYR. Combination powder formulations with high aerosolization efficiency for direct delivery to the lungs were developed in this study for use in the treatment of latent and multidrug-resistant TB infections." @default.
• W4386879440 created "2023-09-21" @default.
• W4386879440 creator A5001201301 @default.
• W4386879440 creator A5018573771 @default.
• W4386879440 creator A5061392978 @default.
• W4386879440 creator A5072403682 @default.
• W4386879440 creator A5086292255 @default.
• W4386879440 date "2023-09-20" @default.
• W4386879440 modified "2023-10-14" @default.
• W4386879440 title "Inhalable Combination Powder Formulations for Treating Latent and Multidrug-Resistant Tuberculosis: Formulation and In Vitro Characterization" @default.
• W4386879440 cites W1968097405 @default.
• W4386879440 cites W1977671952 @default.
• W4386879440 cites W1986106712 @default.
• W4386879440 cites W1993151768 @default.
• W4386879440 cites W2015567288 @default.
• W4386879440 cites W2024307455 @default.
• W4386879440 cites W2029544602 @default.
• W4386879440 cites W2056570578 @default.
• W4386879440 cites W2057212110 @default.
• W4386879440 cites W2061690001 @default.
• W4386879440 cites W2064337758 @default.
• W4386879440 cites W2075287743 @default.
• W4386879440 cites W2095717898 @default.
• W4386879440 cites W2096015848 @default.
• W4386879440 cites W2109725458 @default.
• W4386879440 cites W2115715292 @default.
• W4386879440 cites W2123158511 @default.
• W4386879440 cites W2141559285 @default.
• W4386879440 cites W2147473978 @default.
• W4386879440 cites W2400401679 @default.
• W4386879440 cites W2550569408 @default.
• W4386879440 cites W2793040573 @default.
• W4386879440 cites W2795423931 @default.
• W4386879440 cites W2899885335 @default.
• W4386879440 cites W2911829413 @default.
• W4386879440 cites W2993767414 @default.
• W4386879440 cites W4225142328 @default.
• W4386879440 cites W4229660860 @default.
• W4386879440 cites W4237342534 @default.
• W4386879440 cites W4311426066 @default.
• W4386879440 cites W4361798717 @default.
• W4386879440 cites W4367315925 @default.
• W4386879440 cites W650827506 @default.
• W4386879440 doi "https://doi.org/10.3390/pharmaceutics15092354" @default.
• W4386879440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37765321" @default.
• W4386879440 hasPublicationYear "2023" @default.
• W4386879440 type Work @default.
• W4386879440 citedByCount "0" @default.
• W4386879440 crossrefType "journal-article" @default.
• W4386879440 hasAuthorship W4386879440A5001201301 @default.
• W4386879440 hasAuthorship W4386879440A5018573771 @default.
• W4386879440 hasAuthorship W4386879440A5061392978 @default.
• W4386879440 hasAuthorship W4386879440A5072403682 @default.
• W4386879440 hasAuthorship W4386879440A5086292255 @default.
• W4386879440 hasBestOaLocation W43868794401 @default.
• W4386879440 hasConcept C105702510 @default.
• W4386879440 hasConcept C13965031 @default.
• W4386879440 hasConcept C142724271 @default.
• W4386879440 hasConcept C147789679 @default.
• W4386879440 hasConcept C185592680 @default.
• W4386879440 hasConcept C187530423 @default.
• W4386879440 hasConcept C192562407 @default.
• W4386879440 hasConcept C2776954882 @default.
• W4386879440 hasConcept C2776967927 @default.
• W4386879440 hasConcept C2777975735 @default.
• W4386879440 hasConcept C2779587474 @default.
• W4386879440 hasConcept C2780459521 @default.
• W4386879440 hasConcept C2781069245 @default.
• W4386879440 hasConcept C43617362 @default.
• W4386879440 hasConcept C540271850 @default.
• W4386879440 hasConcept C71924100 @default.
• W4386879440 hasConcept C8138999 @default.
• W4386879440 hasConcept C82085835 @default.
• W4386879440 hasConcept C98274493 @default.
• W4386879440 hasConceptScore W4386879440C105702510 @default.
• W4386879440 hasConceptScore W4386879440C13965031 @default.
• W4386879440 hasConceptScore W4386879440C142724271 @default.
• W4386879440 hasConceptScore W4386879440C147789679 @default.
• W4386879440 hasConceptScore W4386879440C185592680 @default.
• W4386879440 hasConceptScore W4386879440C187530423 @default.
• W4386879440 hasConceptScore W4386879440C192562407 @default.
• W4386879440 hasConceptScore W4386879440C2776954882 @default.
• W4386879440 hasConceptScore W4386879440C2776967927 @default.
• W4386879440 hasConceptScore W4386879440C2777975735 @default.
• W4386879440 hasConceptScore W4386879440C2779587474 @default.
• W4386879440 hasConceptScore W4386879440C2780459521 @default.
• W4386879440 hasConceptScore W4386879440C2781069245 @default.
• W4386879440 hasConceptScore W4386879440C43617362 @default.
• W4386879440 hasConceptScore W4386879440C540271850 @default.
• W4386879440 hasConceptScore W4386879440C71924100 @default.
• W4386879440 hasConceptScore W4386879440C8138999 @default.
• W4386879440 hasConceptScore W4386879440C82085835 @default.
• W4386879440 hasConceptScore W4386879440C98274493 @default.
• W4386879440 hasFunder F4320334749 @default.
• W4386879440 hasIssue "9" @default.
• W4386879440 hasLocation W43868794401 @default.
• W4386879440 hasLocation W43868794402 @default.
• W4386879440 hasOpenAccess W4386879440 @default.

• next