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- W4386879995 abstract "Decellularized porcine small intestinal submucosa (SIS) has shown promising therapeutic efficacy as a functional wound dressing. Nevertheless, its limited anti-oxidative and immunomodulatory capacities have restricted its application for the treatment of complex skin wounds. Herein, epigallocatechin gallate (EGCG), a polyphenolic compound, was employed for the modification of the SIS to overcome such shortcomings. The EGCG-modified SIS (E-SIS) has shown excellent biocompatibility and improved hydrophilicity for cell adhesion. Notably, in vitro studies showed that the E-SIS could effectively alleviate oxidative stress and facilitate the M1-to-M2 phenotype transition of macrophages, thereby creating a favorable immune microenvironment for cell proliferation, migration, collagen synthesis as well as angiogenesis. A full-thickness skin defect model, combined with macrophage depletion, has further confirmed that the E-SIS could accelerate skin wound repair through immunomodulation in vivo. This suggested that the EGCG modification could provide a facile yet effective method to broaden the applications of the SIS for skin wound management." @default.
- W4386879995 created "2023-09-21" @default.
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- W4386879995 date "2023-09-01" @default.
- W4386879995 modified "2023-09-27" @default.
- W4386879995 title "EGCG modified small intestine submucosa promotes wound healing through immunomodulation" @default.
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- W4386879995 doi "https://doi.org/10.1016/j.compositesb.2023.111005" @default.
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