Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386880071> ?p ?o ?g. }
- W4386880071 endingPage "183" @default.
- W4386880071 startingPage "173" @default.
- W4386880071 abstract "Microbial growth emerges from coordinated synthesis of various cellular components from limited resources. In Saccharomyces cerevisiae, cyclic AMP (cAMP)-mediated signaling is shown to orchestrate cellular metabolism; however, it remains unclear quantitatively how the controlling circuit drives resource partition and subsequently shapes biomass growth. Here we combined experiment with mathematical modeling to dissect the signaling-mediated growth optimization of S. cerevisiae. We showed that, through cAMP-mediated control, the organism achieves maximal or nearly maximal steady-state growth during the utilization of multiple tested substrates as well as under perturbations impairing glucose uptake. However, the optimal cAMP concentration varies across cases, suggesting that different modes of resource allocation are adopted for varied conditions. Under settings with nutrient alterations, S. cerevisiae tunes its cAMP level to dynamically reprogram itself to realize rapid adaptation. Moreover, to achieve growth maximization, cells employ additional regulatory systems such as the Gcn2-mediated amino acid control. This study establishes a systematic understanding of global resource allocation in S. cerevisiae, providing insights into quantitative yeast physiology as well as metabolic strain engineering for biotechnological applications." @default.
- W4386880071 created "2023-09-21" @default.
- W4386880071 creator A5014465828 @default.
- W4386880071 creator A5023153444 @default.
- W4386880071 creator A5036229081 @default.
- W4386880071 creator A5040137364 @default.
- W4386880071 creator A5083272185 @default.
- W4386880071 date "2023-11-01" @default.
- W4386880071 modified "2023-10-16" @default.
- W4386880071 title "Controlling circuitry dictates the growth optimization of Saccharomyces cerevisiae" @default.
- W4386880071 cites W1651496407 @default.
- W4386880071 cites W1967210731 @default.
- W4386880071 cites W1971439989 @default.
- W4386880071 cites W1973816983 @default.
- W4386880071 cites W1974605099 @default.
- W4386880071 cites W1976953376 @default.
- W4386880071 cites W1984442538 @default.
- W4386880071 cites W1985161570 @default.
- W4386880071 cites W1996231038 @default.
- W4386880071 cites W2007786225 @default.
- W4386880071 cites W2012665233 @default.
- W4386880071 cites W2027126666 @default.
- W4386880071 cites W2027257502 @default.
- W4386880071 cites W2027592091 @default.
- W4386880071 cites W2033421614 @default.
- W4386880071 cites W2042493870 @default.
- W4386880071 cites W2043537305 @default.
- W4386880071 cites W2044463066 @default.
- W4386880071 cites W2056036930 @default.
- W4386880071 cites W2061659241 @default.
- W4386880071 cites W2088959549 @default.
- W4386880071 cites W2097016419 @default.
- W4386880071 cites W2097909961 @default.
- W4386880071 cites W2104724247 @default.
- W4386880071 cites W2109535551 @default.
- W4386880071 cites W2114641752 @default.
- W4386880071 cites W2115606218 @default.
- W4386880071 cites W2122164513 @default.
- W4386880071 cites W2129151536 @default.
- W4386880071 cites W2130519219 @default.
- W4386880071 cites W2140101799 @default.
- W4386880071 cites W2150904401 @default.
- W4386880071 cites W2152855010 @default.
- W4386880071 cites W2165762336 @default.
- W4386880071 cites W2167348821 @default.
- W4386880071 cites W2168797545 @default.
- W4386880071 cites W2169832274 @default.
- W4386880071 cites W2212431290 @default.
- W4386880071 cites W2300067231 @default.
- W4386880071 cites W2327297891 @default.
- W4386880071 cites W2491691281 @default.
- W4386880071 cites W2539530515 @default.
- W4386880071 cites W2571702114 @default.
- W4386880071 cites W2759254532 @default.
- W4386880071 cites W2762723870 @default.
- W4386880071 cites W2803095132 @default.
- W4386880071 cites W2897377645 @default.
- W4386880071 cites W2898796967 @default.
- W4386880071 cites W2898853230 @default.
- W4386880071 cites W2953251842 @default.
- W4386880071 cites W2982018316 @default.
- W4386880071 cites W3010882806 @default.
- W4386880071 cites W3153157041 @default.
- W4386880071 cites W365193969 @default.
- W4386880071 cites W4243441145 @default.
- W4386880071 doi "https://doi.org/10.1016/j.ymben.2023.09.013" @default.
- W4386880071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37739159" @default.
- W4386880071 hasPublicationYear "2023" @default.
- W4386880071 type Work @default.
- W4386880071 citedByCount "0" @default.
- W4386880071 crossrefType "journal-article" @default.
- W4386880071 hasAuthorship W4386880071A5014465828 @default.
- W4386880071 hasAuthorship W4386880071A5023153444 @default.
- W4386880071 hasAuthorship W4386880071A5036229081 @default.
- W4386880071 hasAuthorship W4386880071A5040137364 @default.
- W4386880071 hasAuthorship W4386880071A5083272185 @default.
- W4386880071 hasConcept C104317684 @default.
- W4386880071 hasConcept C126255220 @default.
- W4386880071 hasConcept C127413603 @default.
- W4386880071 hasConcept C139807058 @default.
- W4386880071 hasConcept C152662350 @default.
- W4386880071 hasConcept C169760540 @default.
- W4386880071 hasConcept C183696295 @default.
- W4386880071 hasConcept C2776330181 @default.
- W4386880071 hasConcept C2777576037 @default.
- W4386880071 hasConcept C2779222958 @default.
- W4386880071 hasConcept C33923547 @default.
- W4386880071 hasConcept C55493867 @default.
- W4386880071 hasConcept C62112901 @default.
- W4386880071 hasConcept C62231903 @default.
- W4386880071 hasConcept C6350086 @default.
- W4386880071 hasConcept C70721500 @default.
- W4386880071 hasConcept C86803240 @default.
- W4386880071 hasConcept C95444343 @default.
- W4386880071 hasConceptScore W4386880071C104317684 @default.
- W4386880071 hasConceptScore W4386880071C126255220 @default.
- W4386880071 hasConceptScore W4386880071C127413603 @default.
- W4386880071 hasConceptScore W4386880071C139807058 @default.