Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386880261> ?p ?o ?g. }
- W4386880261 endingPage "134659" @default.
- W4386880261 startingPage "134659" @default.
- W4386880261 abstract "Point-of-care testing (POCT) devices are currently available for the detection of various important diseases owing to their easy-to-use, portable, and user-friendly nature. However, the multistep regent manipulation still impedes the performance of the device for end-users. To address this issue, we present a novel sequential flow-through microfluidic device that incorporates dual flow behaviors (fast-flow/delayed) into a single device for assessing the risk of cardiovascular disease (CVDs) using C-reactive protein (CRP) as the model analyte. The device features a fast-flow channel for automated washing of unbound CRP antigens and a delayed channel for flow of a redox reagent for electrochemical analysis. It requires only a single buffer loading, resulting in a total analysis time of 15 minutes. To overcome challenges related to storage stability and the affinity of antibodies in the manufacturing process, we integrated the P3-CRP peptide as a new bioreceptor for CRP detection. The performance of both the P3-CRP peptide and antibodies was assessed and examined using chronocoulometry. The proposed device exhibited a limit of detection at 47 pg mL-1 with a wide linear range (5 orders of magnitude). To validate its applicability, the device was tested with serum, plasma, and whole blood samples, yielding satisfactory results." @default.
- W4386880261 created "2023-09-21" @default.
- W4386880261 creator A5021080221 @default.
- W4386880261 creator A5025894781 @default.
- W4386880261 creator A5050000354 @default.
- W4386880261 creator A5060649235 @default.
- W4386880261 creator A5085332833 @default.
- W4386880261 date "2023-12-01" @default.
- W4386880261 modified "2023-10-03" @default.
- W4386880261 title "Point-of-care testing for C-reactive protein in a sequential microfluidic device" @default.
- W4386880261 cites W1200077734 @default.
- W4386880261 cites W2010732987 @default.
- W4386880261 cites W2011886318 @default.
- W4386880261 cites W2048521619 @default.
- W4386880261 cites W2058339176 @default.
- W4386880261 cites W2120255779 @default.
- W4386880261 cites W2125267381 @default.
- W4386880261 cites W2146367394 @default.
- W4386880261 cites W2287597668 @default.
- W4386880261 cites W2569176550 @default.
- W4386880261 cites W2589891587 @default.
- W4386880261 cites W2594148904 @default.
- W4386880261 cites W2598221416 @default.
- W4386880261 cites W2892497090 @default.
- W4386880261 cites W2900905586 @default.
- W4386880261 cites W2901035567 @default.
- W4386880261 cites W2904561537 @default.
- W4386880261 cites W2911757655 @default.
- W4386880261 cites W2912960131 @default.
- W4386880261 cites W2916040600 @default.
- W4386880261 cites W2924010847 @default.
- W4386880261 cites W2954044549 @default.
- W4386880261 cites W2966189985 @default.
- W4386880261 cites W3025160648 @default.
- W4386880261 cites W3047120091 @default.
- W4386880261 cites W3111314177 @default.
- W4386880261 cites W3119978658 @default.
- W4386880261 cites W3125495819 @default.
- W4386880261 cites W3164309747 @default.
- W4386880261 cites W3188023486 @default.
- W4386880261 cites W3189940940 @default.
- W4386880261 cites W3207295956 @default.
- W4386880261 cites W3216170402 @default.
- W4386880261 cites W4225000472 @default.
- W4386880261 cites W4280540390 @default.
- W4386880261 cites W4281613714 @default.
- W4386880261 cites W4282832032 @default.
- W4386880261 cites W4293581944 @default.
- W4386880261 cites W4312082766 @default.
- W4386880261 cites W4313397856 @default.
- W4386880261 cites W4372342806 @default.
- W4386880261 cites W4380730758 @default.
- W4386880261 cites W4386590217 @default.
- W4386880261 doi "https://doi.org/10.1016/j.snb.2023.134659" @default.
- W4386880261 hasPublicationYear "2023" @default.
- W4386880261 type Work @default.
- W4386880261 citedByCount "0" @default.
- W4386880261 crossrefType "journal-article" @default.
- W4386880261 hasAuthorship W4386880261A5021080221 @default.
- W4386880261 hasAuthorship W4386880261A5025894781 @default.
- W4386880261 hasAuthorship W4386880261A5050000354 @default.
- W4386880261 hasAuthorship W4386880261A5060649235 @default.
- W4386880261 hasAuthorship W4386880261A5085332833 @default.
- W4386880261 hasConcept C10349863 @default.
- W4386880261 hasConcept C10390740 @default.
- W4386880261 hasConcept C119128265 @default.
- W4386880261 hasConcept C136229726 @default.
- W4386880261 hasConcept C142724271 @default.
- W4386880261 hasConcept C171250308 @default.
- W4386880261 hasConcept C185592680 @default.
- W4386880261 hasConcept C192562407 @default.
- W4386880261 hasConcept C203014093 @default.
- W4386880261 hasConcept C41008148 @default.
- W4386880261 hasConcept C43617362 @default.
- W4386880261 hasConcept C51915194 @default.
- W4386880261 hasConcept C64841741 @default.
- W4386880261 hasConcept C71924100 @default.
- W4386880261 hasConcept C8673954 @default.
- W4386880261 hasConceptScore W4386880261C10349863 @default.
- W4386880261 hasConceptScore W4386880261C10390740 @default.
- W4386880261 hasConceptScore W4386880261C119128265 @default.
- W4386880261 hasConceptScore W4386880261C136229726 @default.
- W4386880261 hasConceptScore W4386880261C142724271 @default.
- W4386880261 hasConceptScore W4386880261C171250308 @default.
- W4386880261 hasConceptScore W4386880261C185592680 @default.
- W4386880261 hasConceptScore W4386880261C192562407 @default.
- W4386880261 hasConceptScore W4386880261C203014093 @default.
- W4386880261 hasConceptScore W4386880261C41008148 @default.
- W4386880261 hasConceptScore W4386880261C43617362 @default.
- W4386880261 hasConceptScore W4386880261C51915194 @default.
- W4386880261 hasConceptScore W4386880261C64841741 @default.
- W4386880261 hasConceptScore W4386880261C71924100 @default.
- W4386880261 hasConceptScore W4386880261C8673954 @default.
- W4386880261 hasFunder F4320320305 @default.
- W4386880261 hasFunder F4320322511 @default.
- W4386880261 hasFunder F4320335039 @default.
- W4386880261 hasFunder F4320335197 @default.
- W4386880261 hasLocation W43868802611 @default.