FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386880296> ?p ?o ?g. }

• W4386880296 endingPage "117201" @default.
• W4386880296 startingPage "117201" @default.
• W4386880296 abstract "Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. It was mainly applied to inhibit the decrease of ovarian reserve function in patients. However, the anti-apoptosis mechanism of BTR remains unknown. Aim of the study: The formula of BTR is composed of prepared rehmannia root, debark peony root, carapax testudinis and asiatic cornelian cherry fruit. All four components contain the essences of nourishing yin and tonic-kidney. In the theory of TCM, the kidneys store the essence and are primarily responsible for reproduction and development. Hence, we speculated that BTR had some effect on women's reproductive system. In our research, rat serum contains BTR resolved into culture medium for incubation with miR-23a-induced KGN cells to test and determine our hypothesis. BTR was prepared by the traditional decoction method to collect concentrated liquids for oral administration to rats (15.00g/kg) for 14 days. The group with miR-23a-induced KGN cells was selected as the positive control, while the mimic one was the control. Pro-apoptosis and anti-apoptosis biomarkers were detected and analyzed by western blot together with upstream transcription factors and intracellular apoptotic signal pathways. The medium- and high-concentration of BRT greatly reduced the apoptosis of miR-23a-induced KGN cells both in mitochondria and cytoplasm. It showed the up-regulation of SIRT1 and SIRT3, the down-regulation of pro-apoptosis factor Bax and apoptotic-related proteins Caspase 3, 8, 9, and the reduction of phosphorylation of ERK1/2 and NF-κB. however, there was no consistency in the group with a low concentration of BTR, compared with those of other groups. Our research verified that BTR had a positive effect on women's reproductive system under medium or high concentration, illuminated the intrinsic mechanism at molecular levels, and convinced its potential application values in clinical settings." @default.
• W4386880296 created "2023-09-21" @default.
• W4386880296 creator A5011496755 @default.
• W4386880296 creator A5030741188 @default.
• W4386880296 creator A5032423839 @default.
• W4386880296 creator A5048758517 @default.
• W4386880296 creator A5049056826 @default.
• W4386880296 creator A5078573176 @default.
• W4386880296 date "2023-09-01" @default.
• W4386880296 modified "2023-09-29" @default.
• W4386880296 title "Bushen Tianjing Recipe inhibits human ovarian granulosa cell line KGN apoptosis induced by miR-23a through the regulation of the sirtuin family" @default.
• W4386880296 cites W1531691583 @default.
• W4386880296 cites W1904882776 @default.
• W4386880296 cites W1976477577 @default.
• W4386880296 cites W1979504051 @default.
• W4386880296 cites W1996180136 @default.
• W4386880296 cites W2002696989 @default.
• W4386880296 cites W2002919668 @default.
• W4386880296 cites W2007625194 @default.
• W4386880296 cites W2027139882 @default.
• W4386880296 cites W2042555287 @default.
• W4386880296 cites W2048005838 @default.
• W4386880296 cites W2066571367 @default.
• W4386880296 cites W2119240817 @default.
• W4386880296 cites W2126880501 @default.
• W4386880296 cites W2134198398 @default.
• W4386880296 cites W2142842345 @default.
• W4386880296 cites W2160627493 @default.
• W4386880296 cites W2178316435 @default.
• W4386880296 cites W2282509758 @default.
• W4386880296 cites W2289310757 @default.
• W4386880296 cites W2300485463 @default.
• W4386880296 cites W2473522482 @default.
• W4386880296 cites W2498953911 @default.
• W4386880296 cites W2563775745 @default.
• W4386880296 cites W2609663069 @default.
• W4386880296 cites W2610114548 @default.
• W4386880296 cites W2768957179 @default.
• W4386880296 cites W2790630451 @default.
• W4386880296 cites W2899158325 @default.
• W4386880296 cites W2901177291 @default.
• W4386880296 cites W2912444667 @default.
• W4386880296 cites W2939242478 @default.
• W4386880296 cites W2981996329 @default.
• W4386880296 cites W2982863864 @default.
• W4386880296 cites W2997373879 @default.
• W4386880296 cites W3022064211 @default.
• W4386880296 cites W3036759197 @default.
• W4386880296 cites W3099479907 @default.
• W4386880296 cites W4200317737 @default.
• W4386880296 cites W4210818413 @default.
• W4386880296 cites W4248331815 @default.
• W4386880296 cites W4307846934 @default.
• W4386880296 doi "https://doi.org/10.1016/j.jep.2023.117201" @default.
• W4386880296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37739102" @default.
• W4386880296 hasPublicationYear "2023" @default.
• W4386880296 type Work @default.
• W4386880296 citedByCount "0" @default.
• W4386880296 crossrefType "journal-article" @default.
• W4386880296 hasAuthorship W4386880296A5011496755 @default.
• W4386880296 hasAuthorship W4386880296A5030741188 @default.
• W4386880296 hasAuthorship W4386880296A5032423839 @default.
• W4386880296 hasAuthorship W4386880296A5048758517 @default.
• W4386880296 hasAuthorship W4386880296A5049056826 @default.
• W4386880296 hasAuthorship W4386880296A5078573176 @default.
• W4386880296 hasConcept C104317684 @default.
• W4386880296 hasConcept C142724271 @default.
• W4386880296 hasConcept C185592680 @default.
• W4386880296 hasConcept C188947578 @default.
• W4386880296 hasConcept C190283241 @default.
• W4386880296 hasConcept C204787440 @default.
• W4386880296 hasConcept C2776415932 @default.
• W4386880296 hasConcept C502942594 @default.
• W4386880296 hasConcept C55493867 @default.
• W4386880296 hasConcept C556039675 @default.
• W4386880296 hasConcept C71924100 @default.
• W4386880296 hasConcept C79879829 @default.
• W4386880296 hasConcept C86803240 @default.
• W4386880296 hasConcept C95444343 @default.
• W4386880296 hasConcept C98274493 @default.
• W4386880296 hasConceptScore W4386880296C104317684 @default.
• W4386880296 hasConceptScore W4386880296C142724271 @default.
• W4386880296 hasConceptScore W4386880296C185592680 @default.
• W4386880296 hasConceptScore W4386880296C188947578 @default.
• W4386880296 hasConceptScore W4386880296C190283241 @default.
• W4386880296 hasConceptScore W4386880296C204787440 @default.
• W4386880296 hasConceptScore W4386880296C2776415932 @default.
• W4386880296 hasConceptScore W4386880296C502942594 @default.
• W4386880296 hasConceptScore W4386880296C55493867 @default.
• W4386880296 hasConceptScore W4386880296C556039675 @default.
• W4386880296 hasConceptScore W4386880296C71924100 @default.
• W4386880296 hasConceptScore W4386880296C79879829 @default.
• W4386880296 hasConceptScore W4386880296C86803240 @default.
• W4386880296 hasConceptScore W4386880296C95444343 @default.
• W4386880296 hasConceptScore W4386880296C98274493 @default.
• W4386880296 hasLocation W43868802961 @default.
• W4386880296 hasLocation W43868802962 @default.
• W4386880296 hasOpenAccess W4386880296 @default.

• next