FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386880451> ?p ?o ?g. }

• W4386880451 abstract "Abstract Background: Osteoarthritis (OA) is the most common joint disorder characterized by cartilage degradation and abnormal subchondral bone remodeling. As a post-translational modification, small ubiquitin-like modifiers (SUMOs) are involved in the pathogenesis of many diseases including arthritis. However, their role in OA remains to be elucidated. Furthermore, although salubrinal is reported to inhibit bone resorption and stimulate bone formation in osteoporosis, its effect on OA is not well understood. Methods: To elucidate the role of salubrinal in OA and any linkage to SUMOylation, 54 mice were employed in 3 randomly assigned groups (n = 18), including the sham control (control), osteoarthritis (OA), and salubrinal-treated OA (OAS). OA was induced by transecting the medial collateral ligament and removing the medial meniscus. Salubrinal was administered subcutaneously at a dose of 2mg/kg daily for 2 weeks. Results: Salubrinal reduced the osteoclast surface and elevated the osteoblast number in the trabecular subchondral bone. It also suppressed osteoclast activities and promoted osteoblast differentiation from bone marrow-derived cells. HE staining and CT imaging revealed that salubrinal improved the microstructure of the subchondral bone, and it reduced OARSI scores and CC/TAC. Silencing SUMO1 attenuated salubrinal’s beneficial effects on osteoclastogenesis and osteoblastogenesis. Conclusions: Salubrinal improved the abnormal remodeling of the subchondral bone in OA, and its beneficial effects were partly mediated by SUMO1." @default.
• W4386880451 created "2023-09-21" @default.
• W4386880451 creator A5012996517 @default.
• W4386880451 creator A5038218094 @default.
• W4386880451 creator A5055151897 @default.
• W4386880451 creator A5062607928 @default.
• W4386880451 creator A5081940051 @default.
• W4386880451 creator A5085352453 @default.
• W4386880451 creator A5088358780 @default.
• W4386880451 date "2023-09-21" @default.
• W4386880451 modified "2023-09-27" @default.
• W4386880451 title "SUMO1 mediated salubrinal-treated the abnormal remodeling of the subchondral bone in osteoarthritis" @default.
• W4386880451 cites W1915697590 @default.
• W4386880451 cites W1996062288 @default.
• W4386880451 cites W2013791944 @default.
• W4386880451 cites W2072016997 @default.
• W4386880451 cites W2089948557 @default.
• W4386880451 cites W2099427592 @default.
• W4386880451 cites W2165305672 @default.
• W4386880451 cites W2339409279 @default.
• W4386880451 cites W2516114610 @default.
• W4386880451 cites W2522694580 @default.
• W4386880451 cites W2528785634 @default.
• W4386880451 cites W2564071409 @default.
• W4386880451 cites W2724354611 @default.
• W4386880451 cites W2893957179 @default.
• W4386880451 cites W2902798493 @default.
• W4386880451 cites W2905584010 @default.
• W4386880451 cites W2909236537 @default.
• W4386880451 cites W2915567854 @default.
• W4386880451 cites W2920832988 @default.
• W4386880451 cites W2940701515 @default.
• W4386880451 cites W2943925354 @default.
• W4386880451 cites W2953548789 @default.
• W4386880451 cites W2994125455 @default.
• W4386880451 cites W2999654231 @default.
• W4386880451 cites W3011043164 @default.
• W4386880451 cites W3032930264 @default.
• W4386880451 cites W3043639762 @default.
• W4386880451 cites W3084066799 @default.
• W4386880451 cites W3087396810 @default.
• W4386880451 cites W3094449489 @default.
• W4386880451 cites W3096429227 @default.
• W4386880451 cites W3124473689 @default.
• W4386880451 cites W3137108207 @default.
• W4386880451 cites W3137434202 @default.
• W4386880451 cites W3193211875 @default.
• W4386880451 cites W4214750277 @default.
• W4386880451 cites W4294126216 @default.
• W4386880451 cites W4294343865 @default.
• W4386880451 cites W4313656929 @default.
• W4386880451 doi "https://doi.org/10.21203/rs.3.rs-3315593/v1" @default.
• W4386880451 hasPublicationYear "2023" @default.
• W4386880451 type Work @default.
• W4386880451 citedByCount "0" @default.
• W4386880451 crossrefType "posted-content" @default.
• W4386880451 hasAuthorship W4386880451A5012996517 @default.
• W4386880451 hasAuthorship W4386880451A5038218094 @default.
• W4386880451 hasAuthorship W4386880451A5055151897 @default.
• W4386880451 hasAuthorship W4386880451A5062607928 @default.
• W4386880451 hasAuthorship W4386880451A5081940051 @default.
• W4386880451 hasAuthorship W4386880451A5085352453 @default.
• W4386880451 hasAuthorship W4386880451A5088358780 @default.
• W4386880451 hasBestOaLocation W43868804511 @default.
• W4386880451 hasConcept C105702510 @default.
• W4386880451 hasConcept C126322002 @default.
• W4386880451 hasConcept C142724271 @default.
• W4386880451 hasConcept C170033053 @default.
• W4386880451 hasConcept C170493617 @default.
• W4386880451 hasConcept C185592680 @default.
• W4386880451 hasConcept C202751555 @default.
• W4386880451 hasConcept C204787440 @default.
• W4386880451 hasConcept C2776033226 @default.
• W4386880451 hasConcept C2776164576 @default.
• W4386880451 hasConcept C2776541429 @default.
• W4386880451 hasConcept C2778260815 @default.
• W4386880451 hasConcept C502942594 @default.
• W4386880451 hasConcept C55493867 @default.
• W4386880451 hasConcept C673006 @default.
• W4386880451 hasConcept C71924100 @default.
• W4386880451 hasConcept C8337478 @default.
• W4386880451 hasConceptScore W4386880451C105702510 @default.
• W4386880451 hasConceptScore W4386880451C126322002 @default.
• W4386880451 hasConceptScore W4386880451C142724271 @default.
• W4386880451 hasConceptScore W4386880451C170033053 @default.
• W4386880451 hasConceptScore W4386880451C170493617 @default.
• W4386880451 hasConceptScore W4386880451C185592680 @default.
• W4386880451 hasConceptScore W4386880451C202751555 @default.
• W4386880451 hasConceptScore W4386880451C204787440 @default.
• W4386880451 hasConceptScore W4386880451C2776033226 @default.
• W4386880451 hasConceptScore W4386880451C2776164576 @default.
• W4386880451 hasConceptScore W4386880451C2776541429 @default.
• W4386880451 hasConceptScore W4386880451C2778260815 @default.
• W4386880451 hasConceptScore W4386880451C502942594 @default.
• W4386880451 hasConceptScore W4386880451C55493867 @default.
• W4386880451 hasConceptScore W4386880451C673006 @default.
• W4386880451 hasConceptScore W4386880451C71924100 @default.
• W4386880451 hasConceptScore W4386880451C8337478 @default.
• W4386880451 hasLocation W43868804511 @default.
• W4386880451 hasOpenAccess W4386880451 @default.

• next