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• W4386880690 abstract "Purpose To evaluate the incidence of new retinal artery occlusion (RAO) and retinal vein occlusion (RVO) after the diagnosis of coronavirus disease 2019 (COVID-19) or vaccination against COVID-19 and compare the incidences with the population with neither. Design Nationwide population-based cohort study Participants We categorized 8,418,590 patients from a nationwide population-based cohort into control, COVID-19 infection, and COVID-19 vaccination groups. Methods We calculated the cumulative incidence of RAO and RVO in Groups 1 (controls), 2 (infection), and 3 (vaccination) using the Kaplan–Meier method. We calculated hazard ratios and 95% confidence intervals (CIs) based on the Poisson distribution for RAO and RVO according to each group and subgroup using Cox proportional hazards models, with Group 1 as the reference. We conducted univariate and multivariate analyses for the risk factors of RAO and RVO according to each subgroup. Main outcome measures Cumulative incidence and risks of incidence of RAO and RVO from the index date to day 60. Results In multivariable analysis, there was no significant increase in RAO and RVO risks after COVID-19 or COVID-19 vaccination in both men and women. These results were consistently observed across various conditions in sensitivity analyses. In subgroup analysis, individuals who were vaccinated before infection showed no significant increase in RAO and RVO risks in both sexes compared with the control group. In the subgroup analysis of vaccinated patients, the hazard ratios of RAO and RVO for different vaccine types did not show an increase compared with the control group; however, an exception was observed in women who received mRNA-1273 vaccines, who showed a higher RAO hazard ratio (4.65, 95% CI 1.27–17.03, p = 0.021). Conclusions RAO and RVO rarely occurred within 60 days of COVID-19 diagnosis or vaccination. We observed no increase in the hazard ratio of RVO and RAO relative to COVID-19 or COVID-19 vaccination except for a possible increase in the RAO hazard ratio in women who received mRNA-1273, for which the raw incidence was extremely low. Further investigation is required to validate this result." @default.
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• W4386880690 date "2023-09-01" @default.
• W4386880690 modified "2023-10-15" @default.
• W4386880690 title "Retinal artery and vein occlusion risks after COVID-19 or COVID-19 vaccination" @default.
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• W4386880690 doi "https://doi.org/10.1016/j.ophtha.2023.09.019" @default.
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