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- W4386880937 abstract "Abstract Background Several adipokines are involved in the pathophysiology of gestational diabetes mellitus (GDM), we explored potential associations of the variant + 45T/G (rs2241766) in ADIPOQ gene with maternal circulating adiponectin, obesity and GDM risk in apparently healthy and GDM Iraqi pregnant women. Methods Participants including 50 normal pregnant women and 52 pregnant women with GDM were enrolled from December 2022 to May 2023 at Baghdad Teaching Hospital, Medical city. Serum adiponectin levels were measured by immunoassay. ADIPOQ + 45T/G (rs2241766) variant was determined through Taqman Real Time quantitative polymerase chain reaction RT-PCR technique. Results ADIPOQ + 45T/G polymorphism was significantly associated with an increased risk of GDM. The G allele frequency of ADIPOQ + 45T/G was significantly higher among GDM compared with non-GDM controls (odds ratio [OR]: 3.5; 95% confidence interval [CI]: 1.8931 to 6.6466; P = 0.0004). Serum adiponectin concentration was also significantly decreased among the GDM who had a BMI of less than 30 kg/m 2 . Conclusion This study revealed that ADIPOQ + 45T/G rs2241766 polymorphism was implicated in GDM onset. In our study, serum adiponectin levels were significantly lower in Iraqi pregnant women with GDM who had pregnancy BMI of < 25 Kg/m 2 . However, to elucidate the mechanism of adiponectin in predicting gestational diabetes mellitus, further studies are required." @default.
- W4386880937 created "2023-09-21" @default.
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- W4386880937 date "2023-09-20" @default.
- W4386880937 modified "2023-09-27" @default.
- W4386880937 title "Association of ADIPOQ Gene Polymorphism with Circulating Adiponectin Level in Iraqi Women with Gestational Diabetes Mellitus" @default.
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- W4386880937 doi "https://doi.org/10.21203/rs.3.rs-3367444/v1" @default.
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