FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386884059> ?p ?o ?g. }

• W4386884059 abstract "Vibrio cholerae, the causative agent of the disease cholera, is responsible for multiple pandemics. V. cholerae binds to and colonizes the gastrointestinal tract within the human host, as well as various surfaces in the marine environment (e.g., zooplankton) during interepidemic periods. A large adhesin, the Flagellar Regulated Hemagglutinin A (FrhA), enhances binding to erythrocytes and epithelial cells and enhances intestinal colonization. We identified a peptide-binding domain (PBD) within FrhA that mediates hemagglutination, binding to epithelial cells, intestinal colonization, and facilitates biofilm formation. Intriguingly, this domain is also found in the ice-binding protein of the Antarctic bacterium Marinomonas primoryensis, where it mediates binding to diatoms. Peptide inhibitors of the M. primoryensis PBD inhibit V. cholerae binding to human cells as well as to diatoms and inhibit biofilm formation. Moreover, the M. primoryensis PBD inserted into FrhA allows V. cholerae to bind human cells and colonize the intestine and also enhances biofilm formation, demonstrating the interchangeability of the PBD from these bacteria. Importantly, peptide inhibitors of PBD reduce V. cholerae intestinal colonization in infant mice. These studies demonstrate how V. cholerae uses a PBD shared with a diatom-binding Antarctic bacterium to facilitate intestinal colonization in humans and biofilm formation in the environment." @default.
• W4386884059 created "2023-09-21" @default.
• W4386884059 creator A5019709779 @default.
• W4386884059 creator A5021320199 @default.
• W4386884059 creator A5033454157 @default.
• W4386884059 creator A5035023245 @default.
• W4386884059 creator A5035806263 @default.
• W4386884059 creator A5043264934 @default.
• W4386884059 creator A5053019225 @default.
• W4386884059 creator A5064110980 @default.
• W4386884059 creator A5067632981 @default.
• W4386884059 creator A5072020285 @default.
• W4386884059 date "2023-09-20" @default.
• W4386884059 modified "2023-10-12" @default.
• W4386884059 title "A peptide-binding domain shared with an Antarctic bacterium facilitates <i>Vibrio cholerae</i> human cell binding and intestinal colonization" @default.
• W4386884059 cites W1249345904 @default.
• W4386884059 cites W164398759 @default.
• W4386884059 cites W1803102843 @default.
• W4386884059 cites W1835112155 @default.
• W4386884059 cites W1930575920 @default.
• W4386884059 cites W1970057259 @default.
• W4386884059 cites W1971008206 @default.
• W4386884059 cites W1977151336 @default.
• W4386884059 cites W1984699600 @default.
• W4386884059 cites W1991373417 @default.
• W4386884059 cites W2005919188 @default.
• W4386884059 cites W2005962419 @default.
• W4386884059 cites W2008821578 @default.
• W4386884059 cites W2011772176 @default.
• W4386884059 cites W2014834088 @default.
• W4386884059 cites W2038718832 @default.
• W4386884059 cites W2052618033 @default.
• W4386884059 cites W2063034589 @default.
• W4386884059 cites W2080001285 @default.
• W4386884059 cites W2092573564 @default.
• W4386884059 cites W2096525273 @default.
• W4386884059 cites W2097764988 @default.
• W4386884059 cites W2128879347 @default.
• W4386884059 cites W2130380516 @default.
• W4386884059 cites W2137871890 @default.
• W4386884059 cites W2138687527 @default.
• W4386884059 cites W2139543196 @default.
• W4386884059 cites W2142941796 @default.
• W4386884059 cites W2144528883 @default.
• W4386884059 cites W2148915230 @default.
• W4386884059 cites W2165129278 @default.
• W4386884059 cites W2742643337 @default.
• W4386884059 cites W2774178591 @default.
• W4386884059 cites W2790549124 @default.
• W4386884059 cites W2792963933 @default.
• W4386884059 cites W2909391765 @default.
• W4386884059 cites W2942903474 @default.
• W4386884059 cites W2965265953 @default.
• W4386884059 cites W2971788024 @default.
• W4386884059 cites W2993738406 @default.
• W4386884059 cites W3110720824 @default.
• W4386884059 cites W3123502856 @default.
• W4386884059 cites W3127713179 @default.
• W4386884059 cites W3177828909 @default.
• W4386884059 cites W3214520753 @default.
• W4386884059 cites W4205440119 @default.
• W4386884059 cites W4289274885 @default.
• W4386884059 doi "https://doi.org/10.1073/pnas.2308238120" @default.
• W4386884059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37729203" @default.
• W4386884059 hasPublicationYear "2023" @default.
• W4386884059 type Work @default.
• W4386884059 citedByCount "0" @default.
• W4386884059 crossrefType "journal-article" @default.
• W4386884059 hasAuthorship W4386884059A5019709779 @default.
• W4386884059 hasAuthorship W4386884059A5021320199 @default.
• W4386884059 hasAuthorship W4386884059A5033454157 @default.
• W4386884059 hasAuthorship W4386884059A5035023245 @default.
• W4386884059 hasAuthorship W4386884059A5035806263 @default.
• W4386884059 hasAuthorship W4386884059A5043264934 @default.
• W4386884059 hasAuthorship W4386884059A5053019225 @default.
• W4386884059 hasAuthorship W4386884059A5064110980 @default.
• W4386884059 hasAuthorship W4386884059A5067632981 @default.
• W4386884059 hasAuthorship W4386884059A5072020285 @default.
• W4386884059 hasBestOaLocation W43868840591 @default.
• W4386884059 hasConcept C104317684 @default.
• W4386884059 hasConcept C179470777 @default.
• W4386884059 hasConcept C2776927270 @default.
• W4386884059 hasConcept C2778643871 @default.
• W4386884059 hasConcept C2778692840 @default.
• W4386884059 hasConcept C51639874 @default.
• W4386884059 hasConcept C523546767 @default.
• W4386884059 hasConcept C54355233 @default.
• W4386884059 hasConcept C547475151 @default.
• W4386884059 hasConcept C55493867 @default.
• W4386884059 hasConcept C58123911 @default.
• W4386884059 hasConcept C86803240 @default.
• W4386884059 hasConcept C89423630 @default.
• W4386884059 hasConcept C95444343 @default.
• W4386884059 hasConceptScore W4386884059C104317684 @default.
• W4386884059 hasConceptScore W4386884059C179470777 @default.
• W4386884059 hasConceptScore W4386884059C2776927270 @default.
• W4386884059 hasConceptScore W4386884059C2778643871 @default.
• W4386884059 hasConceptScore W4386884059C2778692840 @default.
• W4386884059 hasConceptScore W4386884059C51639874 @default.
• W4386884059 hasConceptScore W4386884059C523546767 @default.

• next