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- W4386885105 abstract "It is unclear how the immune system initiates effective tissue repair responses without also simultaneously activating adaptive immune responses to self-antigens released by damaged or necrotic cells. We studied the role of repetitive adrenergic mediated stress on cardiac injury wild-type and programmed death-1–deficient (PD-1−/−) mice treated with 3 intraperitoneal low doses of isoprotenerol followed by an intraperitoneal injection of high-dose ISO 7 days later (ISOprimed/ISOinjury). Repetitive adrenergic stress in ISOprimed/ISOinjury PD-1−/− mice resulted in a persistent dysregulated myocardial inflammatory response characterized by the expansion of autoreactive effector CD8+ T cells, increased cardiac hypertrophy, mild left ventricular dysfunction, and increased lethality when compared with ISOprimed/ISOinjury wild-type mice." @default.
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- W4386885105 date "2023-09-01" @default.
- W4386885105 modified "2023-09-27" @default.
- W4386885105 title "Recurrent Adrenergic Stress Provokes Persistent Myocarditis in PD-1-Deficient Mice" @default.
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- W4386885105 doi "https://doi.org/10.1016/j.jacbts.2023.07.012" @default.
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