Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386886265> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4386886265 abstract "<h3>Background/Aims</h3> Proton pump inhibitors (PPIs) are frequently prescribed to cirrhotic patients, but there is limited longitudinal evidence regarding their effects. This study aimed to assess the impact of PPIs on adverse events in cirrhotic patients. <h3>Methods</h3> A comprehensive search was conducted using the Medline and Embase databases to identify relevant articles. Pooled hazard ratios (HRs) using DerSimonian and Laird random-effects model were calculated to evaluate the risk of adverse events such as long-term mortality, hepatic decompensation, hepatic encephalopathy (HE), spontaneous bacterial peritonitis (SBP), and overall infection in cirrhotic patients with PPI use. <h3>Results</h3> The analysis included 28 studies with 260,854 cirrhotic patients. The prevalence of PPI use among cirrhotic patients was 55.93%. The use of PPIs was not significantly associated with short-term mortality in cirrhotic patients. However, long-term mortality (HR: 1.321, 95% CI: 1.103–1.581, P=0.002), decompensation (HR: 1.646, 95% CI: 1.477–1.835, P<0.001), HE (HR: 1.968, 95% CI: 1.372–2.822, P<0.001), SBP (HR:1.751, 95% CI 1.649–1.859, P<0.001), and infection (HR: 1.370, 95% CI: 1.148–1.634, P<0.001) were significantly associated with PPI use. Sensitivity analysis with prospective studies yielded similar results. <h3>Conclusion</h3> PPIs should be reserved for appropriate indications at lowest effective dose for cirrhotic patients due to the potential harm." @default.
- W4386886265 created "2023-09-21" @default.
- W4386886265 creator A5000540268 @default.
- W4386886265 creator A5009193858 @default.
- W4386886265 creator A5015041967 @default.
- W4386886265 creator A5015449468 @default.
- W4386886265 creator A5016076247 @default.
- W4386886265 creator A5033651099 @default.
- W4386886265 creator A5033842737 @default.
- W4386886265 creator A5043678456 @default.
- W4386886265 creator A5043846829 @default.
- W4386886265 creator A5045471731 @default.
- W4386886265 creator A5049036462 @default.
- W4386886265 creator A5055368865 @default.
- W4386886265 creator A5058087480 @default.
- W4386886265 creator A5064166678 @default.
- W4386886265 creator A5067603783 @default.
- W4386886265 creator A5074144199 @default.
- W4386886265 creator A5075321237 @default.
- W4386886265 creator A5077629563 @default.
- W4386886265 creator A5078445610 @default.
- W4386886265 creator A5092907833 @default.
- W4386886265 date "2023-09-01" @default.
- W4386886265 modified "2023-09-27" @default.
- W4386886265 title "P57 Proton pump inhibitors increases longitudinal risk of mortality, decompensation and infection in cirrhosis: a meta analysis" @default.
- W4386886265 doi "https://doi.org/10.1136/gutjnl-2023-basl.73" @default.
- W4386886265 hasPublicationYear "2023" @default.
- W4386886265 type Work @default.
- W4386886265 citedByCount "0" @default.
- W4386886265 crossrefType "proceedings-article" @default.
- W4386886265 hasAuthorship W4386886265A5000540268 @default.
- W4386886265 hasAuthorship W4386886265A5009193858 @default.
- W4386886265 hasAuthorship W4386886265A5015041967 @default.
- W4386886265 hasAuthorship W4386886265A5015449468 @default.
- W4386886265 hasAuthorship W4386886265A5016076247 @default.
- W4386886265 hasAuthorship W4386886265A5033651099 @default.
- W4386886265 hasAuthorship W4386886265A5033842737 @default.
- W4386886265 hasAuthorship W4386886265A5043678456 @default.
- W4386886265 hasAuthorship W4386886265A5043846829 @default.
- W4386886265 hasAuthorship W4386886265A5045471731 @default.
- W4386886265 hasAuthorship W4386886265A5049036462 @default.
- W4386886265 hasAuthorship W4386886265A5055368865 @default.
- W4386886265 hasAuthorship W4386886265A5058087480 @default.
- W4386886265 hasAuthorship W4386886265A5064166678 @default.
- W4386886265 hasAuthorship W4386886265A5067603783 @default.
- W4386886265 hasAuthorship W4386886265A5074144199 @default.
- W4386886265 hasAuthorship W4386886265A5075321237 @default.
- W4386886265 hasAuthorship W4386886265A5077629563 @default.
- W4386886265 hasAuthorship W4386886265A5078445610 @default.
- W4386886265 hasAuthorship W4386886265A5092907833 @default.
- W4386886265 hasConcept C126322002 @default.
- W4386886265 hasConcept C197934379 @default.
- W4386886265 hasConcept C207103383 @default.
- W4386886265 hasConcept C2777214474 @default.
- W4386886265 hasConcept C2777364826 @default.
- W4386886265 hasConcept C2778721985 @default.
- W4386886265 hasConcept C2780325230 @default.
- W4386886265 hasConcept C44249647 @default.
- W4386886265 hasConcept C71924100 @default.
- W4386886265 hasConcept C90924648 @default.
- W4386886265 hasConcept C95190672 @default.
- W4386886265 hasConceptScore W4386886265C126322002 @default.
- W4386886265 hasConceptScore W4386886265C197934379 @default.
- W4386886265 hasConceptScore W4386886265C207103383 @default.
- W4386886265 hasConceptScore W4386886265C2777214474 @default.
- W4386886265 hasConceptScore W4386886265C2777364826 @default.
- W4386886265 hasConceptScore W4386886265C2778721985 @default.
- W4386886265 hasConceptScore W4386886265C2780325230 @default.
- W4386886265 hasConceptScore W4386886265C44249647 @default.
- W4386886265 hasConceptScore W4386886265C71924100 @default.
- W4386886265 hasConceptScore W4386886265C90924648 @default.
- W4386886265 hasConceptScore W4386886265C95190672 @default.
- W4386886265 hasLocation W43868862651 @default.
- W4386886265 hasOpenAccess W4386886265 @default.
- W4386886265 hasPrimaryLocation W43868862651 @default.
- W4386886265 hasRelatedWork W13668571 @default.
- W4386886265 hasRelatedWork W156267672 @default.
- W4386886265 hasRelatedWork W1983534699 @default.
- W4386886265 hasRelatedWork W2320586028 @default.
- W4386886265 hasRelatedWork W2379893296 @default.
- W4386886265 hasRelatedWork W2392950474 @default.
- W4386886265 hasRelatedWork W2737137833 @default.
- W4386886265 hasRelatedWork W2957174061 @default.
- W4386886265 hasRelatedWork W3157388465 @default.
- W4386886265 hasRelatedWork W4225123154 @default.
- W4386886265 isParatext "false" @default.
- W4386886265 isRetracted "false" @default.
- W4386886265 workType "article" @default.