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• W4386886463 abstract "<h3>Background</h3> Physical frailty is associated with increased mortality in patients with end-stage liver disease (ESLD). Even though physical activity (PA) is recommended in ESLD, a lack of understanding of habitual patterns of PA (especially volume, intensity) and their relationship with physical frailty, limits healthcare professionals to generic NHS guidelines when prescribing PA for patients with ESLD. This prospective observational case-control study aimed to determine the association between physical frailty and the volume and intensity of PA in ESLD. <h3>Method</h3> Patients with ESLD were recruited from the liver transplant waiting list outpatient clinic (Birmingham, UK). Participants wore a GENEActiv® accelerometer watch device on their non-dominant wrist 24hrs/day for up to 14 days at home prior to the study visit. Patient characteristics (i.e. sex, age, disease type and severity) and the liver frailty index (LFI) were collated. The accelerometer data were analysed using R-package, GGIR (version 2.5–0). Average acceleration (PA volume), intensity gradient (spread of intensity participation over 24hrs) and minimum intensity for most active continuous time periods were calculated and compared across four quartiles of the LFI (1st ‘least frail’= <3.37, 2nd = 3.38–3.78, 3rd = 3.79–4.28, 4th ‘most frail’= >4.28). <h3>Results</h3> 43 participants with ESLD (65% male, mean age 54, UKELD 52, 51% ArLD, median LFI 3.59 [3.3–3.6]) were recruited. The volume of PA decreased as the degree of frailty increased, although this did not reach significance (p=0.08) (figure 1A). The intensity of PA significantly decreased as frailty increased (p=0.002), with the least frail achieving PA at significantly higher intensities than the most frail (mean difference 0.40, 95% CI 0.13 to 0.67, p= 0.004) (figure 1B). Those who were least frail were vigorously active for one continuous minute, while the most frail were only moderately active for one continuous minute. Participants with ESLD did not participate in moderate intensity PA for longer than two continuous minutes. <h3>Conclusion</h3> The intensity, rather than volume, of PA has the greatest association with the level of physical frailty in ESLD. Simple patient messages such as ‘when you move, move with intensity’ may be enough to improve physical frailty for patients with ESLD. Furthermore, consideration of short bursts (i.e. 2mins) of moderate intensity PA should be considered feasible in future protocols of PA for patients with ESLD." @default.
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• W4386886463 date "2023-09-01" @default.
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• W4386886463 title "O14 Intensity, rather than volume, of physical activity has the greatest association with physical frailty in end-stage liver disease: a prospective observational study" @default.
• W4386886463 doi "https://doi.org/10.1136/gutjnl-2023-basl.14" @default.
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