Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386886751> ?p ?o ?g. }
- W4386886751 endingPage "232" @default.
- W4386886751 startingPage "217" @default.
- W4386886751 abstract "Enhanced levels of acetic acid reduce the activity of yeast strains employed for industrial fermentation-based applications. Therefore, unraveling the genetic factors underlying the regulation of the tolerance and sensitivity of yeast towards acetic acid is imperative for optimising various industrial processes. In this communication, we have attempted to decipher the acetic acid stress response of the previously reported acetic acid-sensitive histone mutants. Revalidation using spottest assays and growth curves revealed that five of these mutants, viz., H3K18Q, H3S28A, H3K42Q, H3Q68A, and H3F104A, are most sensitive towards the tested acetic acid concentrations. These mutants demonstrated enhanced acetic acid stress response as evi-denced by the increased expression levels of AIF1, reactive oxygen species (ROS) generation, chromatin fragmentation, and aggregated actin cytoskeleton. Additionally, the mutants exhibited active cell wall damage response upon acetic acid treatment, as demonstrated by increased Slt2-phosphorylation and expression of cell wall integrity genes. Interestingly, the mutants demonstrated increased sensitivity to cell wall stress-causing agents. Finally, screening of histone H3 N-terminal tail truncation mutants revealed that the tail truncations exhibit general sensitivity to acetic acid stress. Some of these N-terminal tail truncation mutants viz., H3 [del 1-24], H3 [del 1-28], H3 [del 9-24], and H3 [del 25-36] are also sensitive to cell wall stress agents such as Congo red and caffeine suggesting that their enhanced acetic acid sensitivity may be due to cell wall stress induced by acetic acid." @default.
- W4386886751 created "2023-09-21" @default.
- W4386886751 creator A5002134116 @default.
- W4386886751 creator A5007529008 @default.
- W4386886751 creator A5017878103 @default.
- W4386886751 date "2023-10-02" @default.
- W4386886751 modified "2023-09-27" @default.
- W4386886751 title "Investigation of the acetic acid stress response in Saccharomyces cerevisiae with mutated H3 residues" @default.
- W4386886751 cites W1483456869 @default.
- W4386886751 cites W1964297184 @default.
- W4386886751 cites W1966072209 @default.
- W4386886751 cites W1968336392 @default.
- W4386886751 cites W1977088975 @default.
- W4386886751 cites W1989849863 @default.
- W4386886751 cites W2021327083 @default.
- W4386886751 cites W2025426978 @default.
- W4386886751 cites W2031048257 @default.
- W4386886751 cites W2031726991 @default.
- W4386886751 cites W2036717977 @default.
- W4386886751 cites W2038234852 @default.
- W4386886751 cites W2062686313 @default.
- W4386886751 cites W2063232329 @default.
- W4386886751 cites W2066253252 @default.
- W4386886751 cites W2066811267 @default.
- W4386886751 cites W2066962210 @default.
- W4386886751 cites W2067393096 @default.
- W4386886751 cites W2067820742 @default.
- W4386886751 cites W2068683690 @default.
- W4386886751 cites W2079122560 @default.
- W4386886751 cites W2080863659 @default.
- W4386886751 cites W2081702399 @default.
- W4386886751 cites W2083245183 @default.
- W4386886751 cites W2086202782 @default.
- W4386886751 cites W2098657730 @default.
- W4386886751 cites W2102678326 @default.
- W4386886751 cites W2107277218 @default.
- W4386886751 cites W2107624089 @default.
- W4386886751 cites W2108053853 @default.
- W4386886751 cites W2110971717 @default.
- W4386886751 cites W2111859500 @default.
- W4386886751 cites W2113857452 @default.
- W4386886751 cites W2117061686 @default.
- W4386886751 cites W2120903012 @default.
- W4386886751 cites W2121702473 @default.
- W4386886751 cites W2122853476 @default.
- W4386886751 cites W2129739437 @default.
- W4386886751 cites W2133143024 @default.
- W4386886751 cites W2136656652 @default.
- W4386886751 cites W2157305748 @default.
- W4386886751 cites W2157460441 @default.
- W4386886751 cites W2158906421 @default.
- W4386886751 cites W2163893998 @default.
- W4386886751 cites W2171671996 @default.
- W4386886751 cites W2172266573 @default.
- W4386886751 cites W2192080449 @default.
- W4386886751 cites W2460333367 @default.
- W4386886751 cites W2529600492 @default.
- W4386886751 cites W2558033160 @default.
- W4386886751 cites W2577411945 @default.
- W4386886751 cites W2588053842 @default.
- W4386886751 cites W2729255418 @default.
- W4386886751 cites W2735587792 @default.
- W4386886751 cites W2796199008 @default.
- W4386886751 cites W2810037075 @default.
- W4386886751 cites W2911237750 @default.
- W4386886751 cites W2966248107 @default.
- W4386886751 cites W3012183794 @default.
- W4386886751 cites W3048908565 @default.
- W4386886751 cites W3160162981 @default.
- W4386886751 cites W3162522770 @default.
- W4386886751 cites W3173834831 @default.
- W4386886751 cites W4288434539 @default.
- W4386886751 cites W4323255180 @default.
- W4386886751 doi "https://doi.org/10.15698/mic2023.10.806" @default.
- W4386886751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37746586" @default.
- W4386886751 hasPublicationYear "2023" @default.
- W4386886751 type Work @default.
- W4386886751 citedByCount "0" @default.
- W4386886751 crossrefType "journal-article" @default.
- W4386886751 hasAuthorship W4386886751A5002134116 @default.
- W4386886751 hasAuthorship W4386886751A5007529008 @default.
- W4386886751 hasAuthorship W4386886751A5017878103 @default.
- W4386886751 hasBestOaLocation W43868867511 @default.
- W4386886751 hasConcept C104317684 @default.
- W4386886751 hasConcept C143065580 @default.
- W4386886751 hasConcept C185592680 @default.
- W4386886751 hasConcept C2776673659 @default.
- W4386886751 hasConcept C2777576037 @default.
- W4386886751 hasConcept C2779222958 @default.
- W4386886751 hasConcept C55493867 @default.
- W4386886751 hasConcept C86803240 @default.
- W4386886751 hasConcept C95444343 @default.
- W4386886751 hasConceptScore W4386886751C104317684 @default.
- W4386886751 hasConceptScore W4386886751C143065580 @default.
- W4386886751 hasConceptScore W4386886751C185592680 @default.
- W4386886751 hasConceptScore W4386886751C2776673659 @default.
- W4386886751 hasConceptScore W4386886751C2777576037 @default.
- W4386886751 hasConceptScore W4386886751C2779222958 @default.