Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386887276> ?p ?o ?g. }
- W4386887276 endingPage "1751.e7" @default.
- W4386887276 startingPage "1736" @default.
- W4386887276 abstract "Muscle-residing regulatory T cells (Tregs) control local tissue integrity and function. However, the molecular interface connecting Treg-based regulation with muscle function and regeneration remains largely unexplored. Here, we show that exercise fosters a stable induction of highly functional muscle-residing Tregs with increased expression of amphiregulin (Areg), EGFR, and ST2. Mechanistically, we find that mice lacking IL6Rα on T cells (TKO) harbor significant reductions in muscle Treg functionality and satellite and fibro-adipogenic progenitor cells, which are required for muscle regeneration. Using exercise and sarcopenia models, IL6Rα TKO mice demonstrate deficits in Tregs, their functional maturation, and a more pronounced decline in muscle mass. Muscle injury models indicate that IL6Rα TKO mice have significant disabilities in muscle regeneration. Treg gain of function restores impaired muscle repair in IL6Rα TKO mice. Of note, pharmacological IL6R blockade in WT mice phenocopies deficits in muscle function identified in IL6Rα TKO mice, thereby highlighting the clinical implications of the findings." @default.
- W4386887276 created "2023-09-21" @default.
- W4386887276 creator A5000358288 @default.
- W4386887276 creator A5000459123 @default.
- W4386887276 creator A5010129646 @default.
- W4386887276 creator A5017277963 @default.
- W4386887276 creator A5023510306 @default.
- W4386887276 creator A5059836273 @default.
- W4386887276 creator A5063387242 @default.
- W4386887276 creator A5076337595 @default.
- W4386887276 creator A5091813249 @default.
- W4386887276 creator A5092908039 @default.
- W4386887276 date "2023-10-01" @default.
- W4386887276 modified "2023-10-17" @default.
- W4386887276 title "Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration" @default.
- W4386887276 cites W1142031920 @default.
- W4386887276 cites W1555821747 @default.
- W4386887276 cites W1969630360 @default.
- W4386887276 cites W1976852696 @default.
- W4386887276 cites W1987498610 @default.
- W4386887276 cites W1991163834 @default.
- W4386887276 cites W1999902156 @default.
- W4386887276 cites W2008264147 @default.
- W4386887276 cites W2010260569 @default.
- W4386887276 cites W2010957046 @default.
- W4386887276 cites W2011640487 @default.
- W4386887276 cites W2035324964 @default.
- W4386887276 cites W2038733101 @default.
- W4386887276 cites W2053271495 @default.
- W4386887276 cites W2054464764 @default.
- W4386887276 cites W2076327296 @default.
- W4386887276 cites W2083831897 @default.
- W4386887276 cites W2085182377 @default.
- W4386887276 cites W2090699565 @default.
- W4386887276 cites W2092917284 @default.
- W4386887276 cites W2100478793 @default.
- W4386887276 cites W2103488083 @default.
- W4386887276 cites W2104049583 @default.
- W4386887276 cites W2112039060 @default.
- W4386887276 cites W2125253058 @default.
- W4386887276 cites W2143168086 @default.
- W4386887276 cites W2147235183 @default.
- W4386887276 cites W2147652122 @default.
- W4386887276 cites W2151328705 @default.
- W4386887276 cites W2167279371 @default.
- W4386887276 cites W2269067703 @default.
- W4386887276 cites W2283665483 @default.
- W4386887276 cites W2298784209 @default.
- W4386887276 cites W244232182 @default.
- W4386887276 cites W2516794947 @default.
- W4386887276 cites W2542468576 @default.
- W4386887276 cites W2558510664 @default.
- W4386887276 cites W2603607779 @default.
- W4386887276 cites W2606480102 @default.
- W4386887276 cites W2611306777 @default.
- W4386887276 cites W2750977961 @default.
- W4386887276 cites W2754166148 @default.
- W4386887276 cites W2765400080 @default.
- W4386887276 cites W2766326897 @default.
- W4386887276 cites W2770005161 @default.
- W4386887276 cites W2782530117 @default.
- W4386887276 cites W2793413631 @default.
- W4386887276 cites W2800635498 @default.
- W4386887276 cites W2806425229 @default.
- W4386887276 cites W2856147029 @default.
- W4386887276 cites W2904289466 @default.
- W4386887276 cites W2905321820 @default.
- W4386887276 cites W2914818051 @default.
- W4386887276 cites W2944869407 @default.
- W4386887276 cites W2950341660 @default.
- W4386887276 cites W2964913070 @default.
- W4386887276 cites W2995933573 @default.
- W4386887276 cites W3000221858 @default.
- W4386887276 cites W3021867869 @default.
- W4386887276 cites W3111521801 @default.
- W4386887276 cites W3139105570 @default.
- W4386887276 cites W3164338402 @default.
- W4386887276 doi "https://doi.org/10.1016/j.cmet.2023.08.010" @default.
- W4386887276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37734370" @default.
- W4386887276 hasPublicationYear "2023" @default.
- W4386887276 type Work @default.
- W4386887276 citedByCount "0" @default.
- W4386887276 crossrefType "journal-article" @default.
- W4386887276 hasAuthorship W4386887276A5000358288 @default.
- W4386887276 hasAuthorship W4386887276A5000459123 @default.
- W4386887276 hasAuthorship W4386887276A5010129646 @default.
- W4386887276 hasAuthorship W4386887276A5017277963 @default.
- W4386887276 hasAuthorship W4386887276A5023510306 @default.
- W4386887276 hasAuthorship W4386887276A5059836273 @default.
- W4386887276 hasAuthorship W4386887276A5063387242 @default.
- W4386887276 hasAuthorship W4386887276A5076337595 @default.
- W4386887276 hasAuthorship W4386887276A5091813249 @default.
- W4386887276 hasAuthorship W4386887276A5092908039 @default.
- W4386887276 hasBestOaLocation W43868872761 @default.
- W4386887276 hasConcept C126322002 @default.
- W4386887276 hasConcept C134018914 @default.
- W4386887276 hasConcept C14036430 @default.
- W4386887276 hasConcept C170493617 @default.