Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386888894> ?p ?o ?g. }
- W4386888894 abstract "Abstract Background Endometrial injury is a common disease in women caused by intrauterine inflammation, infections, and endocrine disorders. Human endometrial stromal cells (hEndoSCs) can maintain endometrial homeostasis and play an important role in repairing endometrial injury. Mifepristone, a steroidal anti‐progesterone drug, is widely used in the field of reproductive medicine worldwide. Mifepristone‐induced hEndoSC injury has been used to study endometrial injury in vitro. At present, the pathogenesis and potential regulatory mechanisms of oxycodone in endometrial injury remain unknown. Aims We aimed to evaluate the functions of oxycodone in mifepristone‐stimulated hEndoSC injury and analyze its potential molecular mechanism. Materials & Methods hEndoSC viability, cytotoxicity, and apoptosis were analyzed using the methyl thiazolyl tetrazolium assay, the lactate dehydrogenase assay, and flow cytometry, respectively. Furthermore, the levels of cleaved‐Caspase3, Keap1, Nrf2, HO‐1, and NQO1 were assessed using reverse transcription quantitative polymerase chain reaction and western blot analysis, and the release of inflammatory cytokines was determined using the enzyme‐linked immunosorbent assay. Results We observed that oxycodone had no adverse effects on hEndoSCs; rather, it protected hEndoSCs against mifepristone‐induced endometrial damage, as confirmed by the enhanced cell viability, reduced number of apoptotic cells, decreased Caspase3 activity and inflammatory cytokine secretion, and increased Keap1/Nrf2/HO‐1 pathway‐related protein expression. In addition, we found that the protective effects of oxycodone on mifepristone‐induced hEndoSC injury were inhibited by ML385 (a Keap1/Nrf2/HO‐1 inhibitor). Conclusion In summary, we confirmed that oxycodone alleviates mifepristone‐induced hEndoSC injury by activating the Keap1/Nrf2/HO‐1 signaling pathway." @default.
- W4386888894 created "2023-09-21" @default.
- W4386888894 creator A5041213274 @default.
- W4386888894 creator A5046617581 @default.
- W4386888894 creator A5051721293 @default.
- W4386888894 date "2023-09-01" @default.
- W4386888894 modified "2023-10-02" @default.
- W4386888894 title "Oxycodone alleviates mifepristone‐stimulated human endometrial stromal cell injury by activating the Keap1/Nrf2/HO‐1 signaling pathway" @default.
- W4386888894 cites W2022950254 @default.
- W4386888894 cites W2043952204 @default.
- W4386888894 cites W2055350782 @default.
- W4386888894 cites W2101356852 @default.
- W4386888894 cites W2111723376 @default.
- W4386888894 cites W2132233375 @default.
- W4386888894 cites W2139744978 @default.
- W4386888894 cites W2167971907 @default.
- W4386888894 cites W2255376174 @default.
- W4386888894 cites W2471063129 @default.
- W4386888894 cites W2545733188 @default.
- W4386888894 cites W2756911838 @default.
- W4386888894 cites W2758553060 @default.
- W4386888894 cites W2889523999 @default.
- W4386888894 cites W2890293280 @default.
- W4386888894 cites W2941662881 @default.
- W4386888894 cites W2944527983 @default.
- W4386888894 cites W2966063711 @default.
- W4386888894 cites W2967076383 @default.
- W4386888894 cites W2989424577 @default.
- W4386888894 cites W2993308859 @default.
- W4386888894 cites W2996430425 @default.
- W4386888894 cites W2997920261 @default.
- W4386888894 cites W2999623704 @default.
- W4386888894 cites W3002054554 @default.
- W4386888894 cites W3005419559 @default.
- W4386888894 cites W3012416992 @default.
- W4386888894 cites W3016966753 @default.
- W4386888894 cites W3016990397 @default.
- W4386888894 cites W3025725330 @default.
- W4386888894 cites W3080272592 @default.
- W4386888894 cites W3084364421 @default.
- W4386888894 cites W3084513509 @default.
- W4386888894 cites W3094208943 @default.
- W4386888894 cites W3156890645 @default.
- W4386888894 cites W3170893295 @default.
- W4386888894 cites W3175381840 @default.
- W4386888894 cites W4213453853 @default.
- W4386888894 cites W4225327478 @default.
- W4386888894 cites W4285402104 @default.
- W4386888894 cites W4308616302 @default.
- W4386888894 cites W4309549851 @default.
- W4386888894 doi "https://doi.org/10.1002/iid3.1008" @default.
- W4386888894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37773689" @default.
- W4386888894 hasPublicationYear "2023" @default.
- W4386888894 type Work @default.
- W4386888894 citedByCount "0" @default.
- W4386888894 crossrefType "journal-article" @default.
- W4386888894 hasAuthorship W4386888894A5041213274 @default.
- W4386888894 hasAuthorship W4386888894A5046617581 @default.
- W4386888894 hasAuthorship W4386888894A5051721293 @default.
- W4386888894 hasBestOaLocation W43868888941 @default.
- W4386888894 hasConcept C126322002 @default.
- W4386888894 hasConcept C16930146 @default.
- W4386888894 hasConcept C170493617 @default.
- W4386888894 hasConcept C185592680 @default.
- W4386888894 hasConcept C190283241 @default.
- W4386888894 hasConcept C2776029756 @default.
- W4386888894 hasConcept C2778826759 @default.
- W4386888894 hasConcept C2779234561 @default.
- W4386888894 hasConcept C2781063702 @default.
- W4386888894 hasConcept C502942594 @default.
- W4386888894 hasConcept C53227056 @default.
- W4386888894 hasConcept C54355233 @default.
- W4386888894 hasConcept C55493867 @default.
- W4386888894 hasConcept C71924100 @default.
- W4386888894 hasConcept C86803240 @default.
- W4386888894 hasConcept C98274493 @default.
- W4386888894 hasConceptScore W4386888894C126322002 @default.
- W4386888894 hasConceptScore W4386888894C16930146 @default.
- W4386888894 hasConceptScore W4386888894C170493617 @default.
- W4386888894 hasConceptScore W4386888894C185592680 @default.
- W4386888894 hasConceptScore W4386888894C190283241 @default.
- W4386888894 hasConceptScore W4386888894C2776029756 @default.
- W4386888894 hasConceptScore W4386888894C2778826759 @default.
- W4386888894 hasConceptScore W4386888894C2779234561 @default.
- W4386888894 hasConceptScore W4386888894C2781063702 @default.
- W4386888894 hasConceptScore W4386888894C502942594 @default.
- W4386888894 hasConceptScore W4386888894C53227056 @default.
- W4386888894 hasConceptScore W4386888894C54355233 @default.
- W4386888894 hasConceptScore W4386888894C55493867 @default.
- W4386888894 hasConceptScore W4386888894C71924100 @default.
- W4386888894 hasConceptScore W4386888894C86803240 @default.
- W4386888894 hasConceptScore W4386888894C98274493 @default.
- W4386888894 hasIssue "9" @default.
- W4386888894 hasLocation W43868888941 @default.
- W4386888894 hasLocation W43868888942 @default.
- W4386888894 hasOpenAccess W4386888894 @default.
- W4386888894 hasPrimaryLocation W43868888941 @default.
- W4386888894 hasRelatedWork W2061808028 @default.
- W4386888894 hasRelatedWork W2347359022 @default.
- W4386888894 hasRelatedWork W2350922817 @default.