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- W4386890201 abstract "Abstract Galantamine, a centrally acting acetylcholinesterase inhibitor, has been shown to attenuate inflammation and insulin resistance in patients with metabolic syndrome. We investigated the effects of galantamine on glycemic control and development of diabetic nephropathy (DN) in Lepr db/db mice. Galantamine significantly reduced food intake, body weight, blood glucose and HbA1c levels. Insulin resistance (HOMA-IR, QUICKI), HOMA-β and elevations in plasma inflammatory cytokine levels (TNF-α, IL-6 and HMGB-1) were all attenuated by galantamine. Galantamine also ameliorated diabetes-induced kidney injury as evidenced by improvements in renal function (BUN, creatinine, albuminuria), histologic injury and apoptosis. Improved glycemic control and nephropathy were associated with increased circulating GLP-1, decreased renal P-38 MAPK and caspase-1 activation and reduced SGLT-2 expression. These findings provide insights into the mechanisms by which galantamine improves glycemic control and attenuates DN in the Lepr db/db mouse model." @default.
- W4386890201 created "2023-09-21" @default.
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- W4386890201 date "2023-09-20" @default.
- W4386890201 modified "2023-10-14" @default.
- W4386890201 title "Galantamine improves glycemic control and diabetic nephropathy in Leprdb/db mice" @default.
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- W4386890201 doi "https://doi.org/10.1038/s41598-023-42665-2" @default.
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