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• W4386890944 abstract "<ns4:p><ns4:bold>Background: </ns4:bold>Mozambique has the 4<ns4:sup>th</ns4:sup> highest malaria incidence and mortality globally. Despite the existing malaria control strategies, malaria prevalence remains stagnant. These challenges have increased calls for innovative strategies in areas with the highest disease burden. Community mass treatment with anthelmintic agents have been used as an effective tool for the control of major helminth infections and has emerged as a potential tool for vector control in the fight against malaria.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>This was an analysis of data from a cross-sectional community-based survey designed to study malaria risk, prevention, and health seeking behaviors in Sussundenga, Mozambique. Using logistic regression models, we quantified the association between ever receiving anthelmintic treatment and <ns4:italic>P. falciparum</ns4:italic> infection. We also fit models to determine the association between recent anthelmintic treatment and malaria infection.</ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>Two-hundred, seventy-seven (277) participants from 83 households were included in this analysis. The prevalence of <ns4:italic>P. falciparum</ns4:italic> infection measured by rapid diagnostic test (RDT) was 30%. 77% of participants reported having ever received anthelmintics. The prevalence of malaria was slightly higher among participants who reported ever taking anthelmintics. There was no statistically significant association between prior receipt of anthelmintic and <ns4:italic>P. falciparum</ns4:italic> malaria infection after adjusting for age, ITN use and head of household full-time employment (OR = 1.37, 95% CI, 0.70–2.70, p = 0.36). However, recent intake of anthelmintics was associated with lower odds of testing positive for in the adjusted models (OR = 0.35, 95% CI, 0.07–1.80, p = 0.21), but this was not statistically significant.</ns4:p><ns4:p> <ns4:bold>Conclusions: </ns4:bold>Our findings show that the benefit of anthelmintics treatment as a control tool for <ns4:italic>P. falciparum </ns4:italic>malaria infection is likely tied to when it is administered rather than if it was ever administered. These findings offer evidence for making decisions in planning mass community deworming in sub-Saharan Africa.</ns4:p>" @default.
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• W4386890944 date "2023-09-20" @default.
• W4386890944 modified "2023-10-13" @default.
• W4386890944 title "Association of anthelmintic treatment with malaria prevalence in Rural Sussundenga, Mozambique" @default.
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• W4386890944 doi "https://doi.org/10.12688/wellcomeopenres.19548.1" @default.
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