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- W4386891163 abstract "<p class=MsoNormal style=margin-bottom: .0001pt; text-align: justify; line-height: 150%; direction: ltr; unicode-bidi: embed;><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;>Diloxanide furoate (DXF) and Metronidazole (MTZ) are commonly combined as a binary mixture for the treatment of a variety of diseases brought on by bacteria and parasites including </span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; background: white;>amoebiasis and giardiasis. Different analytical methods were established for determination of both DXF and MTZ, </span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;>However, only one chemometric spectrophotometric method was established for their stability indicating determination which involves problematical steps and specific software program. Herein, </span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; letter-spacing: -.2pt;>double divisor ratio spectra derivative (DDRSD) method</span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;> is exploited for quantification of DXF and MTZ in presence of DXF-degradation products (FUR and DEG). The recommended </span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; letter-spacing: -.2pt;>DDRSD</span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;> method is linear over the range of </span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi;>2–25 and 1–25 µg/mL for DXF and MTZ, correspondingly. Additionally, the suggested method was effectively employed to their pharmaceutical formulations with good findings. Besides, the recommended <span style=letter-spacing: -.2pt;>DDRSD</span></span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;> method was validated </span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi;>conforming to ICH guidelines. The introduced <span style=letter-spacing: -.2pt;>DDRSD</span></span><span style=font-size: 10.0pt; line-height: 150%; font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-font-family: Arial; mso-bidi-theme-font: minor-bidi; mso-bidi-language: AR-EG;> method is simple, selective, and economic and could be implemented for quality control samples of the studied drugs.</span></p>" @default.
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- W4386891163 date "2023-09-19" @default.
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- W4386891163 title "Stability Indicating Double Divisor Spectrophotometric Method for determination of Diloxanide Furoate and Metronidazole in Their Binary Mixture" @default.
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