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• W4386892070 abstract "This study assesses the infrainguinal successful endovascular treatment (iSET) score’s ability to predict risk of open revascularization in patients undergoing endovascular revascularization (ER) for infrainguinal chronic limb-threatening ischemia (CLTI). The iSET is a score between 1 and 63. It combines components of the Global Vascular Guidelines evidence-based revascularization as follows: iSET = WIfI 2 + inflow disease + 4 × GLASS FP + 6 × GLASS IP + 3 × IM pedal modifier The score was used in a retrospective analysis of consecutive patients with CLTI between January 2015 and December 2018. Patients were stratified into low (0-21), moderate (22-42), and high (43-63). The primary outcome was freedom from open revascularization at 2 years. The study included 159 limbs in 150 patients with 12% (n = 19), 53% (n = 84), and 35% (n = 56) having low, moderate, and high iSET scores respectively. Most patients presented with tissue loss (86%), WIfI stage 4 (64%), and GLASS III (47%). Patients with a high iSET were more likely to have received antibiotics prior to ER (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.08-1.70; P = .013) and less likely to have elective ER (OR, 0.36; 95% CI, 0.18-0.72; P = .003). Kaplan-Meier survival curves showed that 2-year freedom from open revascularization was 100%, 93%, and 79% with low, moderate, and high iSET, respectively (Fig 1). Mortality, reinterventions, and major amputations were similar at 30 days and 1 year (Table I). High iSET score predicted increased risk of open revascularization (hazard ratio, 4.75; 95% CI, 1.67-13.48; P = .003) in the cohort. The iSET is a novel comprehensive score incorporating guideline-driven parameters. It is a good prognostic tool for predicting freedom from open revascularization after ER. Further studies are needed to validate it as an adjunct tool in managing patients with CLTI.Table 1Thirty-day and 1-year outcomes in patients stratified by groupsOverallLowModerateHighP-value30-day Death2 (3)03 (2)2 (1).775 Endovascular reintervention8 (11)08 (6)10 (5).447 Major amputation2 (2)02 (1)3 (1).848 Minor amputation13 (18)6 (1)8 (6)21 (11).0861-year Death11 (15)013 (9)11 (6).334 Endovascular reintervention34 (48)31 (5)33 (24)37 (19).885 Major amputation13 (18)014 (10)15 (8).262 Minor amputation25 (36)6 (1)21 (15)38 (20).016Data are presented as percent (number). Open table in a new tab" @default.
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• W4386892070 date "2023-10-01" @default.
• W4386892070 modified "2023-09-27" @default.
• W4386892070 title "A Novel Clinico-anatomical Score Predicts Endovascular Failure in Patients With Chronic Limb-threatening Ischemia" @default.
• W4386892070 doi "https://doi.org/10.1016/j.jvs.2023.08.090" @default.
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