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- W4386895805 abstract "Concern about possible cross sensitivity between cefazolin and penicillin leads to restrictions on the use of penicillin in patients with cefazolin hypersensitivity reactions and no history of penicillin allergy. Our study aims to document the prevalence of penicillin cross sensitivity in this patient cohort. Sixty-eight adult patients who were seen at our clinic with confirmed cefazolin hypersensitivity reactions during the ten-year study period (2009–2018) were investigated for allergy to penicillin. Demonstration of penicillin tolerance was by a combination of penicillin skin testing, penicillin drug provocation testing (DPT) and community exposure to penicillin. There were no positive penicillin DPTs or reported reactions to penicillins in the community in our cohort. There were six false positive penicillin skin test results. Four patients were lost to follow up. We conclude that allergy to penicillin is uncommon in patients with confirmed hypersensitivity to cefazolin. Penicillin skin testing in this cohort of patients is time consuming, costly, and unreliable with a significant rate of false positives which may lead to patients being inappropriately labelled as penicillin allergic." @default.
- W4386895805 created "2023-09-21" @default.
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- W4386895805 date "2023-09-20" @default.
- W4386895805 modified "2023-09-27" @default.
- W4386895805 title "Retrospective observational study of penicillin cross-sensitivity in patients with confirmed perioperative allergic hypersensitivity reactions to cefazolin." @default.
- W4386895805 doi "https://doi.org/10.22541/au.169518607.70484413/v1" @default.
- W4386895805 hasPublicationYear "2023" @default.
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