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- W4386896247 abstract "Colorectal liver metastases (CRLM) patients combined with hepatic lymph node metastases was a negative prognostic factor associated with outcomes. Up to now, there was still lack of a reliable method to identify the status of hepatic lymph nodes. The aim of this study was to investigate the predictive ability of mono-exponential, bi-exponential, and stretched-exponential diffusion-weighted imaging (DWI) models to distinguish between benign and malignant hepatic lymph nodes in CRLM patients who underwent neoadjuvant chemotherapy prior to surgery. In total, 97 CRLM patients with pathologically proved hepatic lymph node status were included. Various quantitative parameters, including the apparent diffusion coefficient (ADC) from mono-exponential model, D, D*, and f derived from intravoxel incoherent motion (IVIM) model, as well as DDC and α from stretched-exponential model (SEM), were measured. Multivariate analysis revealed that the pre- treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes. A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients, with an area under the curve (AUC) of 0.873. Therefore, the nomogram can serve as a preoperative assessment tool for determining the status of hepatic lymph nodes and aiding in the decision-making process for surgical treatment in CRLM patients." @default.
- W4386896247 created "2023-09-21" @default.
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- W4386896247 date "2023-09-19" @default.
- W4386896247 modified "2023-09-27" @default.
- W4386896247 title "Comparison of the Diagnostic Value of Mono-Exponential, Bi-Exponential, and Stretched Exponential Diffusion-Weighted MRI to Predict Hepatic Lymph Node Metastases in Patients with Colorectal Liver Metastases after Chemotherapy" @default.
- W4386896247 doi "https://doi.org/10.20944/preprints202309.1264.v1" @default.
- W4386896247 hasPublicationYear "2023" @default.
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