Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386897855> ?p ?o ?g. }
- W4386897855 endingPage "107964" @default.
- W4386897855 startingPage "107964" @default.
- W4386897855 abstract "The Polycomb group protein SCML2 and the transcriptional cofactor YAP1 regulate diverse cellular biology, including stem cell maintenance, developmental processes, and gene regulation in mammals and flies. However, their molecular and functional interactions are unknown. Here, we show that SCML2 interacts with YAP1, as revealed by immunological assays and mass spectroscopy. We have demonstrated that the steroid hormone androgen regulates the interaction of SCML2 with YAP1 in human tumor cell models. Our proximity ligation assay and GST pulldown showed that SCML2 and YAP1 physically interacted with each other. Silencing SCML2 by RNAi changed the growth behaviors of cells in response to androgen signaling. Mechanistically, this phenomenon is attributed to the interplay between distinct chromatin modifications and transcriptional programs, likely coordinated by the opposing SCML2 and YAP1 activity. These findings suggest that YAP1 and SCML2 cooperate to regulate cell growth, cell survival, and tumor biology downstream of steroid hormones." @default.
- W4386897855 created "2023-09-21" @default.
- W4386897855 creator A5003746258 @default.
- W4386897855 creator A5016616264 @default.
- W4386897855 creator A5018204445 @default.
- W4386897855 creator A5039837606 @default.
- W4386897855 creator A5048956986 @default.
- W4386897855 creator A5078595868 @default.
- W4386897855 creator A5043438052 @default.
- W4386897855 creator A5050510415 @default.
- W4386897855 date "2023-10-01" @default.
- W4386897855 modified "2023-10-11" @default.
- W4386897855 title "Discordant interactions between YAP1 and Polycomb group protein SCML2 determine cell fate" @default.
- W4386897855 cites W1968027040 @default.
- W4386897855 cites W1974330670 @default.
- W4386897855 cites W1975702835 @default.
- W4386897855 cites W1982953415 @default.
- W4386897855 cites W1987049707 @default.
- W4386897855 cites W1999228297 @default.
- W4386897855 cites W2009076537 @default.
- W4386897855 cites W2013832080 @default.
- W4386897855 cites W2022316591 @default.
- W4386897855 cites W2024605154 @default.
- W4386897855 cites W2028003321 @default.
- W4386897855 cites W2029061012 @default.
- W4386897855 cites W2053317015 @default.
- W4386897855 cites W2060870400 @default.
- W4386897855 cites W2075205811 @default.
- W4386897855 cites W2080682888 @default.
- W4386897855 cites W2085039090 @default.
- W4386897855 cites W2087766778 @default.
- W4386897855 cites W2088910050 @default.
- W4386897855 cites W2093396457 @default.
- W4386897855 cites W2093800333 @default.
- W4386897855 cites W2098692163 @default.
- W4386897855 cites W2106401943 @default.
- W4386897855 cites W2113087175 @default.
- W4386897855 cites W2114843025 @default.
- W4386897855 cites W2124574849 @default.
- W4386897855 cites W2139025888 @default.
- W4386897855 cites W2149441684 @default.
- W4386897855 cites W2156854438 @default.
- W4386897855 cites W2168534340 @default.
- W4386897855 cites W2244948668 @default.
- W4386897855 cites W2426003472 @default.
- W4386897855 cites W2565967823 @default.
- W4386897855 cites W2585920126 @default.
- W4386897855 cites W2614669617 @default.
- W4386897855 cites W2788760640 @default.
- W4386897855 cites W2800619817 @default.
- W4386897855 cites W2884914303 @default.
- W4386897855 cites W2885238674 @default.
- W4386897855 cites W2893590138 @default.
- W4386897855 cites W2898723593 @default.
- W4386897855 cites W2905097208 @default.
- W4386897855 cites W2944077036 @default.
- W4386897855 cites W2945647183 @default.
- W4386897855 cites W2953191262 @default.
- W4386897855 cites W2954828863 @default.
- W4386897855 cites W3021653784 @default.
- W4386897855 cites W3025917918 @default.
- W4386897855 cites W3082264507 @default.
- W4386897855 cites W3112996818 @default.
- W4386897855 cites W3121104869 @default.
- W4386897855 cites W3136393910 @default.
- W4386897855 cites W3193447048 @default.
- W4386897855 cites W3204751963 @default.
- W4386897855 cites W4200077999 @default.
- W4386897855 cites W4205324938 @default.
- W4386897855 cites W4221048326 @default.
- W4386897855 doi "https://doi.org/10.1016/j.isci.2023.107964" @default.
- W4386897855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37810219" @default.
- W4386897855 hasPublicationYear "2023" @default.
- W4386897855 type Work @default.
- W4386897855 citedByCount "0" @default.
- W4386897855 crossrefType "journal-article" @default.
- W4386897855 hasAuthorship W4386897855A5003746258 @default.
- W4386897855 hasAuthorship W4386897855A5016616264 @default.
- W4386897855 hasAuthorship W4386897855A5018204445 @default.
- W4386897855 hasAuthorship W4386897855A5039837606 @default.
- W4386897855 hasAuthorship W4386897855A5043438052 @default.
- W4386897855 hasAuthorship W4386897855A5048956986 @default.
- W4386897855 hasAuthorship W4386897855A5050510415 @default.
- W4386897855 hasAuthorship W4386897855A5078595868 @default.
- W4386897855 hasBestOaLocation W43868978551 @default.
- W4386897855 hasConcept C104317684 @default.
- W4386897855 hasConcept C119056186 @default.
- W4386897855 hasConcept C1491633281 @default.
- W4386897855 hasConcept C158448853 @default.
- W4386897855 hasConcept C166703698 @default.
- W4386897855 hasConcept C2777116130 @default.
- W4386897855 hasConcept C2780219982 @default.
- W4386897855 hasConcept C28328180 @default.
- W4386897855 hasConcept C54355233 @default.
- W4386897855 hasConcept C62112901 @default.
- W4386897855 hasConcept C67705224 @default.
- W4386897855 hasConcept C83640560 @default.
- W4386897855 hasConcept C86339819 @default.