FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386898478> ?p ?o ?g. }

• W4386898478 endingPage "110719" @default.
• W4386898478 startingPage "110719" @default.
• W4386898478 abstract "Fluoride (F), widely present in water and food, poses a serious threat to liver health, and oxidative damage and mitochondrial damage are its main causes. As a natural mitochondrial protector and antioxidant, α-lipoic acid (ALA)'s alleviating effect on fluorosis liver injury and its underlying mechanism are still unclear. Therefore, this study established a fluorosis ALA intervention mice model to explore the mechanism of mitochondrial biogenesis, mitochondrial dynamics, and Wnt/Ca2+ pathway in ALA attenuating fluorosis liver injury. The results showed that ALA mitigated F-induced weight loss, hepatic structural and functional damage, hepatocytes mitochondrial damage, and decreased antioxidant levels. However, ALA did not reduce F accumulation in the femur. Further mRNA and protein detection results showed that F increased the expression levels of key genes in the mitochondrial fission (Drp1, Mff, and Fis1), mitophagy (Parkin, Pink1, and Prdx3), Wnt/Ca2+ pathway (Wnt5a and CaMK2), and rised the number and intensity of fluorescent spots of Drp1, but decreased the expression levels of key genes in the mitochondrial biogenesis (Sirt1, Sirt3, and PGC-1α) and fusion (OPA1, Mfn2, and Mfn1), and reduced the number and intensity of fluorescent spots of PGC-1α in the liver. However, the intervention of ALA relieved the F-induced changes in the expressions of the above genes. In conclusion, ALA mitigated F-induced hepatic injury through enhancing antioxidant capacity and inhibiting Wnt/Ca2+ pathway to improve mitochondrial biogenesis and dynamics disturbance. This study further reveals the hepatotoxic mechanism of F and the protective mechanism of ALA, and provides a theoretical basis for ALA as a potential preventive and palliative agent for F-induced hepatotoxic injury." @default.
• W4386898478 created "2023-09-21" @default.
• W4386898478 creator A5011787061 @default.
• W4386898478 creator A5016270639 @default.
• W4386898478 creator A5031438011 @default.
• W4386898478 creator A5035167129 @default.
• W4386898478 creator A5065197431 @default.
• W4386898478 creator A5067868267 @default.
• W4386898478 creator A5077000248 @default.
• W4386898478 creator A5085279437 @default.
• W4386898478 creator A5088461704 @default.
• W4386898478 date "2023-11-01" @default.
• W4386898478 modified "2023-10-17" @default.
• W4386898478 title "α-Lipoic acid improves mitochondrial biogenesis and dynamics by enhancing antioxidant and inhibiting Wnt/Ca2+ pathway to relieve fluoride-induced hepatotoxic injury" @default.
• W4386898478 cites W1494249446 @default.
• W4386898478 cites W1532641795 @default.
• W4386898478 cites W1540565773 @default.
• W4386898478 cites W1780408515 @default.
• W4386898478 cites W2006696253 @default.
• W4386898478 cites W2035103791 @default.
• W4386898478 cites W2143410022 @default.
• W4386898478 cites W2152165298 @default.
• W4386898478 cites W2573876164 @default.
• W4386898478 cites W2730832611 @default.
• W4386898478 cites W2742558281 @default.
• W4386898478 cites W2772709248 @default.
• W4386898478 cites W2791755317 @default.
• W4386898478 cites W2792010190 @default.
• W4386898478 cites W2907620367 @default.
• W4386898478 cites W2917426051 @default.
• W4386898478 cites W2952252112 @default.
• W4386898478 cites W2968122924 @default.
• W4386898478 cites W2979590612 @default.
• W4386898478 cites W2980020667 @default.
• W4386898478 cites W3016809142 @default.
• W4386898478 cites W3045091144 @default.
• W4386898478 cites W3081252359 @default.
• W4386898478 cites W3093699410 @default.
• W4386898478 cites W3094104800 @default.
• W4386898478 cites W3108549714 @default.
• W4386898478 cites W3122142817 @default.
• W4386898478 cites W3126704263 @default.
• W4386898478 cites W3197959919 @default.
• W4386898478 cites W4223496067 @default.
• W4386898478 cites W4224060445 @default.
• W4386898478 cites W4283219606 @default.
• W4386898478 cites W4291302513 @default.
• W4386898478 cites W4292425145 @default.
• W4386898478 cites W4304688775 @default.
• W4386898478 cites W4304689782 @default.
• W4386898478 cites W4307871205 @default.
• W4386898478 cites W4312070605 @default.
• W4386898478 cites W4313334246 @default.
• W4386898478 cites W4319454632 @default.
• W4386898478 cites W4319869222 @default.
• W4386898478 cites W4323569251 @default.
• W4386898478 cites W4323652144 @default.
• W4386898478 cites W4324121813 @default.
• W4386898478 cites W4327545966 @default.
• W4386898478 cites W4327896585 @default.
• W4386898478 cites W4328053694 @default.
• W4386898478 cites W4362523008 @default.
• W4386898478 cites W4362657000 @default.
• W4386898478 cites W4381051250 @default.
• W4386898478 doi "https://doi.org/10.1016/j.cbi.2023.110719" @default.
• W4386898478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37739047" @default.
• W4386898478 hasPublicationYear "2023" @default.
• W4386898478 type Work @default.
• W4386898478 citedByCount "0" @default.
• W4386898478 crossrefType "journal-article" @default.
• W4386898478 hasAuthorship W4386898478A5011787061 @default.
• W4386898478 hasAuthorship W4386898478A5016270639 @default.
• W4386898478 hasAuthorship W4386898478A5031438011 @default.
• W4386898478 hasAuthorship W4386898478A5035167129 @default.
• W4386898478 hasAuthorship W4386898478A5065197431 @default.
• W4386898478 hasAuthorship W4386898478A5067868267 @default.
• W4386898478 hasAuthorship W4386898478A5077000248 @default.
• W4386898478 hasAuthorship W4386898478A5085279437 @default.
• W4386898478 hasAuthorship W4386898478A5088461704 @default.
• W4386898478 hasConcept C104317684 @default.
• W4386898478 hasConcept C163950672 @default.
• W4386898478 hasConcept C169415338 @default.
• W4386898478 hasConcept C185592680 @default.
• W4386898478 hasConcept C190283241 @default.
• W4386898478 hasConcept C203522944 @default.
• W4386898478 hasConcept C24586158 @default.
• W4386898478 hasConcept C2776637226 @default.
• W4386898478 hasConcept C2776804853 @default.
• W4386898478 hasConcept C2777092462 @default.
• W4386898478 hasConcept C2777229759 @default.
• W4386898478 hasConcept C2777591492 @default.
• W4386898478 hasConcept C2777755479 @default.
• W4386898478 hasConcept C2779324830 @default.
• W4386898478 hasConcept C28859421 @default.
• W4386898478 hasConcept C55493867 @default.
• W4386898478 hasConcept C86803240 @default.
• W4386898478 hasConcept C95444343 @default.
• W4386898478 hasConcept C98274493 @default.

• next