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• W4386898623 abstract "Immune checkpoint inhibitors (ICIs) have shown growing promise in treatment of brain metastases, especially combined with stereotactic radiosurgery (SRS). The combination of ICIs with SRS has been studied for efficacy as well as increasing radiation necrosis risks. In this review, we compare clinical outcomes of radiation necrosis, intracranial control, and overall survival between patients with brain metastases treated with either SRS alone or SRS-ICI combination therapy.A literature search of PubMed, Scopus, Embase, Web of Science and Cochrane was performed in May 2023 for articles comparing the safety and efficacy of SRS/ICI versus SRS-alone for treating brain metastases.The search criteria identified 1961 articles, of which 48 met inclusion criteria. Combination therapy with SRS and ICI does not lead to significant increases in incidence of radiation necrosis either radiographically or symptomatically. Overall, no difference was found in intracranial control between SRS-alone and SRS/ICI combination therapy. Combination therapy is associated with increased median overall survival. Notably some comparative studies observed decreased neurologic deaths challenging presumptions that improved survival is due to greater systemic control. The literature supports SRS/ICI administration within 4 weeks of another for survival but remains inconclusive, requiring further study for other outcome measures.Combination SRS/ICI therapy is associated with significant overall survival benefit for patients with brain metastases without significantly increasing radiation necrosis risks compared to SRS alone. Although intracranial control rates appear to be similar between the two groups, timing of treatment delivery may improve control rates and demands further study attention." @default.
• W4386898623 created "2023-09-21" @default.
• W4386898623 creator A5010498394 @default.
• W4386898623 creator A5016408304 @default.
• W4386898623 creator A5017602675 @default.
• W4386898623 creator A5020199086 @default.
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• W4386898623 creator A5085549922 @default.
• W4386898623 date "2023-09-01" @default.
• W4386898623 modified "2023-10-18" @default.
• W4386898623 title "The Safety and Efficacy of Concurrent Immune Checkpoint Blockade and Stereotactic Radiosurgery Therapy with Practitioner and Researcher Recommendations" @default.
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