Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386909786> ?p ?o ?g. }
- W4386909786 abstract "Background: Histone deacetylases (HDACs) play a vital role in the epigenetic regulation of transcription and expression. HDAC1 overexpression is seen in many cancers. Methodology: The authors synthesized and evaluated 27 novel coumarin-based amide derivatives for HDAC1 inhibitory activity. The compounds were screened at the US National Cancer Institute, and 5k and 5u were selected for five-dose assays. Compound 5k showed GI50 values of 0.294 and 0.264 μM against MOLT-4 and LOX-IMVI, whereas 5u had GI50 values of 0.189 and 0.263 μM, respectively. Both derivatives showed better activity than entinostat and suberoylanilide hydroxamic acid. Compound 5k exhibited an IC50 value of 1.00 μM on ACHN cells. Conclusion: Coumarin derivatives exhibited promising HDAC1 inhibitory potential and warrant future development as anticancer agents." @default.
- W4386909786 created "2023-09-22" @default.
- W4386909786 creator A5009796917 @default.
- W4386909786 creator A5010833213 @default.
- W4386909786 creator A5011492478 @default.
- W4386909786 creator A5019169840 @default.
- W4386909786 creator A5035929598 @default.
- W4386909786 creator A5040093727 @default.
- W4386909786 creator A5046942387 @default.
- W4386909786 creator A5061863513 @default.
- W4386909786 creator A5063904669 @default.
- W4386909786 creator A5074938775 @default.
- W4386909786 creator A5087972362 @default.
- W4386909786 date "2023-09-21" @default.
- W4386909786 modified "2023-10-16" @default.
- W4386909786 title "Synthesis and HDAC1 inhibitory activity of a novel series of coumarin-based amide derivatives for treatment of cancer" @default.
- W4386909786 cites W1970721302 @default.
- W4386909786 cites W2078211225 @default.
- W4386909786 cites W2111163322 @default.
- W4386909786 cites W2112046350 @default.
- W4386909786 cites W2165596895 @default.
- W4386909786 cites W2521317541 @default.
- W4386909786 cites W2552229243 @default.
- W4386909786 cites W2595278577 @default.
- W4386909786 cites W2601738592 @default.
- W4386909786 cites W2604759877 @default.
- W4386909786 cites W2613935726 @default.
- W4386909786 cites W2620665957 @default.
- W4386909786 cites W2724336500 @default.
- W4386909786 cites W2741023921 @default.
- W4386909786 cites W2771421330 @default.
- W4386909786 cites W2785854718 @default.
- W4386909786 cites W2792207721 @default.
- W4386909786 cites W2795208162 @default.
- W4386909786 cites W3012633978 @default.
- W4386909786 cites W3047987759 @default.
- W4386909786 cites W3196577746 @default.
- W4386909786 cites W3202916369 @default.
- W4386909786 cites W4200436258 @default.
- W4386909786 doi "https://doi.org/10.4155/fmc-2023-0105" @default.
- W4386909786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37732405" @default.
- W4386909786 hasPublicationYear "2023" @default.
- W4386909786 type Work @default.
- W4386909786 citedByCount "0" @default.
- W4386909786 crossrefType "journal-article" @default.
- W4386909786 hasAuthorship W4386909786A5009796917 @default.
- W4386909786 hasAuthorship W4386909786A5010833213 @default.
- W4386909786 hasAuthorship W4386909786A5011492478 @default.
- W4386909786 hasAuthorship W4386909786A5019169840 @default.
- W4386909786 hasAuthorship W4386909786A5035929598 @default.
- W4386909786 hasAuthorship W4386909786A5040093727 @default.
- W4386909786 hasAuthorship W4386909786A5046942387 @default.
- W4386909786 hasAuthorship W4386909786A5061863513 @default.
- W4386909786 hasAuthorship W4386909786A5063904669 @default.
- W4386909786 hasAuthorship W4386909786A5074938775 @default.
- W4386909786 hasAuthorship W4386909786A5087972362 @default.
- W4386909786 hasConcept C104317684 @default.
- W4386909786 hasConcept C169760540 @default.
- W4386909786 hasConcept C17077164 @default.
- W4386909786 hasConcept C178790620 @default.
- W4386909786 hasConcept C185592680 @default.
- W4386909786 hasConcept C202751555 @default.
- W4386909786 hasConcept C2776281265 @default.
- W4386909786 hasConcept C2777752112 @default.
- W4386909786 hasConcept C2777752497 @default.
- W4386909786 hasConcept C2778305200 @default.
- W4386909786 hasConcept C2778439535 @default.
- W4386909786 hasConcept C2781338262 @default.
- W4386909786 hasConcept C41091548 @default.
- W4386909786 hasConcept C502942594 @default.
- W4386909786 hasConcept C55493867 @default.
- W4386909786 hasConcept C64927066 @default.
- W4386909786 hasConcept C71240020 @default.
- W4386909786 hasConcept C85240754 @default.
- W4386909786 hasConcept C86803240 @default.
- W4386909786 hasConcept C98274493 @default.
- W4386909786 hasConceptScore W4386909786C104317684 @default.
- W4386909786 hasConceptScore W4386909786C169760540 @default.
- W4386909786 hasConceptScore W4386909786C17077164 @default.
- W4386909786 hasConceptScore W4386909786C178790620 @default.
- W4386909786 hasConceptScore W4386909786C185592680 @default.
- W4386909786 hasConceptScore W4386909786C202751555 @default.
- W4386909786 hasConceptScore W4386909786C2776281265 @default.
- W4386909786 hasConceptScore W4386909786C2777752112 @default.
- W4386909786 hasConceptScore W4386909786C2777752497 @default.
- W4386909786 hasConceptScore W4386909786C2778305200 @default.
- W4386909786 hasConceptScore W4386909786C2778439535 @default.
- W4386909786 hasConceptScore W4386909786C2781338262 @default.
- W4386909786 hasConceptScore W4386909786C41091548 @default.
- W4386909786 hasConceptScore W4386909786C502942594 @default.
- W4386909786 hasConceptScore W4386909786C55493867 @default.
- W4386909786 hasConceptScore W4386909786C64927066 @default.
- W4386909786 hasConceptScore W4386909786C71240020 @default.
- W4386909786 hasConceptScore W4386909786C85240754 @default.
- W4386909786 hasConceptScore W4386909786C86803240 @default.
- W4386909786 hasConceptScore W4386909786C98274493 @default.
- W4386909786 hasFunder F4320320719 @default.
- W4386909786 hasLocation W43869097861 @default.
- W4386909786 hasLocation W43869097862 @default.
- W4386909786 hasOpenAccess W4386909786 @default.